Fig. 4

Immune cell-mediated clearance of senescent cells

a) Adoptive NK cell transfer combined with radio and chemotherapy. b) Approaches aimed at fostering NK cell recognition and killing of senescent cells including: (i) stabilization of NKG2DLs on senescent cell surface by blocking the protease-mediated cleavage through iMMPs or mAbs targeting the MICA/B shedding domain; (ii) targeting CD94/NKG2A inhibitory receptor using anti-NKG2A therapeutic mAb (i.e.: monalizumab); (iii) ADCC triggered by anti-DDP4 mAb. c) Enhancement of T cell mediated functions by targeting PD-1/PDL-1 axis; generation of uPAR specific CAR-T cells; d) depletion of senescent T lymphocytes following αCD153 vaccination

Abbreviations: iMMPs (metalloproteinase inhibitors); ADCC (Antibody dependent cellular cytotoxicity); NKG2DLs (NKG2D ligands)

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