Table 1 Targeting SASP regulators in experimental models of senescence

H-RAS ^V12

Human fibrobasts (IMR90)

HMGB2

Nd

shRNA

[184]

4-OHT/H-RAS^V12

Human fibrobasts (IMR90)

MLL1

M-2-2

shRNA

[185]

H-RAS ^V12

Human fibrobasts (IMR90;

WI-38)

BRD4

JQ1

shRNA

[42]

Pten^−/− mice

Prostate tumors

JAK2/STAT3

NVP-BSK805

Stat3^−/− mice

[187]

Ionizing radiation

Pre-adipocytes;

HUVEC

JAK1/2

Ruxolitinib

nd

[188]

Ionizing radiation

Human fibrobasts

(IMR90 and WI-38)

G3BP1

EGCG*

shRNA

[168]

4-OHT/ ER:RAS

Human fibrobasts (IMR90;

BJ;HFFF2)

mTORC1

Rapamycin

Torin1

NVP-BEZ235

shRNA

[190]

4-OHTor Etoposide/

H-RAS^V12;

pancreatic cancer mouse model

Human fibrobasts (IMR90)

IL1R/IL-1α

Nd

shRNA;

IL1R^−/− mice

[192]

4-OHT/ ER:RAS

Human fibrobasts (IMR90);MR90;MCF7

PTBP1

Nd

siRNA

[186]