rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC

Table 4 Association between C/C genotype in rs822336 and OS of NSCLC patients treated with anti-PD-1/PD-L1 therapy: multivariate analysis

Variables	HR	p-value	95% CI	Univariate p-value
rs822336^C/C vs. rs822336^{G/C or G/G}	0.5424147	0.010	0.3408916–0.8630712	0.0020
Current smoker vs. never/previous smoker	0.3902317	0.016	0.1809386–0.841616	0.0126
Age	0.9963466	0.860	0.9566538–1.037686	0.0008
ECOG PS 0 vs. 1/2	1.211215	0.325	0.8269563–1.774027	0.0430

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