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Fig. 4 | Molecular Cancer

Fig. 4

From: Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application

Fig. 4

Methods and prospects for inducing TLS in mice and cancer patients in vivo The emergence of TLS has been induced in the past in mice or cancer patients by means of cytokines and chemokines, chemotherapy, radiotherapy, cancer vaccines and immunotherapy. Recently lysosomal viruses (OV) have also raised possibilities in TLS induction. In addition to this, biomaterials show considerable promise for TLS induction. Collagen matrices, hydrogels, nanomaterials, three-dimensional (3D) scaffolds, and organoids all have the potential to serve as new induction modalities

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Molecular Cancer

ISSN: 1476-4598