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Fig. 2 | Molecular Cancer

Fig. 2

From: Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Fig. 2

The expression of p16 and p21 was significantly elevated after irinotecan-based chemotherapy in mCRC patients of cohort 2. (A) IHC staining of p16 and p21 in matched CRC tissues. pre-Treat, colonoscopy biopsies or surgically resected tumors before anti-cancer treatment. post-Treat, surgically resected tumors after irinotecan-based chemotherapy. (B) The staining distribution of p16 and p21. (C) The intensity score of p16 and p21. (D and E) The IRS of p16 and p21. (F) Kaplan-Meier plots of PFS. The plot was generated according to the difference between pre-Treat IRS and post-Treat IRS of p16 (p16-diff) and p21 (p21-diff). *p < 0.05, **p < 0.01, and ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598