Fig. 5

Overview of the major TCR signalling pathways. The major signalling components and transcription factors involved in the transduction of TCR signals are shown in the figure. The red, blue, grey boxes represent stimulatory, inhibitory, and transcription factors, respectively. AP-1, activator protein 1; BCL10, B-cell lymphoma/leukaemia 10; CARMA1, CARD-containing MAGUK protein 1; CRAC, calcium release activated channel; CUL5, cullin-5; DAG, diacylglycerol; DGKA, diacylglycerol kinase alpha; DGKZ, diacylglycerol kinase zeta; DUSP6, dual specificity phosphatase 6; ERK, extracellular signal-regulated kinase 1; FAM49B, family with sequence similarity 49 member B; Fyn, FYN proto-oncogene; GRB2, growth factor receptor-bound protein 2; LAT, linker for activation of T cells; MEKK1, mitogen-activated protein kinase kinase kinase 1; IP3, inositol-1,4,5-trisphosphate; ITK, IL2 inducible T cell kinase; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PLC-γ1, phospholipase C-gamma 1; PTPN6, protein tyrosine phosphatase non-receptor type 6; RNF7, ring finger protein 7; RHOH, Ras homolog family member H; SOCS1, suppressor of cytokine signalling 1; SLA2, Src like adaptor 2; TCEB2, elongin B; TCR, T cell receptor; UBASH3A, ubiquitin associated and SH3 domain containing A; VAV1, vav guanine nucleotide exchange factor 1; Zap70 ζ-chain associated protein kinase of 70 kDa