Fig. 4
From: tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Regulatory mechanism of tsRNAs in cancers. tsRNAs interact with proteins and genes to modulate important signaling cascades within tumor cells, including Notch (e.g., tRF/miR-1280) (A), Wnt (e.g., tRF3008A, tRF-19-PNR8YPJZ) (B), MAPK (e.g., tRF-Glu-TTC-027, tRF-Val-CAC-016) (C), PI3K/AKT (e.g., tRF-5026a) (D), NF-κB (e.g., tRF-3013b) (E), and MDM2/P53 (e.g., tRF-Val) signaling pathways (F)