Fig. 5
From: tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
tsRNAs regulate tumorigenesis. A tsRNAs (e.g., tsRNA-5001a and tRF-Val) promote tumor proliferation; tsRNAs (e.g., tRF-Glu49 and tRF-3013b) inhibit tumor proliferation. B tsRNAs (e.g., tRF-3017 A and 5’-tRF-GlyGCC) promote tumor metastasis; tsRNAs (e.g., tRF-20-M0NK5Y93 and tRF/miR-1280) suppress tumor metastasis. C tsRNAs (e.g., tRF29-R9J8909NF5JP) promote tumor angiogenesis; tsRNAs (e.g., tRiMetF31) inhibit tumor angiogenesis. D tsRNAs (e.g., 3P_tRNA-Thr-CGT-4-1 and 3P_tRNA-Arg-TCT-4-1) regulate the body’s immune response to NSCLC cells. E tsRNAs (e.g., tDR-0009, tDR-7336, tRF-315, and tRF-16-K8J7K1B) promote tumor resistance. F tsRNAs (e.g., tRFLys-CTT-010 and 5’tiRNA-Pro-TGG) promote the metabolic reprogramming of tumor cells