Fig. 6
From: tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Clinical application of tsRNAs as a cancer diagnostic biomarker and therapeutic target for tumors. (A-B) tsRNAs can be used as a novel biomarker for cancer diagnosis. tsRNAs are found in human tissues and various body fluids (e.g. plasma, serum, urine, cerebrospinal fluid, and saliva) (A); Dysregulation of tsRNAs is closely related to clinicopathological features (such as tumor progression and poor prognosis) (B). (C-E) tsRNAs also have potential as cancer therapeutic targets. In mouse xenotransplantation models, overexpression of tRF3008A inhibited the proliferation and metastasis of CRC cells by inhibiting the FOXK1/Wnt pathway (C); anti-leu3’tslna (knockdown 3’tRF-LeuCAG) reduces ribosomal biogenesis by down-regulating RPS28 mRNA translation, thereby inhibiting HCC cell proliferation (D); tRF-Glu-TTC-027 agomir (overexpressing tRF-Glu-TTC-027) inhibits GC cell proliferation by inhibiting the MAPK signaling pathway (E)