Table 3 Correlation between tsRNAs and clinicopathological features of cancers
From: tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Types of cancers | Samples | tsRNAs | Expression | Relationship with clinicopathologic features | AUC | Ref. |
|---|---|---|---|---|---|---|
Lung adenocarcinoma | Plasma | tRF-1:29-Pro-AGG-1-M6 | ↓ | TNM stage | 0.882 | [166] |
tRF-55:76-Tyr-GTA-1-M2 | ↑ | 0.896 | ||||
Non-small cell lung cancer | Exosome | tRF-Ala-AGC-036 | ↓ | TNM stage | 0.737 | [167] |
Colorectal cancer | Plasma | 5’-tRF-GlyGCC | ↑ | Clinical stage | 0.882 | [168] |
Pancreatic cancer | Serum | tRF-Pro-AGG-004 | ↑ | Survival | 0.900 | [169] |
tRF-Leu-CAG-002 | ↑ | 0.780 | ||||
Hepatocellular carcinoma | Serum | tRF-Gln-TTG-006 | ↑ | Clinical stage | 0.858 | [170] |
Gastric cancer | Serum | tRF-23-Q99P9P9NDD | ↑ | Lymphatic metastasis, TNM stage, neurological/vascular invasion, survival | 0.783 | [171] |
tRF-27-FDXXE6XRK45 | ↑ | TNM stage, lymphatic metastasis, neurological/vascular invasion | 0.805 | [172] | ||
Endometrial carcinoma | Exosome | tRF-20-S998LO9D | ↓ | - | 0.768 | [173] |