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Fig. 9 | Molecular Cancer

Fig. 9

From: Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer

Fig. 9

RBM15 and IGF2BPs significantly inhibited cell migration in prostate cancer. A-B Representative images of metastatic lesions at 10 weeks after the injection of indicated PC-3 cells into the tail vein of nude mice (A, n = 6 per group), and HE staining (B) of metastatic nodules of the lung and bone were shown (magnification, ×40, ×100, scale bar 100 μm). C-D Effect of wild-type or mutated IGF2BPs on restoring cell migration in IGF2BP-KO cells. Data shown represent mean value of 3 independent experiments (C: DU-145 cells, D: PC-3 cells). E Transwell migration assays showed the cell migration viabilities in RBM15 KO cells treated by IGF2BPs overexpression. F Transwell migration assays showed the inhibition of cell migration viabilities in RBM15 overexpression cells

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Molecular Cancer

ISSN: 1476-4598