Fig. 8
Combined HSP90A and TIP60 inhibition deters TNBC lung micro-metastases. (A) Exosomal LAP-TGF-β1 levels post 231 LuT3 cell treatment with specific inhibitors (n = 3). (B-D) After three weeks of intravenous injection of exosomes released from 231 LuT3 cells treated with 17-AAG and/or NU9056, mice were further intravenously injected with 5 × 105 GFP-Luc-labeled 231 LuT3 cells (n = 5). (B) Schematic representation of the TNBC lung metastasis model influenced by exosomes. (C) Depicts luminescent lung images alongside metastases quantification on days 5, 10, and 15 post cell injection. (D) By day 15 post-injection, GFP lung metastasis visual documentation and subsequent lesion quantifications. Scale bars: 10 mm and 1 mm. Data is mean ± SD