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Fig. 9 | Molecular Cancer

Fig. 9

From: The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis

Fig. 9

Schematic elucidation of LAP-TGF-β1 acetylation’s role in TNBC lung micro-metastases. LAP-TGF-β1 on exosomes from lung metastatic foci is acetylated at its K304 site via TIP60 mediation, leading to its interaction with HSP90A and facilitating its translocation from the Golgi apparatus to endosomes, resulting in the generation of exosomes with elevated LAP-TGF-β1 expression, reshaping the lung vascular niche, and ultimately promoting the dissemination of lung micro-metastases in TNBC

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Molecular Cancer

ISSN: 1476-4598