Fig. 4From: R-loop and diseases: the cell cycle mattersCell-cycle-dependent R-loop resolution factor. For the cell-cycle-dependent R-loop factor, the THO complex plays a role in both the G1 phase and the S phase. In addition, Sen1 and Primpol can also resolve it in the S phase. In the G2/M phase, RNase H2 is the principal factor that resolves the RNA portion of the RNA: DNA hybrid strand.Back to article page