Fig. 5

Cell-cycle-independent R-loop resolution factor. a Regardless of the cell cycle status, RNase H1 can reduce the accumulation of the R-loop by cutting the RNA portion of the hybrid, which is attributed to the constant high expression level of RNase H1 in the cell cycle. b UAP56/DDX39B is an effective helicase that prevents and/or eliminates the co-transcribed R-loop. Its role is to release new RNA from DNA, giving it the opportunity for further processing