R-loop and diseases: the cell cycle matters

Table 1 Factors regulating R-loop homeostasis

Type of factors	Factors	Function	Reference
Ribonucleases	RNase H1, RNase H2 [19]	resolution	[19]
Helicases	C1orf109L [18], UAP56/ DDX39B [54], FEN1 [67], DDX18 [71], SETX/Sen1 [72], DDX17 [73], DDX19 [74], DDX5 [75], DDX1 [76], DDX41 [77],DDX21 [78], AQR [79], BLM [80]	resolution	[18, 54, 67, 71,72,73,74,75,76,77,78,79,80]
Helicases	DHX9 [38]	formation	[38]
Topoisomerases	Top1 [56], TOP2A [81]	resolution	[56, 81]
DNA damage repair factors	MUS8 [12], BRCA1 [60], SAMHD1 [68], PrimPol [82], BRCA2 [83], MRE11 [84], Fanconi anemia factor, XPG, XPF, XAB2 [85], CtIP [86], APTX, TDP1 [87]	resolution	[12, 60, 68, 82,83,84,85,86,87]
DNA damage repair factors	RAD51 [88], RPA [89]	formation	[88, 89]
Transcription and RNA processing factors	Thrap3 [45], THO complex [62], TonEBP [65], SPT6 [90], WDR33 [91], XRN2 [92]	resolution	[45, 62, 65, 69, 90,91,92]
Transcription and RNA processing factors	CE (capping enzyme) [93]	formation	[93]
Chromosome remodeling factors	SIN3A [17], BRD4 [46], SWI/SNF [64], INO80 [94], SIRT7, PBRM1, ATRX [81], FACT [95], BRD2 [96]	resolution	[17, 46, 64, 81, 94,95,96]
RNA modification (Writers & Readers)	METTL3 [65], YTHDF2 [66], ADAR1 [69], TRDMT1 [81]	resolution	[65, 66, 69, 81]

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