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Molecular Cancer

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  1. Content type: Research

    Acquired drug resistance is one of the major reasons for failing cancer therapies. Although the reasons are not fully understood, they may be related to the presence of cancer stem cells (CSCs). We have report...

    Authors: Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana, Sindhu G. Rajendra, Edi Levi and Adhip PN Majumdar

    Citation: Molecular Cancer 2015 14:98

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  2. Content type: Research

    The EGFR signaling pathway is frequently activated in human ovarian cancer and associated with poor prognosis. However, inhibition of EGFR signaling in patients with recurrent ovarian cancer has been disappoin...

    Authors: Wei Wen, Jun Wu, Lucy Liu, Yan Tian, Ralf Buettner, Meng-Yin Hsieh, David Horne, Thanh H Dellinger, Ernest S Han, Richard Jove and John H Yim

    Citation: Molecular Cancer 2015 14:100

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  3. Content type: Research

    Homeobox genes encode transcription factors that control patterning of virtually all organ systems including the vasculature. Tumor angiogenesis is stimulated by several homeobox genes that are overexpressed i...

    Authors: Bon Trinh, Song Yi Ko, Dhwani Haria, Nicolas Barengo and Honami Naora

    Citation: Molecular Cancer 2015 14:97

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  4. Content type: Research

    Salivary Adenoid cystic carcinoma (SACC) patients with local invasion and lung metastasis are often resistant to conventional therapy such as operation, chemotherapy and radiotherapy. To explore the underling ...

    Authors: Lijuan Sun, Bodu Liu, Zhaoyu Lin, Yandan Yao, Yanyang Chen, Yang Li, Jianing Chen, Dongsheng Yu, Zhangui Tang, Bosheng Wang, Shuguang Zeng, Song Fan, Youyuan Wang, Yilin Li, Erwei Song and Jinsong Li

    Citation: Molecular Cancer 2015 14:96

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  5. Content type: Research

    Recent evidence suggests an important role of protein phosphatase 4 (PP4C) in the progression of several cancers, including breast cancer, lung cancer and pancreatic ductal adenocarcinoma. However, the contrib...

    Authors: Xinxiang Li, Lei Liang, Liyong Huang, Xiaoji Ma, Dawei Li and Sanjun Cai

    Citation: Molecular Cancer 2015 14:95

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  6. Content type: Research

    Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We re...

    Authors: David Westover, Xiang Ling, Hong Lam, Jacob Welch, Chunyang Jin, Celine Gongora, Maguy Del Rio, Mansukh Wani and Fengzhi Li

    Citation: Molecular Cancer 2015 14:92

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  7. Content type: Research

    Previous studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological limitations of micro...

    Authors: Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis…

    Citation: Molecular Cancer 2015 14:94

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    The Erratum to this article has been published in Molecular Cancer 2015 14:144

  8. Content type: Research

    Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels fol...

    Authors: Chencheng Xie, Huarui Lu, Alice Nomura, Eric Allan Hanse, Colleen Lynn Forster, Josh Berken Parker, Michael Andrew Linden, Chris Karasch and Timothy Curtis Hallstrom

    Citation: Molecular Cancer 2015 14:93

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  9. Content type: Research

    KLF5 is a basic transcriptional factor that regulates multiple physiopathological processes. Our recent study showed that deletion of Klf5 in mouse prostate promotes tumorigenesis initiated by the deletion of Pte...

    Authors: Xinpei Ci, Changsheng Xing, Baotong Zhang, Zhiqian Zhang, Jenny Jianping Ni, Wei Zhou and Jin-Tang Dong

    Citation: Molecular Cancer 2015 14:91

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  10. Content type: Research

    Accumulating evidence suggests that some long noncoding RNAs (lncRNAs) are involved in certain diseases, such as cancer. The lncRNA, CCDC26, is related to childhood acute myeloid leukemia (AML) because its copy n...

    Authors: Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida and Takeshi Yamazaki

    Citation: Molecular Cancer 2015 14:90

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  11. Content type: Letter to the Editor

    In chronic myeloid leukemia, the identification of individual BCR-ABL1 fusions is required for the development of personalized medicine approach for minimal residual disease monitoring at the DNA level. Next gene...

    Authors: Jana Linhartova, Lenka Hovorkova, Simona Soverini, Adela Benesova, Monika Jaruskova, Hana Klamova, Jan Zuna and Katerina Machova Polakova

    Citation: Molecular Cancer 2015 14:89

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  12. Content type: Erratum

    Authors: Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Zhiqun Shang, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu and Amilcar Flores-Morales

    Citation: Molecular Cancer 2015 14:88

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    The original article was published in Molecular Cancer 2015 14:8

  13. Content type: Review

    Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of ca...

    Authors: Lifang Zhang, Jianhong Wu, Ming Tat Ling, Liang Zhao and Kong-Nan Zhao

    Citation: Molecular Cancer 2015 14:87

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  14. Content type: Research

    Neuropilin 2 (NRP2) isa multi-functional co-receptor to many receptors, including VEGF receptor, c-Met and others. NRP2 has recently been implicated in tumor angiogenesis, growth, and metastasis of many other ...

    Authors: Tao Ji, Yi Guo, Kapjun Kim, Peter McQueen, Samia Ghaffar, Alexander Christ, Carol Lin, Ramez Eskander, Xiaolin Zi and Bang H Hoang

    Citation: Molecular Cancer 2015 14:86

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  15. Content type: Research

    Chemoresistance is a major obstacle in successfully treating cancers, and the mechanisms responsible for drug resistance are still far from understood. Carbonic anhydrase 9 (CA9) has been shown to be upregulat...

    Authors: Guopei Zheng, Cong Peng, Xiaoting Jia, Yixue Gu, Zhijie Zhang, Yingen Deng, Chengkun Wang, Nan Li, Jiang Yin, Xiaorong Liu, Minying Lu, Hailin Tang and Zhimin He

    Citation: Molecular Cancer 2015 14:84

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  16. Content type: Research

    Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development...

    Authors: Anthony J Apostoli, Jennifer M Roche, Mark M Schneider, Sandip K SenGupta, Michael A Di Lena, Rachel E Rubino, Nichole T Peterson and Christopher JB Nicol

    Citation: Molecular Cancer 2015 14:85

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  17. Content type: Research

    Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the overall biological role and clinical significance of PVT1 in gastric carcinogenesis remains...

    Authors: Rong Kong, Er-bao Zhang, Dan-dan Yin, Liang-hui You, Tong-peng Xu, Wen-ming Chen, Rui Xia, Li Wan, Ming Sun, Zhao-xia Wang, Wei De and Zhi-hong Zhang

    Citation: Molecular Cancer 2015 14:82

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  18. Content type: Research

    Head and neck cancer (HNC) is a highly invasive cancer. Aurora-A has been reported for a number of malignancies. However, the identity of downstream effectors responsible for its aggressive phenotype in HNC re...

    Authors: Chang-Han Chen, Alice YW Chang, Shau-Hsuan Li, Hsin-Ting Tsai, Li-Yen Shiu, Li-Jen Su, Wen-Lung Wang, Tai-Jen Chiu, Sheng-Dean Luo, Tai-Lin Huang and Chih-Yen Chien

    Citation: Molecular Cancer 2015 14:83

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  19. Content type: Research

    In colorectal carcinoma (CRC), activation of the Raf/MEK/ERK signaling pathway is commonly observed. In addition, the commonly used 5FU-based chemotherapy in patients with metastatic CRC was found to enrich a ...

    Authors: Ariel KM Chow, Nathan SM Cheng, Colin SC Lam, Lui Ng, Sunny KM Wong, Timothy MH Wan, Johnny HW Man, Alvin HK Cheung, Thomas CC Yau, Jensen TC Poon, Wai-Lun Law and Roberta WC Pang

    Citation: Molecular Cancer 2015 14:80

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  20. Content type: Short communication

    RUNX1/AML1, which is a Runt family transcription factor critical for normal hematopoiesis, is frequently mutated or translocated in a broad spectrum of hematopoietic malignancies.

    Authors: Hong Yao, Jinlan Pan, Chunxiao Wu, Hongjie Shen, Jundan Xie, Qinrong Wang, Lijun Wen, Qian Wang, Liang Ma, Lili Wu, Nana Ping, Yun Zhao, Aining Sun and Suning Chen

    Citation: Molecular Cancer 2015 14:81

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  21. Content type: Research

    High toxicity, morbidity and secondary malignancy render chemotherapy of neuroblastoma inefficient, prompting the search for novel compounds. Nanovesicles offer great promise in imaging and treatment of cancer...

    Authors: Mahaboob K Sulaiman, Zhengtao Chu, Victor M Blanco, Subrahmanya D Vallabhapurapu, Robert S Franco and Xiaoyang Qi

    Citation: Molecular Cancer 2015 14:78

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  22. Content type: Research

    Tumor hypoxia is one of the features of tumor microenvironment that contributes to chemoresistance. miRNAs have recently been shown to play important roles in tumorigenesis and drug resistance. Moreover, hypox...

    Authors: Magali Rebucci, Audrey Sermeus, Elodie Leonard, Edouard Delaive, Marc Dieu, Maude Fransolet, Thierry Arnould and Carine Michiels

    Citation: Molecular Cancer 2015 14:79

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  23. Content type: Research

    Elucidation of the molecular mechanisms by which cancer cells overcome hypoxia is potentially important for targeted therapy. Complexation of hypoxia-inducible factors (HIFs) with aryl hydrocarbon receptor nuc...

    Authors: Shiro Koizume, Shin Ito, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Mitsuko Furuya, Roppei Yamada, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano and Yohei Miyagi

    Citation: Molecular Cancer 2015 14:77

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  24. Content type: Review

    p66Shc, a member of the ShcA (Src homologous- collagen homologue) adaptor protein family, is one of the three isoforms of this family along with p46Shc and p52Shc. p66Shc, a 66 kDa protein is different from th...

    Authors: Sahar S Bhat, Deepak Anand and Firdous A Khanday

    Citation: Molecular Cancer 2015 14:76

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