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  1. Content type: Research

    MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types.

    Authors: Paola Parrella, Raffaela Barbano, Barbara Pasculli, Andrea Fontana, Massimiliano Copetti, Vanna Maria Valori, Maria Luana Poeta, Giuseppe Perrone, Daniela Righi, Marina Castelvetere, Michelina Coco, Teresa Balsamo, Maria Morritti, Fabio Pellegrini, Andrea Onetti-Muda, Evaristo Maiello…

    Citation: Molecular Cancer 2014 13:142

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  2. Content type: Short communication

    Inhibition of the activated epidermal growth factor receptor (EGFR) with either enzymatic kinase inhibitors or anti-EGFR antibodies such as cetuximab, is an effective modality of treatment for multiple human c...

    Authors: Jeonghee Cho, Adam J Bass, Michael S Lawrence, Kristian Cibulskis, Ahye Cho, Shi-Nai Lee, Mai Yamauchi, Nikhil Wagle, Panisa Pochanard, Nayoung Kim, Angela K J Park, Jonghwa Won, Hyung-Suk Hur, Heidi Greulich, Shuji Ogino, Carrie Sougnez…

    Citation: Molecular Cancer 2014 13:141

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  3. Content type: Erratum

    Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Masaya Miyazaki, Makiko Kitagawa, Mohamed Kamel Hassan, Peixin Dong, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi

    Citation: Molecular Cancer 2014 13:140

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    The original article was published in Molecular Cancer 2014 13:97

  4. Content type: Research

    The introduction of cisplatin has improved the long-term survival rate in osteosarcoma patients. However, some patients are intrinsically resistant to cisplatin. This study reported that the activation of Notc...

    Authors: Lei Wang, Fangchun Jin, An Qin, Yongqiang Hao, Yufeng Dong, Shengfang Ge and Kerong Dai

    Citation: Molecular Cancer 2014 13:139

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  5. Content type: Research

    Although long-term estrogen (E2) exposure is associated with increased breast cancer (BC) risk, and E2 appears to sustain growth of BC cells that express functional estrogen receptors (ERs), its role in promot...

    Authors: Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang, Guangwei Wei and Junmin Wei

    Citation: Molecular Cancer 2014 13:137

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  6. Content type: Research

    Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many epithelial tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally,...

    Authors: Heming Li, Ling Xu, Ce Li, Lei Zhao, Yanju Ma, Huachuan Zheng, Zhi Li, Ye Zhang, Ruoyu Wang, Yunpeng Liu and Xiujuan Qu

    Citation: Molecular Cancer 2014 13:136

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  7. Content type: Research

    Interferon (IFN)-γ-mediated immune response plays an important role in tumor immunosurveillance. However, the regulation of IFN-γ-mediated tumorigenesis and immune response remains elusive. USP18, an interfero...

    Authors: Bangxing Hong, Haiyan Li, Yong Lu, Mingjun Zhang, Yuhuan Zheng, Jianfei Qian and Qing Yi

    Citation: Molecular Cancer 2014 13:132

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  8. Content type: Research

    KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to an...

    Authors: Yu Imamura, Paul Lochhead, Mai Yamauchi, Aya Kuchiba, Zhi Rong Qian, Xiaoyun Liao, Reiko Nishihara, Seungyoun Jung, Kana Wu, Katsuhiko Nosho, Yaoyu E Wang, Shouyong Peng, Adam J Bass, Kevin M Haigis, Jeffrey A Meyerhardt, Andrew T Chan…

    Citation: Molecular Cancer 2014 13:135

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  9. Content type: Research

    Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide...

    Authors: Tongsen Zheng, Dalong Yin, Zhaoyang Lu, Jiabei Wang, Yuejin Li, Xi Chen, Yingjian Liang, Xuan Song, Shuyi Qi, Boshi Sun, Changming Xie, Xianzhi Meng, Shangha Pan, Jiaren Liu, Hongchi Jiang and Lianxin Liu

    Citation: Molecular Cancer 2014 13:133

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  10. Content type: Research

    The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we repo...

    Authors: Naoomi Tominaga, Keitaro Hagiwara, Nobuyoshi Kosaka, Kimi Honma, Hitoshi Nakagama and Takahiro Ochiya

    Citation: Molecular Cancer 2014 13:134

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  11. Content type: Research

    Increasing evidence indicates an important role of transcription factor Yin Yang-1 (YY1) in human tumorigenesis. However, its function in cancer remains controversial and the relevance of YY1 to pancreatic duc...

    Authors: Jing-Jing Zhang, Yi Zhu, Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang, Zheng Li, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du and Yi Miao

    Citation: Molecular Cancer 2014 13:130

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  12. Content type: Review

    Over three decades have passed since the first report on the expression of CA125 by ovarian tumors. Since that time our understanding of ovarian cancer biology has changed significantly to the point that these...

    Authors: Mildred Felder, Arvinder Kapur, Jesus Gonzalez-Bosquet, Sachi Horibata, Joseph Heintz, Ralph Albrecht, Lucas Fass, Justanjyot Kaur, Kevin Hu, Hadi Shojaei, Rebecca J Whelan and Manish S Patankar

    Citation: Molecular Cancer 2014 13:129

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  13. Content type: Research

    Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains e...

    Authors: Xin Tang, Theresa B Kuhlenschmidt, Qian Li, Shahjahan Ali, Stephane Lezmi, Hong Chen, Melissa Pires-Alves, William W Laegreid, Taher A Saif and Mark S Kuhlenschmidt

    Citation: Molecular Cancer 2014 13:131

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  14. Content type: Research

    Hepatitis B virus X protein (HBx) plays crucial roles in hepatocarcinogenesis. However, the underlying mechanism remains elusive. We have reported that HBx is able to up-regulate survivin in hepatocellular car...

    Authors: Weiying Zhang, Zhanping Lu, Guangyao Kong, Yuen Gao, Tao Wang, Qi Wang, Na Cai, Honghui Wang, Fabao Liu, Lihong Ye and Xiaodong Zhang

    Citation: Molecular Cancer 2014 13:128

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  15. Content type: Research

    microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence sugge...

    Authors: Yantao Duan, Lei Hu, Bing Liu, Beiqin Yu, Jianfang Li, Min Yan, Yingyan Yu, Chen Li, Liping Su, Zhenggang Zhu, Ming Xiang, Bingya Liu and Qiumeng Yang

    Citation: Molecular Cancer 2014 13:127

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  16. Content type: Research

    Transforming growth factor, beta (TGFB) signal is considered to be a tumor suppressive pathway based on the frequent genomic deletion of the SMAD4 gene in pancreatic cancer (PC); however; the role of the activin ...

    Authors: Yosuke Togashi, Hiroki Sakamoto, Hidetoshi Hayashi, Masato Terashima, Marco A de Velasco, Yoshihiko Fujita, Yasuo Kodera, Kazuko Sakai, Shuta Tomida, Masayuki Kitano, Akihiko Ito, Masatoshi Kudo and Kazuto Nishio

    Citation: Molecular Cancer 2014 13:126

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  17. Content type: Research

    Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity in the aging male population and represents the most frequently diagnosed malignancy in men around the world. The De...

    Authors: Samia B Bachmann, Sandra C Frommel, Rosalba Camicia, Hans C Winkler, Raffaella Santoro and Paul O Hassa

    Citation: Molecular Cancer 2014 13:125

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  18. Content type: Research

    miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer...

    Authors: Lijing Zhang, Yujuan Dong, Nana Zhu, Ho Tsoi, Zengren Zhao, Chung Wah Wu, Kunning Wang, Shu Zheng, Simon SM Ng, Francis KL Chan, Joseph JY Sung and Jun Yu

    Citation: Molecular Cancer 2014 13:124

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  19. Content type: Research

    Colorectal cancers carrying the B-Raf V600E-mutation are associated with a poor prognosis. The purpose of this study was to identify B-RafV600E-mediated traits of cancer cells in a genetic in vitro model and to a...

    Authors: Benjamin Hirschi, Eike Gallmeier, Andreas Ziesch, Maximilian Marschall and Frank T Kolligs

    Citation: Molecular Cancer 2014 13:122

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  20. Content type: Research

    Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patie...

    Authors: Leah Morenos, Zac Chatterton, Jane L Ng, Minhee S Halemba, Mandy Parkinson-Bates, Francoise Mechinaud, Ngaire Elwood, Richard Saffery and Nicholas C Wong

    Citation: Molecular Cancer 2014 13:123

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  21. Content type: Research

    Epithelial-to-mesenchymal transition (EMT) is a key step of the progression of tumor cell metastasis. Recent work has demonstrated some miRNAs play critical roles in EMT. In this study, we focused on the roles...

    Authors: Jingshuang Yu, Furong Xie, Xin Bao, Wantao Chen and Qin Xu

    Citation: Molecular Cancer 2014 13:121

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  22. Content type: Research

    Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon ar...

    Authors: Kelong Ma, Xiaorong Pan, Pingsheng Fan, Yinghua He, Jun Gu, Wei Wang, Tengyue Zhang, Zonghai Li and Xiaoying Luo

    Citation: Molecular Cancer 2014 13:118

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  23. Content type: Research

    Insertional mutagenesis screens have been used with great success to identify oncogenes and tumor suppressor genes. Typically, these screens use gammaretroviruses (γRV) or transposons as insertional mutagens. ...

    Authors: Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows and Grant D Trobridge

    Citation: Molecular Cancer 2014 13:120

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  24. Content type: Research

    Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long non-coding RNAs (lncRNA) are a class of RNAs more than 200 nucleotides long that do not code for protein and are p...

    Authors: Arun Renganathan, Jelena Kresoja-Rakic, Nohemy Echeverry, Gabriela Ziltener, Bart Vrugt, Isabelle Opitz, Rolf A Stahel and Emanuela Felley-Bosco

    Citation: Molecular Cancer 2014 13:119

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  25. Content type: Short communication

    Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of Sfrp1 expression is observed in breast cancer. The molecular mechanisms by which obesity con...

    Authors: Kelly J Gauger, Lotfi M Bassa, Elizabeth M Henchey, Josephine Wyman, Jennifer Ser-Dolansky, Akihiko Shimono and Sallie S Schneider

    Citation: Molecular Cancer 2014 13:117

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  26. Content type: Research

    The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have pr...

    Authors: Ingvild Haaland, Jill A Opsahl, Frode S Berven, Håkon Reikvam, Hanne K Fredly, Ragnhild Haugse, Bernd Thiede, Emmet McCormack, Sonia Lain, Øystein Bruserud and Bjørn Tore Gjertsen

    Citation: Molecular Cancer 2014 13:116

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  27. Content type: Research

    We investigated whether combinations of serum cytokines, used with logistic disease predictor models, could facilitate the detection of pancreatic ductal adenocarcinoma (PDAC).

    Authors: Victoria E Shaw, Brian Lane, Claire Jenkinson, Trevor Cox, William Greenhalf, Christopher M Halloran, Joseph Tang, Robert Sutton, John P Neoptolemos and Eithne Costello

    Citation: Molecular Cancer 2014 13:114

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  28. Content type: Research

    Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emerg...

    Authors: Zuzana Pernicová, Eva Slabáková, Radek Fedr, Šárka Šimečková, Josef Jaroš, Tereza Suchánková, Jan Bouchal, Gvantsa Kharaishvili, Milan Král, Alois Kozubík and Karel Souček

    Citation: Molecular Cancer 2014 13:113

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  29. Content type: Research

    Transforming Growth Factor beta (TGF-β) acts as a tumor suppressor early in carcinogenesis but turns into tumor promoter in later disease stages. In fact, TGF-β is a known inducer of integrin expression by tum...

    Authors: Elizabeth Salvo, Saray Garasa, Javier Dotor, Xabier Morales, Rafael Peláez, Peter Altevogt and Ana Rouzaut

    Citation: Molecular Cancer 2014 13:112

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  30. Content type: Research

    Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that acts as a prognostic marker for several human malignancies. In this study, we investigated the clinical significance of CIP2A and it...

    Authors: Na Liu, Qing-Mei He, Jie-Wei Chen, Ying-Qin Li, Ya-Fei Xu, Xian-Yue Ren, Ying Sun, Hai-Qiang Mai, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng and Jun Ma

    Citation: Molecular Cancer 2014 13:111

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  31. Content type: Research

    The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 an...

    Authors: Kangsheng Tu, Wei Yang, Chao Li, Xin Zheng, Zhongtang Lu, Cheng Guo, Yingmin Yao and Qingguang Liu

    Citation: Molecular Cancer 2014 13:110

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  32. Content type: Research

    Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still ...

    Authors: Xin Xu, Jian Wu, Shiqi Li, Zhenghui Hu, Xianglai Xu, Yi Zhu, Zhen Liang, Xiao Wang, Yiwei Lin, Yeqing Mao, Hong Chen, Jindan Luo, Ben Liu, Xiangyi Zheng and Liping Xie

    Citation: Molecular Cancer 2014 13:109

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  33. Content type: Research

    DUSP3 phosphatase, also known as V accinia-H 1 R elated (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP...

    Authors: Mathieu Amand, Charlotte Erpicum, Khalid Bajou, Fabio Cerignoli, Silvia Blacher, Maud Martin, Franck Dequiedt, Pierre Drion, Pratibha Singh, Tinatin Zurashvili, Maud Vandereyken, Lucia Musumeci, Tomas Mustelin, Michel Moutschen, Christine Gilles, Agnes Noel…

    Citation: Molecular Cancer 2014 13:108

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  34. Content type: Research

    Survivin, a member of the inhibitor of apoptosis (IAP) gene family, has a dual role in mitosis and in apoptosis. It is abundantly expressed in every human tumor, compared with normal tissues. During mitosis Su...

    Authors: Ralf Wiedemuth, Barbara Klink, Katrin Töpfer, Evelin Schröck, Gabriele Schackert, Masaaki Tatsuka and Achim Temme

    Citation: Molecular Cancer 2014 13:107

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  35. Content type: Research

    Acylglycerol kinase (AGK) is reported to be overexpressed in multiple cancers. The clinical significance and biological role of AGK in breast cancer, however, remain to be established.

    Authors: Xi Wang, Chuyong Lin, Xiaohui Zhao, Aibin Liu, Jinrong Zhu, Xinghua Li and Libing Song

    Citation: Molecular Cancer 2014 13:106

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  36. Content type: Research

    Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (sno...

    Authors: Kaiissar Mannoor, Jun Shen, Jipei Liao, Zhenqiu Liu and Feng Jiang

    Citation: Molecular Cancer 2014 13:104

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  37. Content type: Research

    Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in vivo studies have demonstrated the therapeutic effects of inhibiti...

    Authors: Nathaniel Weygant, Dongfeng Qu, William L Berry, Randal May, Parthasarathy Chandrakesan, Daniel B Owen, Sripathi M Sureban, Naushad Ali, Ralf Janknecht and Courtney W Houchen

    Citation: Molecular Cancer 2014 13:103

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  38. Content type: Research

    Over 90% of cancer-related deaths in clear cell renal cell carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy o...

    Authors: Hala Girgis, Olena Masui, Nicole MA White, Andreas Scorilas, Fabio Rotondo, Annetta Seivwright, Manal Gabril, Emily R Filter, Andrew HA Girgis, Georg A Bjarnason, Michael AS Jewett, Andrew Evans, Sahar Al-Haddad, KW Michael Siu and George M Yousef

    Citation: Molecular Cancer 2014 13:101

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  39. Content type: Research

    Homeobox B9 (HOXB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as one of important transcriptional factors related to angiogenesis. This...

    Authors: Yoshinori Hoshino, Tetsu Hayashida, Akira Hirata, Hidena Takahashi, Naokazu Chiba, Mitsuyo Ohmura, Masatoshi Wakui, Hiromitsu Jinno, Hirotoshi Hasegawa, Shyamala Maheswaran, Makoto Suematsu and Yuko Kitagawa

    Citation: Molecular Cancer 2014 13:102

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  40. Content type: Research

    Vasohibin-2 (VASH2) has been identified as an endogenous and vascular endothelial growth factor (VEGF)-independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to d...

    Authors: Shuji Kitahara, Yasuhiro Suzuki, Masae Morishima, Asuka Yoshii, Sachiko Kikuta, Kazuhiko Shimizu, Shunichi Morikawa, Yasufumi Sato and Taichi Ezaki

    Citation: Molecular Cancer 2014 13:99

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  41. Content type: Research

    Elevated MELK expression is featured in multiple tumors and correlated with tumorigenesis and tumor development. This study is aimed to investigate the mechanisms of MELK-mediated development of gastric cancer.

    Authors: Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu and Bingya Liu

    Citation: Molecular Cancer 2014 13:100

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  42. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the an...

    Authors: Bin Wang, Zhenhong Ni, Xufang Dai, Liyan Qin, Xinzhe Li, Liang Xu, Jiqin Lian and Fengtian He

    Citation: Molecular Cancer 2014 13:98

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  43. Content type: Research

    We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with the malignant phenotype.

    Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, Mohamed Kamel Hassan, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi

    Citation: Molecular Cancer 2014 13:97

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    The Erratum to this article has been published in Molecular Cancer 2014 13:140

  44. Content type: Research

    Grb2 (Growth factor receptor-bound protein 2) is a key adaptor protein in maintaining the ERK activity via linking Sos1 (Son of sevenless homolog 1) or other proteins to activated RTKs, such as EGFR. Currently, l...

    Authors: Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu and Jian Huang

    Citation: Molecular Cancer 2014 13:95

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  45. Content type: Research

    Ras guanine nucleotide exchange factors (RasGEFs) mediate the activation of the Ras signaling pathway that is over activated in many human cancers. The RasGRP3, an activator of H-Ras and R-Ras protein exerts o...

    Authors: Zsuzsanna Nagy, Ilona Kovács, Miklós Török, Dezső Tóth, György Vereb, Krisztina Buzás, István Juhász, Peter M Blumberg, Tamás Bíró and Gabriella Czifra

    Citation: Molecular Cancer 2014 13:96

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  46. Content type: Research

    It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipula...

    Authors: Yan Wang, Ziliang Wang, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang, Zhen Zhang and Gong Yang

    Citation: Molecular Cancer 2014 13:94

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  47. Content type: Research

    Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of HOTAIR in gastr...

    Authors: Xiang-hua Liu, Ming Sun, Feng-qi Nie, Ying-bin Ge, Er-bao Zhang, Dan-dan Yin, Rong Kong, Rui Xia, Kai-hua Lu, Jin-hai Li, Wei De, Ke-ming Wang and Zhao-xia Wang

    Citation: Molecular Cancer 2014 13:92

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