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Molecular Cancer


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  1. Content type: Research

    The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is appar...

    Authors: Tien-Jen Lin, Hsin-Ting Lin, Wei-Ting Chang, Pradeep Mitapalli. S, Pei-Wen Hsiao, Shu-Yi Yin and Ning-Sun Yang

    Citation: Molecular Cancer 2015 14:174

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  2. Content type: Research

    Molecular iodine (I2) exhibits antiproliferative and apoptotic effects on in vivo and in vitro cancer models. These effects are thought to be mediated by an iodinated arachidonic acid derivative, 6-iodolactone (6...

    Authors: Mario Nava-Villalba, Rosa E. Nuñez-Anita, Alexander Bontempo and Carmen Aceves

    Citation: Molecular Cancer 2015 14:168

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  3. Content type: Research

    Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and its role in pathogenesis of HCC remain largely unknown.

    Authors: Qi-fei Tao, Sheng-xian Yuan, Fu Yang, Sen Yang, Yuan Yang, Ji-hang Yuan, Zhen-guang Wang, Qing-guo Xu, Kong-ying Lin, Jie Cai, Jian Yu, Wei-long Huang, Xiao-lei Teng, Chuan-chuan Zhou, Fang Wang, Shu-han Sun…

    Citation: Molecular Cancer 2015 14:170

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  4. Content type: Research

    The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain uncl...

    Authors: Helen B. Pearson, Edwina McGlinn, Toby J. Phesse, Holger Schlüter, Anuratha Srikumar, Nathan J. Gödde, Christina B. Woelwer, Andrew Ryan, Wayne A. Phillips, Matthias Ernst, Pritinder Kaur and Patrick Humbert

    Citation: Molecular Cancer 2015 14:169

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  5. Content type: Research

    Genetic alterations in tricarboxylic acid (TCA) cycle metabolic enzymes were recently linked to various cancers. However, the associations of single nucleotide polymorphisms (SNPs) in genes of these enzymes ha...

    Authors: Guanglong Dong, Xianli He, Yibing Chen, Haiyan Cao, Jiaojiao Wang, Xiaonan Liu, Shukui Wang, Shaogui Wan and Jinliang Xing

    Citation: Molecular Cancer 2015 14:171

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  6. Content type: Research

    The SWI/SNF ATP dependent chromatin remodeling complex is a multi-subunit complex, conserved in eukaryotic evolution that facilitates nucleosomal re-positioning relative to the DNA sequence. In recent years th...

    Authors: Jonatan Darr, Agnes Klochendler, Sara Isaac, Tami Geiger and Amir Eden

    Citation: Molecular Cancer 2015 14:167

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    The Erratum to this article has been published in Molecular Cancer 2016 15:14

  7. Content type: Research

    Although a relatively small proportion of all breast cancer (BC), triple negative (TN) BC is responsible for a relatively large proportion of BC deaths because of its worse clinical outcome. To investigate whe...

    Authors: Sei Sai, Guillaume Vares, Eun Ho Kim, Kumiko Karasawa, Bing Wang, Mitsuru Nenoi, Yoshiya Horimoto and Mitsuhiro Hayashi

    Citation: Molecular Cancer 2015 14:166

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  8. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lnc...

    Authors: Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu, Pei Ma and Yong-qian Shu

    Citation: Molecular Cancer 2015 14:165

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  9. Content type: Research

    Previous studies have established that levels of the Inhibitor of Growth 1(ING1) tumor suppressor are reduced in a significant proportion of different cancer types. Here we analyzed levels of ING1 in breast ca...

    Authors: Satbir Thakur, Arash Nabbi, Alexander Klimowicz and Karl Riabowol

    Citation: Molecular Cancer 2015 14:164

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  10. Content type: Research

    microRNA-122 (miR-122) is the most abundant and specific miRNA in the liver. It acts as an important tumor suppressor in hepatocellular carcinoma (HCC) through regulating its target genes, but details of its o...

    Authors: Jialin He, Kai Zhao, Lu Zheng, Zhizhen Xu, Wei Gong, Shan Chen, Xiaodong Shen, Gang Huang, Min Gao, Yijun Zeng, Yan Zhang and Fengtian He

    Citation: Molecular Cancer 2015 14:163

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  11. Content type: Research

    Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, ...

    Authors: Moitri Basu, Rahul Bhattacharya, Upasana Ray, Satinath Mukhopadhyay, Uttara Chatterjee and Sib Sankar Roy

    Citation: Molecular Cancer 2015 14:162

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  12. Content type: Research

    Glioblastoma (GBM) is the most common primary brain malignancy and confers a dismal prognosis. GBMs harbor glioblastoma-initiating cells (GICs) that drive tumorigenesis and contribute to therapeutic resistance...

    Authors: Awais A. Mughal, Zanina Grieg, Håvard Skjellegrind, Artem Fayzullin, Mustapha Lamkhannat, Mrinal Joel, M. Shakil Ahmed, Wayne Murrell, Einar O. Vik-Mo, Iver A. Langmoen and Biljana Stangeland

    Citation: Molecular Cancer 2015 14:160

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  13. Content type: Research

    The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a co...

    Authors: Seung Joon Lee, Alisa Litan, Zhiqin Li, Bruce Graves, Stephan Lindsey, Sonali P. Barwe and Sigrid A. Langhans

    Citation: Molecular Cancer 2015 14:159

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  14. Content type: Research

    Migration and invasion enhancer 1 (MIEN1) is a novel gene found to be abundantly expressed in breast tumor tissues and functions as a critical regulator of tumor cell migration and invasion to promote systemic...

    Authors: Marilyne Kpetemey, Subhamoy Dasgupta, Smrithi Rajendiran, Susobhan Das, Lee D. Gibbs, Praveenkumar Shetty, Zygmunt Gryczynski and Jamboor K. Vishwanatha

    Citation: Molecular Cancer 2015 14:156

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  15. Content type: Research

    CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells...

    Authors: Alice Conigliaro, Viviana Costa, Alessia Lo Dico, Laura Saieva, Simona Buccheri, Francesco Dieli, Mauro Manno, Samuele Raccosta, Carmine Mancone, Marco Tripodi, Giacomo De Leo and Riccardo Alessandro

    Citation: Molecular Cancer 2015 14:155

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  16. Content type: Research

    Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particul...

    Authors: TB Rounge, K Furu, RI Skotheim, TB Haugen, T Grotmol and E Enerly

    Citation: Molecular Cancer 2015 14:153

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  17. Content type: Research

    High grade epithelial ovarian cancer (EOC) is commonly characterised by widespread peritoneal dissemination and ascites. Metastatic EOC tumour cells can attach directly to neighbouring organs or alternatively,...

    Authors: Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay and Nuzhat Ahmed

    Citation: Molecular Cancer 2015 14:152

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  18. Content type: Research

    Synovial sarcoma account for approximately 10 % of all soft-tissue tumors and occur most frequently in young adults. A specific translocation in this sarcoma induces fusion of the SYT gene on chromosome 18 to ...

    Authors: Alba Fricke, Prisca V. Ullrich, Jürgen Heinz, Dietmar Pfeifer, Jutta Scholber, Georg W. Herget, Oliver Hauschild, Peter Bronsert, G. Björn Stark, Holger Bannasch, Steffen U. Eisenhardt and David Braig

    Citation: Molecular Cancer 2015 14:151

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  19. Content type: Research

    The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 expression in this group of patients is still ...

    Authors: Abdullah Alsuliman, Dilek Colak, Olfat Al-Harazi, Hanaa Fitwi, Asma Tulbah, Taher Al-Tweigeri, Monther Al-Alwan and Hazem Ghebeh

    Citation: Molecular Cancer 2015 14:149

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