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  1. Aberrant expression of microRNAs, small non-coding RNA molecules that post-transcriptionally repress gene expression, seems to be causatively linked to the pathogenesis of cancer. In this context, miR-21 was f...

    Authors: Marco Folini, Paolo Gandellini, Nicole Longoni, Valentina Profumo, Maurizio Callari, Marzia Pennati, Maurizio Colecchia, Rosanna Supino, Silvia Veneroni, Roberto Salvioni, Riccardo Valdagni, Maria Grazia Daidone and Nadia Zaffaroni
    Citation: Molecular Cancer 2010 9:12
    Content type: Research Published on:

  2. Cancer cells utilize a variety of mechanisms to evade immune detection and attack. Effective immune detection largely relies on the formation of an immune synapse which requires close contact between immune ce...

    Authors: Jennifer AA Gubbels, Mildred Felder, Sachi Horibata, Jennifer A Belisle, Arvinder Kapur, Helen Holden, Sarah Petrie, Martine Migneault, Claudine Rancourt, Joseph P Connor and Manish S Patankar
    Citation: Molecular Cancer 2010 9:11
    Content type: Research Published on:

  3. Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is...

    Authors: Li Xiao, Liu Yan, Wen Zhongmei, Li Chang, Lu Huijun, Tian Mingyao, Jin Kuoshi, Sun Lili, Gao Pegn, Yang Encheng, Xu Xiaohong, Kan Shifu, Wang Zhuoyue, Wang Yuhang and Jin Ningyi
    Citation: Molecular Cancer 2010 9:10
    Content type: Research Published on:

  4. Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family, which inhibits cell apoptosis by sequestering pro-apoptotic proteins Bim and Bid. Mcl-1 overexpression has been associated with progression in l...

    Authors: Shumin Zhang, Haiyen E Zhau, Adeboye O Osunkoya, Shareen Iqbal, Xiaojian Yang, Songqing Fan, Zhengjia Chen, Ruoxiang Wang, Fray F Marshall, Leland WK Chung and Daqing Wu
    Citation: Molecular Cancer 2010 9:9
    Content type: Research Published on:

  5. The role of the epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases (RTKs) in provoking biological actions of G protein-coupled receptors (GPCRs) has been one of the most disputed subje...

    Authors: Regina A Oyesanya, Susie Greenbaum, David Dang, Zendra Lee, Abir Mukherjee, Jinhua Wu, Paul Dent and Xianjun Fang
    Citation: Molecular Cancer 2010 9:8
    Content type: Research Published on:

  7. The cyclic AMP (cAMP) signaling pathway has been reported to either promote or suppress cell death, in a cell context-dependent manner. Our previous study has shown that the induction of dynein light chain (DL...

    Authors: Jing Wang, Ruihong Tang, Ming Lv, Jiyan Zhang and Beifen Shen
    Citation: Molecular Cancer 2010 9:6
    Content type: Research Published on:

  8. The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies. However, it rem...

    Authors: Masataka Hirotsu, Takao Setoguchi, Hiromi Sasaki, Yukihiro Matsunoshita, Hui Gao, Hiroko Nagao, Osamu Kunigou and Setsuro Komiya
    Citation: Molecular Cancer 2010 9:5
    Content type: Research Published on:

  9. Increasing amounts of evidence indicate that tumor infiltrating lymphocytes (TIL) are correlated with the prognosis of cancer patients. This study focuses on the association between the densities of tumor infi...

    Authors: Yi-Lan Zhang, Jiang Li, Hao-Yuan Mo, Fang Qiu, Li-Min Zheng, Chao-Nan Qian and Yi-Xin Zeng
    Citation: Molecular Cancer 2010 9:4
    Content type: Research Published on:

  10. While several molecular markers of bladder cancer prognosis have been identified, the limited value of current prognostic markers has created the need for new molecular indicators of bladder cancer outcomes. T...

    Authors: Wun-Jae Kim, Eun-Jung Kim, Seon-Kyu Kim, Yong-June Kim, Yun-Sok Ha, Pildu Jeong, Min-Ju Kim, Seok-Joong Yun, Keon Myung Lee, Sung-Kwon Moon, Sang-Cheol Lee, Eun-Jong Cha and Suk-Chul Bae
    Citation: Molecular Cancer 2010 9:3
    Content type: Research Published on:

  11. It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma. In the present work we investigated whether carnosine also affects tu...

    Authors: Christof Renner, Nadine Zemitzsch, Beate Fuchs, Kathrin D Geiger, Matthias Hermes, Jan Hengstler, Rolf Gebhardt, Jürgen Meixensberger and Frank Gaunitz
    Citation: Molecular Cancer 2010 9:2
    Content type: Research Published on:

  12. The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all EBV-associated tumours, including undifferentiated nasopharyngeal carcinoma (NPC), where it is indispensable for viral replication, genome...

    Authors: Robert Valentine, Christopher W Dawson, Chunfang Hu, Khilan M Shah, Thomas J Owen, Kathryn L Date, Sonia P Maia, Jianyong Shao, John R Arrand, Lawrence S Young and John D O'Neil
    Citation: Molecular Cancer 2010 9:1
    Content type: Research Published on:

  13. The Fanconi anemia (FA) pathway is a multigene DNA damage response network implicated in the repair of DNA lesions that arise during replication or after exogenous DNA damage. The FA pathway displays synthetic...

    Authors: Igor Landais, Sanne Hiddingh, Matthew McCarroll, Chao Yang, Aiming Sun, Mitchell S Turker, James P Snyder and Maureen E Hoatlin
    Citation: Molecular Cancer 2009 8:133
    Content type: Research Published on:

  14. Previously we have shown that B cell receptor (BCR) expression and B cell receptor signaling pathways are important for the basal growth of B lymphoma cells. In particular we have shown that the activation of ...

    Authors: Jiyuan Ke, R Lakshman Chelvarajan, Vishal Sindhava, Darrell A Robertson, Lazaros Lekakis, C Darrell Jennings and Subbarao Bondada
    Citation: Molecular Cancer 2009 8:132
    Content type: Research Published on:

  15. The serine/threonine kinase PKB/Akt plays essential role in various cellular processes including cell growth and proliferation, metabolism and cell survival. The importance of the Akt pathway is highlighted by...

    Authors: Boon Tin Chua, David Gallego-Ortega, Ana Ramirez de Molina, Axel Ullrich, Juan Carlos Lacal and Julian Downward
    Citation: Molecular Cancer 2009 8:131
    Content type: Research Published on:

  16. Despite recent progress in the identification of genetic and molecular alterations in prostate cancer, markers associated with tumor progression are scarce. Therefore precise diagnosis of patients and prognosi...

    Authors: Nicole Chui Pressinotti, Helmut Klocker, Georg Schäfer, Van-Duc Luu, Markus Ruschhaupt, Ruprecht Kuner, Eberhard Steiner, Annemarie Poustka, Georg Bartsch and Holger Sültmann
    Citation: Molecular Cancer 2009 8:130
    Content type: Research Published on:

  17. Curcumin induces apoptosis in many cancer cells and it reduces xenograft growth and the formation of lung metastases in nude mice. Moreover, the plant derived polyphenol has been reported to be able to overcom...

    Authors: Beatrice E Bachmeier, Cristina M Iancu, Peter H Killian, Emanuel Kronski, Valentina Mirisola, Giovanna Angelini, Marianne Jochum, Andreas G Nerlich and Ulrich Pfeffer
    Citation: Molecular Cancer 2009 8:129
    Content type: Research Published on:

  18. Recent studies have implicated aberrant Notch signaling in breast cancers. Yet, relatively little is known about the pattern of expression of various components of the Notch pathway, or its mechanism of action...

    Authors: Suruchi Mittal, Deepa Subramanyam, Devaveena Dey, Rekha V Kumar and Annapoorni Rangarajan
    Citation: Molecular Cancer 2009 8:128
    Content type: Research Published on:

  19. Unknown primary malignancy in the head and neck is not an infrequent diagnosis for patients with metastatic cervical lymph nodes. Although linked with a relatively good prognosis following radiation treatment,...

    Authors: Emma V Barker, Nilva K Cervigne, Patricia P Reis, Rashmi S Goswami, Wei Xu, Ilan Weinreb, Jonathan C Irish and Suzanne Kamel-Reid
    Citation: Molecular Cancer 2009 8:127
    Content type: Short communication Published on:

  20. CXCR4, the receptor for the chemokine stromal-derived factor 1 (SDF-1), has been shown to mediate many of the processes essential for cancer progression such as tumor cell proliferation, metastasis, and angiog...

    Authors: Alex J Carlisle, Christopher A Lyttle, Rosalind Y Carlisle and John M Maris
    Citation: Molecular Cancer 2009 8:126
    Content type: Research Published on:

  21. One of the major reasons for poor prognosis of pancreatic cancer is its high resistance to currently available chemotherapeutic agents. In recent years, focal adhesion kinase (FAK), a central molecule in extra...

    Authors: Wu Huanwen, Liang Zhiyong, Shi Xiaohua, Ren Xinyu, Wang Kai and Liu Tonghua
    Citation: Molecular Cancer 2009 8:125
    Content type: Research Published on:

  22. Tumor development in the human colon is commonly accompanied by epigenetic changes, such as DNA methylation and chromatin modifications. These alterations result in significant, inheritable changes in gene exp...

    Authors: Mirco Menigatti, Elisa Cattaneo, Jacob Sabates-Bellver, Valery V Ilinsky, Philip Went, Federico Buffoli, Victor E Marquez, Josef Jiricny and Giancarlo Marra
    Citation: Molecular Cancer 2009 8:124
    Content type: Research Published on:

  23. Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to targeted therapies, but unfortunately with only limited ...

    Authors: Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean-Jacques Helwig, Didier Jacqmin, Hervé Lang and Thierry Massfelder
    Citation: Molecular Cancer 2009 8:123
    Content type: Research Published on:

  24. Past studies have shown that sensitivity of melanoma cells to TRAIL-induced apoptosis is largely correlated with the expression levels of TRAIL death receptors on the cell surface. However, fresh melanoma isol...

    Authors: Hao Liu, Chen Chen Jiang, Christopher J Lavis, Amanda Croft, Li Dong, Hsin-Yi Tseng, Fan Yang, Kwang Hong Tay, Peter Hersey and Xu Dong Zhang
    Citation: Molecular Cancer 2009 8:122
    Content type: Research Published on:

  25. Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in the progression of prostate, breast, endometrial and leukemic cancers. This is due to the ability of AKR1C enzym...

    Authors: Pedro Veliça, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride and Chris M Bunce
    Citation: Molecular Cancer 2009 8:121
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2010 9:21

  26. Insulin-like growth factor binding protein (IGFBP-3) is an antiproliferative, pro-apoptotic and invasion suppressor protein which is transcriptionally regulated by p53. Promoter methylation has been linked to ...

    Authors: Pao-Ling Torng, Ching-Wei Lin, Michael WY Chan, Hui-Wen Yang, Su-Cheng Huang and Chin-Tarng Lin
    Citation: Molecular Cancer 2009 8:120
    Content type: Research Published on:

  28. Osteosarcoma (OS) is the most common primary bone tumour in children and young adults. Despite improved prognosis, metastatic or relapsed OS remains largely incurable and no significant improvement has been ob...

    Authors: Ymera Pignochino, Giovanni Grignani, Giuliana Cavalloni, Manuela Motta, Marta Tapparo, Stefania Bruno, Alessia Bottos, Loretta Gammaitoni, Giorgia Migliardi, Giovanni Camussi, Marco Alberghini, Bruno Torchio, Stefano Ferrari, Federico Bussolino, Franca Fagioli, Piero Picci…
    Citation: Molecular Cancer 2009 8:118
    Content type: Research Published on:

  29. Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments. HIF-1 is composed of two subunits: hypoxia-inducible HIF-1α ...

    Authors: Menghang Xia, Kun Bi, Ruili Huang, Ming-Hsuang Cho, Srilatha Sakamuru, Susanne C Miller, Hua Li, Yi Sun, John Printen, Christopher P Austin and James Inglese
    Citation: Molecular Cancer 2009 8:117
    Content type: Research Published on:

  30. CD1d-restricted iNKT cells are protective against murine melanoma B16F10-Nex2 growing subcutaneously in syngeneic C57Bl/6 mice as inferred from the fast tumor development in CD1d-KO in comparison with wild typ...

    Authors: Bianca R Dias, Elaine G Rodrigues, Leonardo Nimrichter, Ernesto S Nakayasu, Igor C Almeida and Luiz R Travassos
    Citation: Molecular Cancer 2009 8:116
    Content type: Research Published on:

  31. MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this ...

    Authors: Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang and Ayad M Al-Katib
    Citation: Molecular Cancer 2009 8:115
    Content type: Research Published on:

  32. Membrane androgen receptors (mAR) have been implicated in the regulation of cell growth, motility and apoptosis in prostate and breast cancer. Here we analyzed mAR expression and function in colon cancer.

    Authors: Shuchen Gu, Natalia Papadopoulou, Eva-Maria Gehring, Omaima Nasir, Konstantinos Dimas, Shefalee K Bhavsar, Michael Föller, Konstantinos Alevizopoulos, Florian Lang and Christos Stournaras
    Citation: Molecular Cancer 2009 8:114
    Content type: Research Published on:

  33. Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors. The GLI1 oncogene is believed to play a role in the genesis of these tumors. We...

    Authors: Andrea Watson, Paul Kent, Murad Alam, Amy S Paller, David M Umbach, Joon Won Yoon, Philip M Iannaccone and David O Walterhouse
    Citation: Molecular Cancer 2009 8:113
    Content type: Research Published on:

  34. The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inh...

    Authors: Ling Yang, Jing He, Shuhong Huang, Xiaoli Zhang, Yuehong Bian, Nonggao He, Hongwei Zhang and Jingwu Xie
    Citation: Molecular Cancer 2009 8:112
    Content type: Short communication Published on:

  35. TGF-β resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastat...

    Authors: Yongsheng Ren, Liyu Wu, Andra R Frost, William Grizzle, Xu Cao and Mei Wan
    Citation: Molecular Cancer 2009 8:111
    Content type: Research Published on:

  36. Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyros...

    Authors: Lirong Peng, Xiaofang Xing, Weijun Li, Like Qu, Lin Meng, Shenyi Lian, Beihai Jiang, Jian Wu and Chengchao Shou
    Citation: Molecular Cancer 2009 8:110
    Content type: Research Published on:

  37. Recent evidence suggests that estrogen signaling may be involved in the pathogenesis of non-small cell lung cancer (NSCLC). Aromatase is an enzyme complex that catalyses the final step in estrogen synthesis an...

    Authors: Angelos Koutras, Efstathia Giannopoulou, Ismini Kritikou, Anna Antonacopoulou, TR Jeffry Evans, Athanasios G Papavassiliou and Haralabos Kalofonos
    Citation: Molecular Cancer 2009 8:109
    Content type: Research Published on:

  38. Doxorubicin is one of the few chemotherapeutic drugs able to exert both cytotoxic and pro-immunogenic effects against cancer cells. Following the drug administration, the intracellular protein calreticulin is ...

    Authors: Sara De Boo, Joanna Kopecka, Davide Brusa, Elena Gazzano, Lina Matera, Dario Ghigo, Amalia Bosia and Chiara Riganti
    Citation: Molecular Cancer 2009 8:108
    Content type: Research Published on:

  39. Therapeutic strategies exist for human pulmonary neoplasia, however due to the heterogeneity of the disease, most are not very effective. The innate immunity gene, toll-like receptor 4 (TLR4), protects against...

    Authors: Alison K Bauer, Jennifer Fostel, Laura M Degraff, Elizabeth A Rondini, Christopher Walker, Sherry F Grissom, Julie Foley and Steven R Kleeberger
    Citation: Molecular Cancer 2009 8:107
    Content type: Research Published on:

  40. Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models. More directl...

    Authors: Aaron E Foster, Fatma V Okur, Ettore Biagi, An Lu, Gianpietro Dotti, Eric Yvon, Barbara Savoldo, George Carrum, Michael Andreeff, Margaret A Goodell, Helen E Heslop and Malcolm K Brenner
    Citation: Molecular Cancer 2009 8:106
    Content type: Short communication Published on:

  41. With the aim to simplify cancer management, cancer research lately dedicated itself more and more to discover and develop non-invasive biomarkers. In this connection, circulating cell-free DNA (ccf DNA) seems ...

    Authors: Corina Kohler, Ramin Radpour, Zeinab Barekati, Reza Asadollahi, Johannes Bitzer, Edward Wight, Nicole Bürki, Claude Diesch, Wolfgang Holzgreve and Xiao Yan Zhong
    Citation: Molecular Cancer 2009 8:105
    Content type: Research Published on:

  42. Hypoxia inducible factor-1 alpha (HIF-1α) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1α protein stabilizes and transactivates genes involved in adaptation to hypoxic c...

    Authors: Caroline N Mills, Sandeep S Joshi and Richard M Niles
    Citation: Molecular Cancer 2009 8:104
    Content type: Research Published on:

  43. p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, se...

    Authors: Peixin Dong, Zhujie Xu, Nan Jia, Dajin Li and Youji Feng
    Citation: Molecular Cancer 2009 8:103
    Content type: Research Published on:

  45. An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...

    Authors: Therese Bredholt, Elizabeth AO Dimba, Hanne R Hagland, Line Wergeland, Jørn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr and Bjørn T Gjertsen
    Citation: Molecular Cancer 2009 8:101
    Content type: Research Published on:

  46. The chemopreventive effects of dietary phytochemicals on malignant tumors have been studied extensively because of a relative lack of toxicity. To achieve desirable effects, however, treatment with a single ag...

    Authors: Yoshitaka Nakamura, Shingo Yogosawa, Yasuyuki Izutani, Hirotsuna Watanabe, Eigo Otsuji and Tosiyuki Sakai
    Citation: Molecular Cancer 2009 8:100
    Content type: Research Published on:

  47. Imatinib mesylate has significantly improved survival and quality of life of patients with gastrointestinal stromal tumors (GISTs). However, the molecular mechanism through which imatinib exerts its anti-tumor...

    Authors: Jheri J Dupart, Jonathan C Trent, Ho-Young Lee, Kenneth R Hess, Andrew K Godwin, Takahiro Taguchi and Wei Zhang
    Citation: Molecular Cancer 2009 8:99
    Content type: Research Published on:

  48. PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (P...

    Authors: Catherine Fan, Lizhi He, Anil Kapoor, Adrian P Rybak, Jason De Melo, Jean-Claude Cutz and Damu Tang
    Citation: Molecular Cancer 2009 8:98
    Content type: Research Published on:

  49. Based on its role in angiogenesis and apoptosis, the inhibition of NFκB activity is considered an effective treatment for cancer, hampered by the lack of selective and safe inhibitors. We recently demonstrated...

    Authors: Daniela Sorriento, Alfonso Campanile, Gaetano Santulli, Eleonora Leggiero, Lucio Pastore, Bruno Trimarco and Guido Iaccarino
    Citation: Molecular Cancer 2009 8:97
    Content type: Research Published on:

  50. A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer. It has been suggested that the mechanism of this associatio...

    Authors: Ludmila Prokunina-Olsson and Jennifer L Hall
    Citation: Molecular Cancer 2009 8:96
    Content type: Short communication Published on:
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Molecular Cancer

ISSN: 1476-4598