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  1. Content type: Research

    Apoptosis-stimulating of p53 protein 2 (ASPP2) is one of the ASPP family members and it has been reported to be associated with human cancer. However, the role of it in pancreatic cancer is still not clear.

    Authors: Bin Song, Qi Bian, Yi-Jie Zhang, Cheng-Hao Shao, Gang Li, An-An Liu, Wei Jing, Rui Liu, Ying-Qi Zhou, Gang Jin and Xian-Gui Hu

    Citation: Molecular Cancer 2015 14:177

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  2. Content type: Short communication

    In multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to sympt...

    Authors: Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan and Chor Sang Chim

    Citation: Molecular Cancer 2015 14:175

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  3. Content type: Research

    The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is appar...

    Authors: Tien-Jen Lin, Hsin-Ting Lin, Wei-Ting Chang, Pradeep Mitapalli. S, Pei-Wen Hsiao, Shu-Yi Yin and Ning-Sun Yang

    Citation: Molecular Cancer 2015 14:174

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  4. Content type: Research

    Molecular iodine (I2) exhibits antiproliferative and apoptotic effects on in vivo and in vitro cancer models. These effects are thought to be mediated by an iodinated arachidonic acid derivative, 6-iodolactone (6...

    Authors: Mario Nava-Villalba, Rosa E. Nuñez-Anita, Alexander Bontempo and Carmen Aceves

    Citation: Molecular Cancer 2015 14:168

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  5. Content type: Research

    Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and its role in pathogenesis of HCC remain largely unknown.

    Authors: Qi-fei Tao, Sheng-xian Yuan, Fu Yang, Sen Yang, Yuan Yang, Ji-hang Yuan, Zhen-guang Wang, Qing-guo Xu, Kong-ying Lin, Jie Cai, Jian Yu, Wei-long Huang, Xiao-lei Teng, Chuan-chuan Zhou, Fang Wang, Shu-han Sun…

    Citation: Molecular Cancer 2015 14:170

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  6. Content type: Research

    The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain uncl...

    Authors: Helen B. Pearson, Edwina McGlinn, Toby J. Phesse, Holger Schlüter, Anuratha Srikumar, Nathan J. Gödde, Christina B. Woelwer, Andrew Ryan, Wayne A. Phillips, Matthias Ernst, Pritinder Kaur and Patrick Humbert

    Citation: Molecular Cancer 2015 14:169

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  7. Content type: Research

    Genetic alterations in tricarboxylic acid (TCA) cycle metabolic enzymes were recently linked to various cancers. However, the associations of single nucleotide polymorphisms (SNPs) in genes of these enzymes ha...

    Authors: Guanglong Dong, Xianli He, Yibing Chen, Haiyan Cao, Jiaojiao Wang, Xiaonan Liu, Shukui Wang, Shaogui Wan and Jinliang Xing

    Citation: Molecular Cancer 2015 14:171

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  8. Content type: Research

    The SWI/SNF ATP dependent chromatin remodeling complex is a multi-subunit complex, conserved in eukaryotic evolution that facilitates nucleosomal re-positioning relative to the DNA sequence. In recent years th...

    Authors: Jonatan Darr, Agnes Klochendler, Sara Isaac, Tami Geiger and Amir Eden

    Citation: Molecular Cancer 2015 14:167

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    The Erratum to this article has been published in Molecular Cancer 2016 15:14

  9. Content type: Research

    Although a relatively small proportion of all breast cancer (BC), triple negative (TN) BC is responsible for a relatively large proportion of BC deaths because of its worse clinical outcome. To investigate whe...

    Authors: Sei Sai, Guillaume Vares, Eun Ho Kim, Kumiko Karasawa, Bing Wang, Mitsuru Nenoi, Yoshiya Horimoto and Mitsuhiro Hayashi

    Citation: Molecular Cancer 2015 14:166

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  10. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lnc...

    Authors: Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu, Pei Ma and Yong-qian Shu

    Citation: Molecular Cancer 2015 14:165

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  11. Content type: Research

    Previous studies have established that levels of the Inhibitor of Growth 1(ING1) tumor suppressor are reduced in a significant proportion of different cancer types. Here we analyzed levels of ING1 in breast ca...

    Authors: Satbir Thakur, Arash Nabbi, Alexander Klimowicz and Karl Riabowol

    Citation: Molecular Cancer 2015 14:164

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  12. Content type: Research

    microRNA-122 (miR-122) is the most abundant and specific miRNA in the liver. It acts as an important tumor suppressor in hepatocellular carcinoma (HCC) through regulating its target genes, but details of its o...

    Authors: Jialin He, Kai Zhao, Lu Zheng, Zhizhen Xu, Wei Gong, Shan Chen, Xiaodong Shen, Gang Huang, Min Gao, Yijun Zeng, Yan Zhang and Fengtian He

    Citation: Molecular Cancer 2015 14:163

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  13. Content type: Research

    Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, ...

    Authors: Moitri Basu, Rahul Bhattacharya, Upasana Ray, Satinath Mukhopadhyay, Uttara Chatterjee and Sib Sankar Roy

    Citation: Molecular Cancer 2015 14:162

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  14. Content type: Research

    Glioblastoma (GBM) is the most common primary brain malignancy and confers a dismal prognosis. GBMs harbor glioblastoma-initiating cells (GICs) that drive tumorigenesis and contribute to therapeutic resistance...

    Authors: Awais A. Mughal, Zanina Grieg, Håvard Skjellegrind, Artem Fayzullin, Mustapha Lamkhannat, Mrinal Joel, M. Shakil Ahmed, Wayne Murrell, Einar O. Vik-Mo, Iver A. Langmoen and Biljana Stangeland

    Citation: Molecular Cancer 2015 14:160

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  15. Content type: Research

    The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a co...

    Authors: Seung Joon Lee, Alisa Litan, Zhiqin Li, Bruce Graves, Stephan Lindsey, Sonali P. Barwe and Sigrid A. Langhans

    Citation: Molecular Cancer 2015 14:159

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  16. Content type: Research

    Migration and invasion enhancer 1 (MIEN1) is a novel gene found to be abundantly expressed in breast tumor tissues and functions as a critical regulator of tumor cell migration and invasion to promote systemic...

    Authors: Marilyne Kpetemey, Subhamoy Dasgupta, Smrithi Rajendiran, Susobhan Das, Lee D. Gibbs, Praveenkumar Shetty, Zygmunt Gryczynski and Jamboor K. Vishwanatha

    Citation: Molecular Cancer 2015 14:156

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  17. Content type: Research

    CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells...

    Authors: Alice Conigliaro, Viviana Costa, Alessia Lo Dico, Laura Saieva, Simona Buccheri, Francesco Dieli, Mauro Manno, Samuele Raccosta, Carmine Mancone, Marco Tripodi, Giacomo De Leo and Riccardo Alessandro

    Citation: Molecular Cancer 2015 14:155

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  18. Content type: Research

    Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particul...

    Authors: TB Rounge, K Furu, RI Skotheim, TB Haugen, T Grotmol and E Enerly

    Citation: Molecular Cancer 2015 14:153

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  19. Content type: Research

    High grade epithelial ovarian cancer (EOC) is commonly characterised by widespread peritoneal dissemination and ascites. Metastatic EOC tumour cells can attach directly to neighbouring organs or alternatively,...

    Authors: Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay and Nuzhat Ahmed

    Citation: Molecular Cancer 2015 14:152

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  20. Content type: Research

    Chromodomain-helicase DNA binding protein 5 (CHD5) is an important tumor suppressor gene deleted from 1p36.31 in neuroblastomas (NBs). High CHD5 expression is associated with a favorable prognosis, but deletio...

    Authors: Mayumi Higashi, Venkatadri Kolla, Radhika Iyer, Koumudi Naraparaju, Tiangang Zhuang, Sriharsha Kolla and Garrett M. Brodeur

    Citation: Molecular Cancer 2015 14:150

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  21. Content type: Research

    Synovial sarcoma account for approximately 10 % of all soft-tissue tumors and occur most frequently in young adults. A specific translocation in this sarcoma induces fusion of the SYT gene on chromosome 18 to ...

    Authors: Alba Fricke, Prisca V. Ullrich, Jürgen Heinz, Dietmar Pfeifer, Jutta Scholber, Georg W. Herget, Oliver Hauschild, Peter Bronsert, G. Björn Stark, Holger Bannasch, Steffen U. Eisenhardt and David Braig

    Citation: Molecular Cancer 2015 14:151

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  22. Content type: Research

    The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 expression in this group of patients is still ...

    Authors: Abdullah Alsuliman, Dilek Colak, Olfat Al-Harazi, Hanaa Fitwi, Asma Tulbah, Taher Al-Tweigeri, Monther Al-Alwan and Hazem Ghebeh

    Citation: Molecular Cancer 2015 14:149

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  23. Content type: Research

    The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung meta...

    Authors: María Contador-Troca, Alberto Alvarez-Barrientos, Jaime M. Merino, Antonio Morales-Hernández, María I. Rodríguez, Javier Rey-Barroso, Eva Barrasa, María I. Cerezo-Guisado, Inmaculada Catalina-Fernández, Javier Sáenz-Santamaría, Francisco J. Oliver and Pedro M. Fernandez-Salguero

    Citation: Molecular Cancer 2015 14:148

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  24. Content type: Review

    The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success ...

    Authors: Antonio Palumbo Jr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto and Luiz Eurico Nasciutti

    Citation: Molecular Cancer 2015 14:145

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  25. Content type: Research

    Combined treatment of oncolytic adenoviruses with chemotherapeutic agents is foreseen as a therapeutic option for cancer. Here we have investigated the potential to use gemcitabine in combination with the onco...

    Authors: Maria Victoria Maliandi, Ana Mato-Berciano, Luciano Sobrevals, Gaël Roué, Anabel José and Cristina Fillat

    Citation: Molecular Cancer 2015 14:146

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  26. Content type: Research

    Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screeni...

    Authors: Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth and Ralph Minter

    Citation: Molecular Cancer 2015 14:147

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  27. Content type: Erratum

    Authors: Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis…

    Citation: Molecular Cancer 2015 14:144

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    The original article was published in Molecular Cancer 2015 14:94

  28. Content type: Research

    Dystroglycan (DG) is a cell-surface laminin receptor that links the cytoskeleton to the extracellular matrix in a variety of epithelial tissues. Its function as a matrix receptor requires extensive glycosylati...

    Authors: Michael R. Miller, Deqin Ma, James Schappet, Patrick Breheny, Sarah L. Mott, Nadine Bannick, Eric Askeland, James Brown and Michael D. Henry

    Citation: Molecular Cancer 2015 14:141

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  29. Content type: Research

    Hypoxia can halt cell cycle progression of several cell types at the G1/S interface. The arrest needs to be overcome by cancer cells. We have previously shown that the hypoxia-inducible cellular oxygen sensor ...

    Authors: Heidi Högel, Petra Miikkulainen, Lucia Bino and Panu M. Jaakkola

    Citation: Molecular Cancer 2015 14:143

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  30. Content type: Short communication

    Adenocarcinoma in situ (AIS) of the lung has an extremely favorable prognosis. However, early but invasive adenocarcinoma (eIA) sometimes has a fatal outcome. We had previously compared the expression profiles...

    Authors: Aya Shiba-Ishii, Yunjung Kim, Toshihiro Shiozawa, Shinji Iyama, Kaishi Satomi, Junko Kano, Shingo Sakashita, Yukio Morishita and Masayuki Noguchi

    Citation: Molecular Cancer 2015 14:142

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  31. Content type: Research

    The epidermal growth factor (EGF) family of ligands has been implicated in promoting breast cancer initiation, growth and progression. The contributions of EGF family ligands and their receptors to breast canc...

    Authors: Mariya Farooqui, Laura R. Bohrer, Nicholas J. Brady, Pavlina Chuntova, Sarah E. Kemp, C. Taylor Wardwell, Andrew C. Nelson and Kathryn L. Schwertfeger

    Citation: Molecular Cancer 2015 14:138

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  32. Content type: Research

    Characterization of molecular mechanisms underpinning development of pancreatic ductal adenocarcinoma (PDAC) may lead to the identification of novel therapeutic targets and biomarkers. SgK223, also known as Pr...

    Authors: Carole M. Tactacan, Yu Wei Phua, Ling Liu, Luxi Zhang, Emily S. Humphrey, Mark Cowley, Mark Pinese, Andrew V. Biankin and Roger J. Daly

    Citation: Molecular Cancer 2015 14:139

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  33. Content type: Research

    An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In t...

    Authors: Ni Chen, Meiping Ren, Rong Li, Xin Deng, Yongjie Li, Kai Yan, Lamei Xiao, Yan Yang, Liqun Wang, Mao Luo, William P. Fay and Jianbo Wu

    Citation: Molecular Cancer 2015 14:140

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  34. Content type: Research

    Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is a...

    Authors: Ling Ling, Si Kee Tan, Ting Hwee Goh, Edwin Cheung, Victor Nurcombe, Andre J. van Wijnen and Simon M. Cool

    Citation: Molecular Cancer 2015 14:136

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  35. Content type: Research

    Urinary bladder cancer is one of the most fatal and expensive diseases of industrialized world. Despite the strenuous efforts, no seminal advances have been achieved for its clinical management. Given the impo...

    Authors: Eumorphia G. Konstantakou, Gerassimos E. Voutsinas, Athanassios D. Velentzas, Aggeliki-Stefania Basogianni, Efthimios Paronis, Evangelos Balafas, Nikolaos Kostomitsopoulos, Konstantinos N. Syrigos, Ema Anastasiadou and Dimitrios J. Stravopodis

    Citation: Molecular Cancer 2015 14:135

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  36. Content type: Short communication

    Glioblastoma (GBM) is the most frequent and aggressive type of adult brain tumor. Most GBMs express telomerase; a high level of intra-tumoral telomerase activity (TA) is predictive of poor prognosis. Thus, tel...

    Authors: Sylvain Ferrandon, Céline Malleval, Badia El Hamdani, Priscillia Battiston-Montagne, Radu Bolbos, Jean-Baptiste Langlois, Patrick Manas, Sergei M Gryaznov, Gersende Alphonse, Jérôme Honnorat, Claire Rodriguez-Lafrasse and Delphine Poncet

    Citation: Molecular Cancer 2015 14:134

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  37. Content type: Research

    Docosahexaenoic acid (DHA) is a natural compound with anticancer and anti-angiogenesis activity that is currently under investigation as both a preventative agent and an adjuvant to breast cancer therapy. Howe...

    Authors: Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley and Wei-Qun Ding

    Citation: Molecular Cancer 2015 14:133

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  38. Content type: Research

    Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (B...

    Authors: Nitesh Sharma, Vera Magistroni, Rocco Piazza, Stefania Citterio, Caterina Mezzatesta, Praveen Khandelwal, Alessandra Pirola and Carlo Gambacorti-Passerini

    Citation: Molecular Cancer 2015 14:132

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  39. Content type: Research

    Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore t...

    Authors: Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg and Khawla S. Al-Kuraya

    Citation: Molecular Cancer 2015 14:131

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  40. Content type: Research

    Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten ...

    Authors: Francesca De Amicis, Saveria Aquila, Catia Morelli, Carmela Guido, Marta Santoro, Ida Perrotta, Loredana Mauro, Francesca Giordano, Alessandra Nigro, Sebastiano Andò and Maria L. Panno

    Citation: Molecular Cancer 2015 14:130

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  41. Content type: Research

    Clinical trials designed to test the efficacy of retinoic acid (RA) as an adjuvant for the treatment of solid cancers have been disappointing, primarily due to RA resistance. Estrogen receptor (ER)-negative br...

    Authors: Rong-Zong Liu, Elizabeth Garcia, Darryl D. Glubrecht, Ho Yin Poon, John R. Mackey and Roseline Godbout

    Citation: Molecular Cancer 2015 14:129

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  42. Content type: Erratum

    Authors: Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo and Antoni Ribas

    Citation: Molecular Cancer 2015 14:128

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    The original article was published in Molecular Cancer 2014 13:194

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