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  1. Content type: Review

    Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion ...

    Authors: Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang and Ming Zeng

    Citation: Molecular Cancer 2017 16:54

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  2. Content type: Research

    Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of car...

    Authors: Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li…

    Citation: Molecular Cancer 2017 16:53

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  3. Content type: Research

    Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Authors: Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang

    Citation: Molecular Cancer 2017 16:51

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  4. Content type: Review

    The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Authors: Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li

    Citation: Molecular Cancer 2017 16:52

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  5. Content type: Research

    Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates th...

    Authors: Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song and Luhua Wang

    Citation: Molecular Cancer 2017 16:50

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  6. Content type: Short communication

    Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly u...

    Authors: S. T. Lwin, J. A. Fowler, M. T. Drake, J. R. Edwards, C. C. Lynch and C. M. Edwards

    Citation: Molecular Cancer 2017 16:49

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  7. Content type: Research

    Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinica...

    Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu

    Citation: Molecular Cancer 2017 16:48

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  8. Content type: Letter to the Editor

    Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are de...

    Authors: Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone and Giuseppe Gasparre

    Citation: Molecular Cancer 2017 16:47

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  9. Content type: Research

    Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during th...

    Authors: Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang and Haiyan Chu

    Citation: Molecular Cancer 2017 16:46

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  10. Content type: Review

    It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted ...

    Authors: Claudia Gasch, Brendan Ffrench, John J. O’Leary and Michael F. Gallagher

    Citation: Molecular Cancer 2017 16:43

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  11. Content type: Research

    Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Authors: Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…

    Citation: Molecular Cancer 2017 16:44

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  12. Content type: Research

    Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported ...

    Authors: Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C. Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A. López-Martín and M. Teresa Agulló-Ortuño

    Citation: Molecular Cancer 2017 16:45

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  13. Content type: Review

    Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports h...

    Authors: Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Citation: Molecular Cancer 2017 16:42

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  14. Content type: Research

    Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early...

    Authors: Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang and Guozhong Ji

    Citation: Molecular Cancer 2017 16:39

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  15. Content type: Review

    Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-rene...

    Authors: Komal Qureshi-Baig, Pit Ullmann, Serge Haan and Elisabeth Letellier

    Citation: Molecular Cancer 2017 16:40

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  16. Content type: Research

    Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain...

    Authors: Mansi Shah, Ryan Cardenas, Belinda Wang, Jenny Persson, Nigel P. Mongan, Anna Grabowska and Cinzia Allegrucci

    Citation: Molecular Cancer 2017 16:38

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  17. Content type: Review

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Authors: Pramudita R. Prasetyanti and Jan Paul Medema

    Citation: Molecular Cancer 2017 16:41

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  18. Content type: Research

    Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Recently, the deregulated expression of full-length ALK has bee...

    Authors: H Inoue, M Hashimura, M Akiya, R Chiba and M Saegusa

    Citation: Molecular Cancer 2017 16:37

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  19. Content type: Research

    We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increa...

    Authors: Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis and David N. Brindley

    Citation: Molecular Cancer 2017 16:36

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  20. Content type: Research

    Hypoxia plays an important role in the development of various cancers. MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and modulate the tumorigenesis, including gastric cancer. How...

    Authors: Chuan He, Libo Wang, Jiantao Zhang and Hong Xu

    Citation: Molecular Cancer 2017 16:35

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  21. Content type: Research

    CD73 (ecto-5′-nucleotidase) is implicated in the development of many types of cancer. CD73 inhibitors are currently being tested in clinical trials for the treatment of cancer. Understanding the molecular and ...

    Authors: Jianjie Zhu, Yuanyuan Zeng, Wei Li, Hualong Qin, Zhe Lei, Dan Shen, Dongmei Gu, Jian-an Huang and Zeyi Liu

    Citation: Molecular Cancer 2017 16:34

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  22. Content type: Research

    Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linke...

    Authors: Rehan Ahmad, Maroof Alam, Masanori Hasegawa, Yasumitsu Uchida, Omar Al-Obaid, Surender Kharbanda and Donald Kufe

    Citation: Molecular Cancer 2017 16:33

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  23. Content type: Review

    The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Authors: Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass

    Citation: Molecular Cancer 2017 16:28

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  24. Content type: Review

    Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Citation: Molecular Cancer 2017 16:29

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  25. Content type: Research

    More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Authors: Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen

    Citation: Molecular Cancer 2017 16:30

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