Skip to main content

Articles

Page 3 of 51

  1. Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and ...

    Authors: Haiyang Zhang, Ting Deng, Rui Liu, Tao Ning, Haiou Yang, Dongying Liu, Qiumo Zhang, Dan Lin, Shaohua Ge, Ming Bai, Xinyi Wang, Le Zhang, Hongli Li, Yuchong Yang, Zhi Ji, Hailong Wang…

    Citation: Molecular Cancer 2020 19:43

    Content type: Research

    Published on:

  2. The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macropha...

    Authors: Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, Wenming Cui and Xudong Jia

    Citation: Molecular Cancer 2020 19:41

    Content type: Research

    Published on:

  3. The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human ...

    Authors: Dan Jin, Jiwei Guo, Yan Wu, Lijuan Yang, Xiaohong Wang, Jing Du, Juanjuan Dai, Weiwei Chen, Kaikai Gong, Shuang Miao, Xuelin Li and Hongliang Sun

    Citation: Molecular Cancer 2020 19:40

    Content type: Research

    Published on:

  4. Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implicati...

    Authors: Yuqing Wu, Siwei Zhang, Xiaoxiao Gong, Samantha Tam, Desheng Xiao, Shuang Liu and Yongguang Tao

    Citation: Molecular Cancer 2020 19:39

    Content type: Review

    Published on:

  5. Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modif...

    Authors: Weicheng Liang, Zexiao Lin, Cong Du, Dongbo Qiu and Qi Zhang

    Citation: Molecular Cancer 2020 19:38

    Content type: Review

    Published on:

  6. Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, ...

    Authors: Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur and Surinder K. Batra

    Citation: Molecular Cancer 2020 19:37

    Content type: Research

    Published on:

  7. Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully eluc...

    Authors: Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory and Pierre-François Cartron

    Citation: Molecular Cancer 2020 19:36

    Content type: Research

    Published on:

  8. The activation of NF-κB signaling pathway is regarded as the dominant process that correlates with tumorigenesis. Recently, increasing evidence shows that long noncoding RNAs (lncRNAs) play crucial roles in su...

    Authors: Xiaofan Ren, Changhao Chen, Yuming Luo, Mingyang Liu, Yuting Li, Shangyou Zheng, Huilin Ye, Zhiqiang Fu, Min Li, Zhihua Li and Rufu Chen

    Citation: Molecular Cancer 2020 19:35

    Content type: Research

    Published on:

  9. CircRNAs are a class of single-stranded RNA molecules with a covalently closed loop structure and have been characterized by high stability, abundance, conservation, and display tissue/developmental stage-spec...

    Authors: Jikui Sun, Banban Li, Chang Shu, Quanfeng Ma and Jinhuan Wang

    Citation: Molecular Cancer 2020 19:34

    Content type: Review

    Published on:

  10. Circular RNAs (circRNAs), a new type of noncoding RNA (ncRNA), have been identified as significant gene expression regulators and are involved in cancer progression. However, the roles of circRNAs in nasophary...

    Authors: Xiaohong Hong, Na Liu, Yelin Liang, Qingmei He, Xiaojing Yang, Yuan Lei, Panpan Zhang, Yin Zhao, Shiwei He, Yaqin Wang, Junyan Li, Qian Li, Jun Ma and Yingqin Li

    Citation: Molecular Cancer 2020 19:33

    Content type: Research

    Published on:

  11. Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional treatments, although a limited number of early-stage patients can undergo radical resection. Immunotherapies for the trea...

    Authors: Jia-qiao Fan, Meng-Fei Wang, Hai-Long Chen, Dong Shang, Jugal K. Das and Jianxun Song

    Citation: Molecular Cancer 2020 19:32

    Content type: Review

    Published on:

  12. Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification an...

    Authors: Ming Lei, Guantao Zheng, Qianqian Ning, Junnian Zheng and Dong Dong

    Citation: Molecular Cancer 2020 19:30

    Content type: Review

    Published on:

  13. Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these pa...

    Authors: Ranjana K. Kanchan, Jawed A. Siddiqui, Sidharth Mahapatra, Surinder K. Batra and Mohd W. Nasser

    Citation: Molecular Cancer 2020 19:29

    Content type: Review

    Published on:

  14. After publication of the article [1], authors found out that Fig. 1 was inadvertently replaced.

    Authors: Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li…

    Citation: Molecular Cancer 2020 19:31

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2020 19:19

  15. Accumulating evidence shows that long noncoding RNAs (lncRNAs) are important regulator molecules involved in diverse biological processes. Acquired drug resistance is a major challenge in the clinical treatmen...

    Authors: Chenfei Lu, Yutian Wei, Xiefeng Wang, Zhuoran Zhang, Jianxing Yin, Wentao Li, Lijiu Chen, Xiao Lyu, Zhumei Shi, Wei Yan and Yongping You

    Citation: Molecular Cancer 2020 19:28

    Content type: Research

    Published on:

  16. Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) pl...

    Authors: Mingli Han, Yuanting Gu, Pengwei Lu, Jingyi Li, Hui Cao, Xiangke Li, Xueke Qian, Chao Yu, Yunqing Yang, Xue Yang, Na Han, Dongwei Dou, Jianguo Hu and Huaying Dong

    Citation: Molecular Cancer 2020 19:26

    Content type: Research

    Published on:

  17. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are potential biomarkers and key regulators of tumour development and progression. SOX2 overlapping transcript (SOX2OT) is a novel lncRNA tha...

    Authors: Yonghao Zhan, Zhicong Chen, Shiming He, Yanqing Gong, Anbang He, Yifan Li, Lianghao Zhang, Xuepei Zhang, Dong Fang, Xuesong Li and Liqun Zhou

    Citation: Molecular Cancer 2020 19:25

    Content type: Research

    Published on:

  18. After the publication of this work [1], the authors noticed that the affiliations were incorrectly provided. Updated affiliation section is provided in this paper.

    Authors: Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun and Qiuhui Pan

    Citation: Molecular Cancer 2020 19:24

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:188

  19. Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun...

    Authors: Pan Wu, Yongzhen Mo, Miao Peng, Ting Tang, Yu Zhong, Xiangying Deng, Fang Xiong, Can Guo, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong

    Citation: Molecular Cancer 2020 19:22

    Content type: Review

    Published on:

  20. After the publication of this work [1], an error was found in Fig. 1b. As described in the Results section that circ0084003 has 13 exons, it should be formed by 5–17 (13exons) exons, authors have described “fo...

    Authors: Peng-Fei Zhang, Xu Pei, Ke-Sang Li, Li-Na Jin, Fei Wang, Jing Wu and Xue-Mei Zhang

    Citation: Molecular Cancer 2020 19:21

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:179

  21. Accumulating evidence indicates that circular RNAs (circRNAs) act as microRNA (miRNA) sponges to directly inhibit specific miRNAs and alter their ability to regulate gene expression at the post-transcriptional...

    Authors: Xiangyu Jian, Han He, Jiehong Zhu, Qi Zhang, Zhongxin Zheng, Xiangjing Liang, Liuyan Chen, Meiling Yang, Kaiyue Peng, Zhaowen Zhang, Tengfei Liu, Yaping Ye, Hongli Jiao, Shuyang Wang, Weijie Zhou, Yanqing Ding…

    Citation: Molecular Cancer 2020 19:20

    Content type: Research

    Published on:

  22. Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a variety of tumors, but resistance during treatment is a major issue. In this review, we describe the utility of PD-L1 exp...

    Authors: Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li…

    Citation: Molecular Cancer 2020 19:19

    Content type: Review

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:31

  23. Accumulating literatures have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers that play key roles in tumor development and progression. Urothelial cancer associated 1 (UCA1) is a novel l...

    Authors: Wei Wang, Wentao Hu, Ya Wang, Yong An, Lei Song, Panfeng Shang and Zhongjin Yue

    Citation: Molecular Cancer 2020 19:18

    Content type: Research

    Published on:

  24. Recent evidences have shown that circular RNAs (circRNAs) are frequently dysregulated and play paramount roles in various cancers. circRNAs are abundant in central nervous system (CNS); however, few studies de...

    Authors: Jiehua He, Zuoyu Huang, Mingliang He, Jianyou Liao, Qianqian Zhang, Shengwen Wang, Lin Xie, Leping Ouyang, H. Phillip Koeffler, Dong Yin and Anmin Liu

    Citation: Molecular Cancer 2020 19:17

    Content type: Research

    Published on:

  25. Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time ...

    Authors: Martin P. Barr, Steven G. Gray, Kathy Gately, Emily Hams, Padraic G. Fallon, Anthony Mitchell Davies, Derek J. Richard, Graham P. Pidgeon and Kenneth J. O’Byrne

    Citation: Molecular Cancer 2020 19:16

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2015 14:45

  26. Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells (CTCs) are shed into the bloodstream from either primary or metastatic tumors during an intermediate stage of metastasis....

    Authors: Xiaoming Zhong, Hangtian Zhang, Ying Zhu, Yuqing Liang, Zhuolin Yuan, Jiachen Li, Jing Li, Xin Li, Yifan Jia, Tian He, Jiangyuan Zhu, Yu Sun, Wengting Jiang, Hui Zhang, Cheng Wang and Zunfu Ke

    Citation: Molecular Cancer 2020 19:15

    Content type: Review

    Published on:

  27. The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer-related diseases through crosstalk with tumour cells. Circ...

    Authors: Qiuge Zhang, Weiwei Wang, Quanbo Zhou, Chen Chen, Weitang Yuan, Jinbo Liu, Xiaoli Li and Zhenqiang Sun

    Citation: Molecular Cancer 2020 19:14

    Content type: Review

    Published on:

  28. As a novel class of noncoding RNAs, circRNAs have been recently identified to regulate tumorigenesis and aggressiveness. However, the function of circRNAs in colorectal cancer (CRC) metastasis remains unclear....

    Authors: Hongbao Yang, Xiaobo Li, Qingtao Meng, Hao Sun, Shenshen Wu, Weiwei Hu, Guilai Liu, Xianjing Li, Yong Yang and Rui Chen

    Citation: Molecular Cancer 2020 19:13

    Content type: Research

    Published on:

  29. Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains contr...

    Authors: Xiaohua Li, Shikun He and Binyun Ma

    Citation: Molecular Cancer 2020 19:12

    Content type: Review

    Published on:

  30. Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet to be elucidated. We aimed to identify lncRNAs that upregulated under hypoxia and their effects on colorectal cancer...

    Authors: Lin Huan, Tianan Guo, Yangjun Wu, Linguo Xu, Shenglin Huang, Ye Xu, Linhui Liang and Xianghuo He

    Citation: Molecular Cancer 2020 19:11

    Content type: Research

    Published on:

  31. PI3K/AKT is a vital signaling pathway in humans. Recently, several PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance (MDR); however, specific targets in the PI3K/AKT ...

    Authors: Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang and Zhe-Sheng Chen

    Citation: Molecular Cancer 2020 19:10

    Content type: Research

    Published on:

  32. MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signalin...

    Authors: Jinchang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, Xiaodong Zhao, Hui Tian, Jinxian He, Weiyu Shen, Xiaodan Meng, Xiaofeng Jin and Zhaohui Gong

    Citation: Molecular Cancer 2020 19:9

    Content type: Research

    Published on:

  33. Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted circRNAs as critical regulators of various tumours. More ...

    Authors: Zhonghua Ma, You Shuai, Xiangyu Gao, Xianzi Wen and Jiafu Ji

    Citation: Molecular Cancer 2020 19:8

    Content type: Review

    Published on:

  34. Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to t...

    Authors: Sandra Muñoz-Galván, Blanca Felipe-Abrio, Eva M. Verdugo-Sivianes, Marco Perez, Manuel P. Jiménez-García, Elisa Suarez-Martinez, Purificacion Estevez-Garcia and Amancio Carnero

    Citation: Molecular Cancer 2020 19:7

    Content type: Research

    Published on:

  35. Gastric cancer (GC) is the third leading cause of cancer-related mortality globally. Long noncoding RNAs (lncRNAs) are dysregulated in obvious malignancies including GC and exploring the regulatory mechanisms ...

    Authors: You Shuai, Zhonghua Ma, Weitao Liu, Tao Yu, Changsheng Yan, Hua Jiang, Shengwang Tian, Tongpeng Xu and Yongqian Shu

    Citation: Molecular Cancer 2020 19:6

    Content type: Research

    Published on:

  36. Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains large...

    Authors: Hailong Ma, Hanyue Chang, Wenyi Yang, Yusheng Lu, Jingzhou Hu and Shufang Jin

    Citation: Molecular Cancer 2020 19:4

    Content type: Research

    Published on:

  37. Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N6-methyladenosine (m6A) RNA mod...

    Authors: Bo Tang, Yihua Yang, Min Kang, Yunshan Wang, Yan Wang, Yin Bi, Songqing He and Fumio Shimamoto

    Citation: Molecular Cancer 2020 19:3

    Content type: Research

    Published on:

  38. The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis...

    Authors: Yizuo Song, Yichi Xu, Chunyu Pan, Linzhi Yan, Zhi-wei Wang and Xueqiong Zhu

    Citation: Molecular Cancer 2020 19:2

    Content type: Review

    Published on:

  39. Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC. ...

    Authors: Xin Li, Chuanyun Li, Liping Zhang, Min Wu, Ke Cao, Feifei Jiang, Dexi Chen, Ning Li and Weihua Li

    Citation: Molecular Cancer 2020 19:1

    Content type: Review

    Published on:

  40. N6-Methyladenosine (m6A) modification has been implicated in many biological processes. It is important for the regulation of messenger RNA (mRNA) stability, splicing, and translation. However, its role in cancer...

    Authors: Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun and Qiuhui Pan

    Citation: Molecular Cancer 2019 18:188

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Cancer 2020 19:24

  41. The majority of breast cancer patients die of metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly understood. Long noncoding RNAs (lncRNA) hav...

    Authors: Bingqiu Xiu, Yayun Chi, Lei Liu, Weiru Chi, Qi Zhang, Jiajian Chen, Rong Guo, Jing Si, Lun Li, Jingyan Xue, Zhi-Ming Shao, Zhao-Hui Wu, Shenglin Huang and Jiong Wu

    Citation: Molecular Cancer 2019 18:187

    Content type: Research

    Published on:

  42. N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. As the largest known component in the m6A methyltransfer...

    Authors: Tian Lan, Hui Li, Delin Zhang, Lin Xu, Hailing Liu, Xiangyong Hao, Xiaokai Yan, Haotian Liao, Xiangzheng Chen, Kunlin Xie, Jiaxin Li, Mingheng Liao, Jiwei Huang, Kefei Yuan, Yong Zeng and Hong Wu

    Citation: Molecular Cancer 2019 18:186

    Content type: Research

    Published on:

  43. Colon cancer (CC) cells can exhibit stemness and expansion capabilities, which contribute to resistance to conventional chemotherapies. Aberrant expression of CBX8 has been identified in many types of cancer, ...

    Authors: Yi Zhang, Min Kang, Bin Zhang, Fanchao Meng, Jun Song, Hiroshi Kaneko, Fumio Shimamoto and Bo Tang

    Citation: Molecular Cancer 2019 18:185

    Content type: Research

    Published on:

  44. Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. Surgical resection and adjuvant therapy have limited effects on th...

    Authors: Xiaomeng Liu, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu and Si Shi

    Citation: Molecular Cancer 2019 18:184

    Content type: Review

    Published on:

  45. Chemotherapy is a widely used treatment for cancer. However, the development of acquired multidrug resistance (MDR) is a serious issue. Emerging evidence has shown that the extracellular vesicles (EVs) mediate...

    Authors: Xiaokun Wang, Dongjuan Qiao, Likun Chen, Meng Xu, Shupeng Chen, Liyan Huang, Fang Wang, Zhen Chen, Jiye Cai and Liwu Fu

    Citation: Molecular Cancer 2019 18:182

    Content type: Research

    Published on:

Annual Journal Metrics