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  1. Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyros...

    Authors: Lirong Peng, Xiaofang Xing, Weijun Li, Like Qu, Lin Meng, Shenyi Lian, Beihai Jiang, Jian Wu and Chengchao Shou
    Citation: Molecular Cancer 2009 8:110
  2. Doxorubicin is one of the few chemotherapeutic drugs able to exert both cytotoxic and pro-immunogenic effects against cancer cells. Following the drug administration, the intracellular protein calreticulin is ...

    Authors: Sara De Boo, Joanna Kopecka, Davide Brusa, Elena Gazzano, Lina Matera, Dario Ghigo, Amalia Bosia and Chiara Riganti
    Citation: Molecular Cancer 2009 8:108
  3. Therapeutic strategies exist for human pulmonary neoplasia, however due to the heterogeneity of the disease, most are not very effective. The innate immunity gene, toll-like receptor 4 (TLR4), protects against...

    Authors: Alison K Bauer, Jennifer Fostel, Laura M Degraff, Elizabeth A Rondini, Christopher Walker, Sherry F Grissom, Julie Foley and Steven R Kleeberger
    Citation: Molecular Cancer 2009 8:107
  4. Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models. More directl...

    Authors: Aaron E Foster, Fatma V Okur, Ettore Biagi, An Lu, Gianpietro Dotti, Eric Yvon, Barbara Savoldo, George Carrum, Michael Andreeff, Margaret A Goodell, Helen E Heslop and Malcolm K Brenner
    Citation: Molecular Cancer 2009 8:106
  5. With the aim to simplify cancer management, cancer research lately dedicated itself more and more to discover and develop non-invasive biomarkers. In this connection, circulating cell-free DNA (ccf DNA) seems ...

    Authors: Corina Kohler, Ramin Radpour, Zeinab Barekati, Reza Asadollahi, Johannes Bitzer, Edward Wight, Nicole Bürki, Claude Diesch, Wolfgang Holzgreve and Xiao Yan Zhong
    Citation: Molecular Cancer 2009 8:105
  6. Hypoxia inducible factor-1 alpha (HIF-1α) protein is rapidly degraded under normoxic conditions. When oxygen tensions fall HIF-1α protein stabilizes and transactivates genes involved in adaptation to hypoxic c...

    Authors: Caroline N Mills, Sandeep S Joshi and Richard M Niles
    Citation: Molecular Cancer 2009 8:104
  7. p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function and exertion of dominant-negative effects over the remaining wild-type protein, se...

    Authors: Peixin Dong, Zhujie Xu, Nan Jia, Dajin Li and Youji Feng
    Citation: Molecular Cancer 2009 8:103
  8. An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...

    Authors: Therese Bredholt, Elizabeth AO Dimba, Hanne R Hagland, Line Wergeland, Jørn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr and Bjørn T Gjertsen
    Citation: Molecular Cancer 2009 8:101
  9. The chemopreventive effects of dietary phytochemicals on malignant tumors have been studied extensively because of a relative lack of toxicity. To achieve desirable effects, however, treatment with a single ag...

    Authors: Yoshitaka Nakamura, Shingo Yogosawa, Yasuyuki Izutani, Hirotsuna Watanabe, Eigo Otsuji and Tosiyuki Sakai
    Citation: Molecular Cancer 2009 8:100
  10. Imatinib mesylate has significantly improved survival and quality of life of patients with gastrointestinal stromal tumors (GISTs). However, the molecular mechanism through which imatinib exerts its anti-tumor...

    Authors: Jheri J Dupart, Jonathan C Trent, Ho-Young Lee, Kenneth R Hess, Andrew K Godwin, Takahiro Taguchi and Wei Zhang
    Citation: Molecular Cancer 2009 8:99
  11. PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (P...

    Authors: Catherine Fan, Lizhi He, Anil Kapoor, Adrian P Rybak, Jason De Melo, Jean-Claude Cutz and Damu Tang
    Citation: Molecular Cancer 2009 8:98
  12. Based on its role in angiogenesis and apoptosis, the inhibition of NFκB activity is considered an effective treatment for cancer, hampered by the lack of selective and safe inhibitors. We recently demonstrated...

    Authors: Daniela Sorriento, Alfonso Campanile, Gaetano Santulli, Eleonora Leggiero, Lucio Pastore, Bruno Trimarco and Guido Iaccarino
    Citation: Molecular Cancer 2009 8:97
  13. A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer. It has been suggested that the mechanism of this associatio...

    Authors: Ludmila Prokunina-Olsson and Jennifer L Hall
    Citation: Molecular Cancer 2009 8:96
  14. The mitotic Aurora-A kinase exerts crucial functions in maintaining mitotic fidelity. As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by whic...

    Authors: Jin-e Yao, Min Yan, Zhong Guan, Chao-bin Pan, Liang-ping Xia, Chuan-xing Li, Li-hui Wang, Zi-jie Long, Yan Zhao, Ming-wei Li, Fei-meng Zheng, Jie Xu, Dong-jun Lin and Quentin Liu
    Citation: Molecular Cancer 2009 8:95
  15. Photodynamic therapy (PDT) is a promising cancer treatment modality that involves the interaction of the photosensitizer, molecular oxygen and light of specific wavelength to destroy tumor cells. Treatment ind...

    Authors: Ramaswamy Bhuvaneswari, Yik Yuen Gan, Khee Chee Soo and Malini Olivo
    Citation: Molecular Cancer 2009 8:94
  16. Lung cancer remains a leading cause of cancer death among both men and women in the United States. Treatment modalities available for this malignancy are inadequate and thus new drugs with improved pharmacolog...

    Authors: Prasanthi Karna, Starlette M Sharp, Clayton Yates, Satya Prakash and Ritu Aneja
    Citation: Molecular Cancer 2009 8:93
  17. Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iEκ) and the kappa 3' enhancer (3'Eκ). The active enhancers and expression of immunoglobulin...

    Authors: HaiDan Liu, Hui Zheng, Zhi Duan, DuoSha Hu, Ming Li, SuFang Liu, ZiJian Li, XiYun Deng, ZhenLian Wang, Min Tang, Ying Shi, Wei Yi and Ya Cao
    Citation: Molecular Cancer 2009 8:92
  18. FUS1/TUSC2 is a novel tumor suppressor located in the critical 3p21.3 chromosomal region frequently deleted in multiple cancers. We previously showed that Tusc2-deficient mice display a complex immuno-inflamma...

    Authors: Alla V Ivanova, Sergey V Ivanov, Ljudmila Prudkin, Daisuke Nonaka, Zhandong Liu, Anne Tsao, Ignacio Wistuba, Jack Roth and Harvey I Pass
    Citation: Molecular Cancer 2009 8:91
  19. β-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low h...

    Authors: Haluk Yuzugullu, Khemais Benhaj, Nuri Ozturk, Serif Senturk, Emine Celik, Asli Toylu, Nilgun Tasdemir, Mustafa Yilmaz, Esra Erdal, Kamil Can Akcali, Nese Atabey and Mehmet Ozturk
    Citation: Molecular Cancer 2009 8:90
  20. Remodelling of mitochondrial metabolism is a hallmark of cancer. Mutations in the genes encoding succinate dehydrogenase (SDH), a key Krebs cycle component, are associated with hereditary predisposition to phe...

    Authors: Ana M Cervera, Jean-Pierre Bayley, Peter Devilee and Kenneth J McCreath
    Citation: Molecular Cancer 2009 8:89
  21. Generation of plasmin is a characteristic of tumor cells, promoting the degradation of extracellular matrix, tumor progression and metastasis. The process is accelerated if plasminogen and plasminogen activato...

    Authors: Nataša Obermajer, Bojan Doljak and Janko Kos
    Citation: Molecular Cancer 2009 8:88
  22. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that is particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen for HCC treatment. How...

    Authors: Ratna Kumari, Aanchal Sharma, Amrendra Kumar Ajay and Manoj Kumar Bhat
    Citation: Molecular Cancer 2009 8:87
  23. Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis. Animal...

    Authors: Sonja Röhrs, Wilhelm G Dirks, Claus Meyer, Rolf Marschalek, Michaela Scherr, Robert Slany, Andrew Wallace, Hans G Drexler and Hilmar Quentmeier
    Citation: Molecular Cancer 2009 8:86
  24. Activation of p53-mediated gene transcription is a critical cellular response to DNA damage and involves a phosphorylation-acetylation cascade of p53. The discovery of differences in the response to different ...

    Authors: Rosa Puca, Lavinia Nardinocchi, Ada Sacchi, Gideon Rechavi, David Givol and Gabriella D'Orazi
    Citation: Molecular Cancer 2009 8:85
  25. Little is known about the molecules that contribute to tumor progression of epithelial ovarian cancer (EOC), currently a leading cause of mortality from gynecological malignancies. Glucocorticoid-Induced Leuci...

    Authors: Nassima Redjimi, Françoise Gaudin, Cyril Touboul, Dominique Emilie, Marc Pallardy, Armelle Biola-Vidamment, Hervé Fernandez, Sophie Prévot, Karl Balabanian and Véronique Machelon
    Citation: Molecular Cancer 2009 8:83
  26. Mutation detection in clinical tumour samples is challenging when the proportion of tumour cells, and thus mutant alleles, is low. The limited sensitivity of conventional sequencing necessitates the adoption o...

    Authors: Hongdo Do and Alexander Dobrovic
    Citation: Molecular Cancer 2009 8:82
  27. Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammatio...

    Authors: Shan Wang, Qian Liu, Ying Zhang, Ke Liu, Pengfei Yu, Kun Liu, Jinling Luan, Huiying Duan, Zhaoqiao Lu, Fengfei Wang, Erxi Wu, Kazumi Yagasaki and Guoying Zhang
    Citation: Molecular Cancer 2009 8:81
  28. Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.

    Authors: Martin Michaelis, Denise Klassert, Susanne Barth, Tatyana Suhan, Rainer Breitling, Bernd Mayer, Nora Hinsch, Hans W Doerr, Jaroslav Cinatl and Jindrich Cinatl jr
    Citation: Molecular Cancer 2009 8:80
  29. Thyroid carcinoma is the most common endocrine malignancy and a common cancer among the malignancies of head and neck. Noninvasive and convenient biomarkers for diagnosis of papillary thyroid carcinoma (PTC) a...

    Authors: Yuxia Fan, Linan Shi, Qiuliang Liu, Rui Dong, Qian Zhang, Shaobo Yang, Yingzhong Fan, Heying Yang, Peng Wu, Jiekai Yu, Shu Zheng, Fuquan Yang and Jiaxiang Wang
    Citation: Molecular Cancer 2009 8:79
  30. Tumour stromal myofibroblasts can promote tumour invasion. As these cells are genetically more stable than cancer cells, there has been enormous interest in developing targeted molecular therapies against them...

    Authors: Qin Yao, Xun Qu, Qifeng Yang, David A Good, Shuzhen Dai, Beihua Kong and Ming Q Wei
    Citation: Molecular Cancer 2009 8:78

    The Retraction Note to this article has been published in Molecular Cancer 2009 8:84

  31. Colon cancer-associated MS4A12 is a novel colon-specific component of store-operated Ca2+ (SOC) entry sensitizing cells for epidermal growth factor (EGF)-mediated effects on proliferation and chemotaxis. In the p...

    Authors: Michael Koslowski, Özlem Türeci, Christoph Huber and Ugur Sahin
    Citation: Molecular Cancer 2009 8:77
  32. Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast c...

    Authors: Argun Akcakanat, Li Zhang, Spiridon Tsavachidis and Funda Meric-Bernstam
    Citation: Molecular Cancer 2009 8:75
  33. Recent epidemiological studies have suggested that obesity is associated with ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor development by enhancing cell growth and surviva...

    Authors: Shahab Uddin, Rong Bu, Maqbool Ahmed, Jehad Abubaker, Fouad Al-Dayel, Prashant Bavi and Khawla S Al-Kuraya
    Citation: Molecular Cancer 2009 8:74
  34. Gene expression profiling of spontaneous tumors in the dog offers a unique translational opportunity to identify prognostic biomarkers and signaling pathways that are common to both canine and human. Osteosarc...

    Authors: Gayathri T Selvarajah, Jolle Kirpensteijn, Monique E van Wolferen, Nagesha AS Rao, Hille Fieten and Jan A Mol
    Citation: Molecular Cancer 2009 8:72
  35. Programmed cell death 4 (Pdcd4) is a novel tumour suppressor and originally identified as a neoplastic transformation inhibitor. The aim of this study was to investigate the expression, prognostic significance...

    Authors: Na Wei, Stephanie S Liu, Thomas HY Leung, Kar F Tam, Xiao Y Liao, Annie NY Cheung, Karen KL Chan and Hextan YS Ngan
    Citation: Molecular Cancer 2009 8:70
  36. The development of Imatinib Mesylate (IM), the first specific inhibitor of BCR-ABL1, has had a major impact in patients with Chronic Myeloid Leukemia (CML), establishing IM as the standard therapy for CML. Des...

    Authors: Edurne San José-Enériz, José Román-Gómez, Antonio Jiménez-Velasco, Leire Garate, Vanesa Martin, Lucia Cordeu, Amaia Vilas-Zornoza, Paula Rodríguez-Otero, María José Calasanz, Felipe Prósper and Xabier Agirre
    Citation: Molecular Cancer 2009 8:69
  37. Hormone-refractory prostate cancer (HRPC) is characterized by poor response to chemotherapy and high mortality, particularly among African American men when compared to other racial/ethnic groups. It is genera...

    Authors: Melanie Mediavilla-Varela, Fabio J Pacheco, Frankis Almaguel, Jossymar Perez, Eva Sahakian, Tracy R Daniels, Lai Sum Leoh, Amelia Padilla, Nathan R Wall, Michael B Lilly, Marino De Leon and Carlos A Casiano
    Citation: Molecular Cancer 2009 8:68
  38. Signal Transducer and Activator of Transcription 5 A and B (STAT5) are key survival factors in cells of the lymphoid lineage. Identification of novel, tissue-specific STAT5 regulated genes would advance the ab...

    Authors: Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui and Robert A Kirken
    Citation: Molecular Cancer 2009 8:67
  39. Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear. Mutational inactivation of the tumour suppressor p...

    Authors: Khong Bee Kang, Congju Zhu, Sook Kwin Yong, Qiuhan Gao and Meng Cheong Wong
    Citation: Molecular Cancer 2009 8:66
  40. Methionine aminopeptidase 2 (MetAP2) is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis. MetAP2 is overexpressed in human colon cancer...

    Authors: Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Umashankar Das, Hari N Pati, Jonathan R Dimmock and Rajendra K Sharma
    Citation: Molecular Cancer 2009 8:65
  41. Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germlin...

    Authors: Hidetaka Yamada, Kazuya Shinmura, Masanori Goto, Moriya Iwaizumi, Hiroyuki Konno, Hideki Kataoka, Masami Yamada, Takachika Ozawa, Toshihiro Tsuneyoshi, Fumihiko Tanioka and Haruhiko Sugimura
    Citation: Molecular Cancer 2009 8:63
  42. We have demonstrated that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). Chemotherapy is a power...

    Authors: Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto
    Citation: Molecular Cancer 2009 8:62
  43. Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of...

    Authors: Stephan Emmrich, Weiwei Wang, Katja John, Wenzhong Li and Brigitte M Pützer
    Citation: Molecular Cancer 2009 8:61
  44. Lats1 (large tumor suppressor 1) codes for a serine/threonine kinase that plays a role in the progression through mitosis. Genetic studies demonstrated that the loss of LATS1 in mouse, and of its ortholog wts (wa...

    Authors: Rania Siam, Ryoko Harada, Chantal Cadieux, Robert Battat, Charles Vadnais and Alain Nepveu
    Citation: Molecular Cancer 2009 8:60

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