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  1. Research

    KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

    Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during th...

    Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang and Haiyan Chu

    Molecular Cancer 2017 16:46

    Published on: 23 February 2017

  2. Review

    Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

    Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports h...

    Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Molecular Cancer 2017 16:42

    Published on: 17 February 2017

  3. Review

    Intra-tumor heterogeneity from a cancer stem cell perspective

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Pramudita R. Prasetyanti and Jan Paul Medema

    Molecular Cancer 2017 16:41

    Published on: 16 February 2017

  4. Research

    LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation

    Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early...

    Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang and Guozhong Ji

    Molecular Cancer 2017 16:39

    Published on: 16 February 2017

  5. Research

    Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

    We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increa...

    Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis and David N. Brindley

    Molecular Cancer 2017 16:36

    Published on: 8 February 2017

  6. Research

    CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer

    CD73 (ecto-5′-nucleotidase) is implicated in the development of many types of cancer. CD73 inhibitors are currently being tested in clinical trials for the treatment of cancer. Understanding the molecular and ...

    Jianjie Zhu, Yuanyuan Zeng, Wei Li, Hualong Qin, Zhe Lei, Dan Shen, Dongmei Gu, Jian-an Huang and Zeyi Liu

    Molecular Cancer 2017 16:34

    Published on: 3 February 2017

  7. Research

    Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

    Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linke...

    Rehan Ahmad, Maroof Alam, Masanori Hasegawa, Yasumitsu Uchida, Omar Al-Obaid, Surender Kharbanda and Donald Kufe

    Molecular Cancer 2017 16:33

    Published on: 2 February 2017

  8. Research

    Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

    More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen

    Molecular Cancer 2017 16:30

    Published on: 1 February 2017

  9. Review

    Epigenetics in cancer stem cells

    Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Molecular Cancer 2017 16:29

    Published on: 1 February 2017

  10. Review

    Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

    The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass

    Molecular Cancer 2017 16:28

    Published on: 1 February 2017

  11. Research

    Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

    ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska

    Molecular Cancer 2017 16:32

    Published on: 1 February 2017

  12. Review

    Mesenchymal stem cells: key players in cancer progression

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Molecular Cancer 2017 16:31

    Published on: 1 February 2017

  13. Short communication

    Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Molecular Cancer 2017 16:19

    Published on: 31 January 2017

  14. Review

    Circular RNAs in human cancer

    CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique st...

    Yumin Wang, Yongzhen Mo, Zhaojian Gong, Xiang Yang, Mo Yang, Shanshan Zhang, Fang Xiong, Bo Xiang, Ming Zhou, Qianjin Liao, Wenling Zhang, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Molecular Cancer 2017 16:25

    Published on: 31 January 2017

  15. Research

    Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ

    Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu

    Molecular Cancer 2017 16:20

    Published on: 31 January 2017

  16. Research

    Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

    Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita

    Molecular Cancer 2017 16:21

    Published on: 31 January 2017

  17. Research

    MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors

    Contemporary challenges of prostate cancer (PCa) include overdiagnosis and overtreatment, entailing the need for novel clinical tools to improve risk stratification and therapy selection. PCa diagnosis and pro...

    Jorge Torres-Ferreira, João Ramalho-Carvalho, Antonio Gomez, Francisco Duarte Menezes, Rui Freitas, Jorge Oliveira, Luís Antunes, Maria José Bento, Manel Esteller, Rui Henrique and Carmen Jerónimo

    Molecular Cancer 2017 16:26

    Published on: 31 January 2017

  18. Review

    The evolving concept of liver cancer stem cells

    Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Kouki Nio, Taro Yamashita and Shuichi Kaneko

    Molecular Cancer 2017 16:4

    Published on: 30 January 2017

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