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  1. Letter to the Editor

    Serum microRNA profiling in patients with glioblastoma: a survival analysis

    Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with out...

    Hua Zhao, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller and Amy B. Heimberger

    Molecular Cancer 2017 16:59

    Published on: 11 March 2017

  2. Review

    Circles reshaping the RNA world: from waste to treasure

    A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently clos...

    Jing Liu, Tian Liu, Xiaman Wang and Aili He

    Molecular Cancer 2017 16:58

    Published on: 9 March 2017

  3. Research

    Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

    Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular mar...

    Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed and Martin Götte

    Molecular Cancer 2017 16:57

    Published on: 7 March 2017

  4. Research

    MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

    Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor w...

    Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone and Fabiola Moretti

    Molecular Cancer 2017 16:55

    Published on: 7 March 2017

  5. Research

    BMI1, a new target of CK2α

    The polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in par...

    Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M. Moxley, Priyabrata Mukherjee and Resham Bhattacharya

    Molecular Cancer 2017 16:56

    Published on: 7 March 2017

  6. Review

    Ion channels or aquaporins as novel molecular targets in gastric cancer

    Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion ...

    Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang and Ming Zeng

    Molecular Cancer 2017 16:54

    Published on: 6 March 2017

  7. Research

    miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1

    Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of car...

    Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li…

    Molecular Cancer 2017 16:53

    Published on: 4 March 2017

  8. Research

    MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

    Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates th...

    Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song and Luhua Wang

    Molecular Cancer 2017 16:50

    Published on: 28 February 2017

  9. Review

    The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

    The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li

    Molecular Cancer 2017 16:52

    Published on: 28 February 2017

  10. Research

    Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

    Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang

    Molecular Cancer 2017 16:51

    Published on: 28 February 2017

  11. Letter to the Editor

    Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors

    Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are de...

    Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone and Giuseppe Gasparre

    Molecular Cancer 2017 16:47

    Published on: 27 February 2017

  12. Research

    MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

    Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinica...

    Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu

    Molecular Cancer 2017 16:48

    Published on: 27 February 2017

  13. Research

    Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

    Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported ...

    Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C. Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A. López-Martín and M. Teresa Agulló-Ortuño

    Molecular Cancer 2017 16:45

    Published on: 23 February 2017

  14. Research

    ITIH5 mediates epigenetic reprogramming of breast cancer cells

    Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…

    Molecular Cancer 2017 16:44

    Published on: 23 February 2017

  15. Research

    KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

    Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during th...

    Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang and Haiyan Chu

    Molecular Cancer 2017 16:46

    Published on: 23 February 2017

  16. Review

    Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

    Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports h...

    Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Molecular Cancer 2017 16:42

    Published on: 17 February 2017

  17. Review

    Intra-tumor heterogeneity from a cancer stem cell perspective

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Pramudita R. Prasetyanti and Jan Paul Medema

    Molecular Cancer 2017 16:41

    Published on: 16 February 2017

  18. Research

    LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation

    Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early...

    Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang and Guozhong Ji

    Molecular Cancer 2017 16:39

    Published on: 16 February 2017

  19. Research

    Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

    We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increa...

    Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis and David N. Brindley

    Molecular Cancer 2017 16:36

    Published on: 8 February 2017

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