Warburg O: On the origin of cancer cells. Science. 1956, 123: 309-314. 10.1126/science.123.3191.309
Article
CAS
PubMed
Google Scholar
Mazurek S, Eigenbrodt E: The tumor metabolome. Anticancer Res. 2003, 23 (2A): 1149-54.
CAS
PubMed
Google Scholar
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC: Pyruvate kinase M2 is a phospho tyrosine-binding protein. Nature. 2008, 452 (7184): 181-186. 10.1038/nature06667
Article
CAS
PubMed
Google Scholar
Christofk HR, Vander Heiden MG, Hanis MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumor growth. Nature. 2008, 452 (7184): 230-233. 10.1038/nature06734
Article
CAS
PubMed
Google Scholar
Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Cheng GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Cheng J: Tyrosine Phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal. 2009, 2 (97): l-8. ra73
Article
Google Scholar
Hommes FA, Everts RS: Particulate and free hexokinase in fetal rat liver. Biol Neonate. 1978, 33 (3-4): 193-200. 10.1159/000241072
Article
CAS
PubMed
Google Scholar
Arora KK, Fanciulli M, Pedersen PL: Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase. J Biol Chem. 1990, 265 (11): 6481-8.
CAS
PubMed
Google Scholar
Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V: In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J. 2004, 377 (Pt.2): 347-355.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dombrauckas JD, Santarsiero BD, Mesecar AD: Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry. 2005, 44 (27): 9417-29. 10.1021/bi0474923
Article
CAS
PubMed
Google Scholar
Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL: The allosteric regulation of pyruvate kinase by fructose-1, 6-bisphosphate. Structure. 1998, 6 (2): 195-210.
Article
CAS
PubMed
Google Scholar
Costello LC, Franklin RB: Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer. Prostate. 1998, 35 (4): 285-296. 10.1002/(SICI)1097-0045(19980601)35:4<285::AID-PROS8>3.0.CO;2-F
Article
CAS
PubMed
Google Scholar
Schlichtholz B, Turyn J, Goyke E, Biernacki M, Jaskiewicz K, Sledzinski Z, Swierczynski J: Enhanced citrate synthase activity in human pancreatic cancer. Pancreas. 2005, 30 (2): 99-l04. 10.1097/01.mpa.0000153326.69816.7d
Article
CAS
PubMed
Google Scholar
Zanatta A, Schuck PF, Viegas CM, Knebel LA, Busanello EN, Moura AP: In vitro evidence that D-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex. Brain Res. 2009, 1298: 186-193.
Article
CAS
PubMed
Google Scholar
Kimura Y, Kashima K, Daa T, Kondo Y, Yada K, Sasaki A: Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder:a new category of "neoplastic/non-morular" lesions. Virchows Arch. 2005, 446 (2): 194-199. 10.1007/s00428-004-1161-7
Article
CAS
PubMed
Google Scholar
Israël M, Schwartz L: Cancer a dysmethylation syndrome. 2005, Paris: John Libbey Eurotext
Google Scholar
Clarke B, Wyatt KM, McCormack JG: Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism. J Mol Cell Cardiol. 1996, 28 (2): 341-350. 10.1006/jmcc.1996.0032
Article
CAS
PubMed
Google Scholar
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007, 11: 37-51. 10.1016/j.ccr.2006.10.020
Article
CAS
PubMed
Google Scholar
Wheatley DN, Campbell E: Arginine deprivation, growth inhibition and tumor cell death: Deficient utilization of citrulline by malignant cells. Br J Cancer. 2003, 89 (3): 573-576. 10.1038/sj.bjc.6601134
Article
PubMed Central
CAS
PubMed
Google Scholar
Wheatley DN, Kilfeather , Stitt A, Campbell E: Integrity and stability of the citrulline-arginine pathway in normal and tumor cell lines. Cancer Lett. 2005, 227: 141-152. 10.1016/j.canlet.2005.01.004
Article
CAS
PubMed
Google Scholar
Feun L, You M, Wu CJ, Kuo MT, Wangpaichitr M, Spector S, Savaraj N: Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des. 2008, 14 (1): 1049-57. 10.2174/138161208784246199
Article
PubMed Central
CAS
PubMed
Google Scholar
Rous P: A sarcoma of the fowl transmissible by an agent separable from tumor cells. J Exp Med. 13: 397-411.
Stehelin D, Varmus HE, Bishop JM, Vogt PK: DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976, 260 (5547): 170-173. 10.1038/260170a0
Article
CAS
PubMed
Google Scholar
Newbeme PM: Choline deficiency associated with diethanolamine carcinogenicity. (Toxicological highlights). Toxicological sciences. 2002, 67: 1-3.
Article
Google Scholar
Lehman-McKeeman LD, Gamsky EA, Hicks SM, Vassalo JD, Mar M-H, Zeisel SH: Diethanolamine induces hepatic choline deficiency in mice. Toxicological sciences. 2002, 67: 38-45. 10.1093/toxsci/67.1.38
Article
CAS
PubMed
Google Scholar
Best CH, Huntsman ME: The effect of the components of lecithin upon deposition of fat in the liver. J Physiol. 1932, 75: 405-412.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vafai SB, Stock JB: Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. FEBS Lett. 2002, 518 (1-3): 1-4. 10.1016/S0014-5793(02)02702-3
Article
CAS
PubMed
Google Scholar
Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB: The PP2A-associated protein a4 is an essential inhibitor of apoptosis. Science. 2004, 306: 695-698. 10.1126/science.1100537
Article
CAS
PubMed
Google Scholar
Hacker HJ, Steinberg P, Bannasch P: Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/Dl-ethionine supplemented diet. Carcinogenesis. 1998, 19 (1): 99-107. 10.1093/carcin/19.1.99
Article
CAS
PubMed
Google Scholar
Ugi S, Imamura T, Ricketts W, Olefsky JM: Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation anddownstream mitogenic signaling. Mol Cell Biol. 2002, 22: 2375-87. 10.1128/MCB.22.7.2375-2387.2002
Article
PubMed Central
CAS
PubMed
Google Scholar
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J: Purification of porcine brain protein phosphatase 2A leucinecarboxyl methyltransferase and cloning of the human homologue. Biochemistry. 1999, 38: 16539-47. 10.1021/bi991646a
Article
CAS
PubMed
Google Scholar
Lee JA, Pallas DC: Leucine carboxyl methyltransferase-l is necessary for normal progression through mitosis in mammalian cells. J Biol Chem. 2007, 282 (42): 30974-84. Epub 2007 Aug 27. [PMID: 17724024], 10.1074/jbc.M704861200
Article
PubMed Central
CAS
PubMed
Google Scholar
Lee J, Chen Y, Tolstykh T, Stock J: A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci USA. 1996, 93 (12): 6043-7. 10.1073/pnas.93.12.6043
Article
PubMed Central
CAS
PubMed
Google Scholar
Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J: PME-I protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. Cancer Res. 2009, 69 (7): 2870-7. Epub 2009 Mar 17. [PMID: 19293187], 10.1158/0008-5472.CAN-08-2760
Article
PubMed Central
CAS
PubMed
Google Scholar
Longin S, Zwaenepoel K, Martens E, Louis W, Rondelet E, Goris J, Janssens V: Spatial control of protein phosphatase 2A (de)methylation. Exp Cell Res. 2008, 314 (l): 68-81. Epub2007 Aug 7. [PMID: 17803990]
Article
CAS
PubMed
Google Scholar
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y: Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 2008, 133 (1): 154-63. 10.1016/j.cell.2008.02.041
Article
CAS
PubMed
Google Scholar
Jordens J, Janssens V, Longin S, Stevens I, Martens E, Bultynck G, Engelborghs Y, Lescrinier E, Waelkens E, Goris J, Van Hoof C: The protein phosphatase 2A Phosphatase activator is a novel peptidyl-prolyl cis/transisomerase. Biol Chem. 2008, 281 (10): 6349-57. Epub Dec 27. [PMID: 16380337]
Article
Google Scholar
Turowski P, Fernandez A, Favre B, Lamb NJ, Hemmings BA: Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.A5. The journal of Cell Biology. 1995, 129: 397-410.
Article
CAS
PubMed
Google Scholar
Yan Z, Fedorov SA, Mumby MC, Williams RS: PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol. 2000, 20 (3): 1021-9. 10.1128/MCB.20.3.1021-1029.2000
Article
PubMed Central
CAS
PubMed
Google Scholar
Mazurek S, Zwerschke W, Jansen-Dûrr P, Eigenbrodt E: Effects of the human papilloma virus [IPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex. Biochem J. 2001, 356 (Pt l): 247-256.
Article
PubMed Central
CAS
PubMed
Google Scholar
Israël M: Four hidden metamorphoses: a remark on blood, muscle, mental diseases and cancer. 2004, Paris: John Libbey Eurotext
Google Scholar
Walker GE, Wilson EM, Powell D, Oh Y: Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells/molecular mechanism involves an Spl/Sp3 multiprotein complex. Endocrinology. 2001, 142 (9): 3817-27. 10.1210/en.142.9.3817
Article
CAS
PubMed
Google Scholar
Vedavathi M, Girish KS, Kumar MK: A novel low molecular weight alanine aminotansferase from fasted rat liver. Biochemistry (Moscow). 2006, 7l (Suppll): S105-S112.
Article
Google Scholar
Morino Y, Kojima H, Tanase S: Affinity labeling of alanine aminotransferase by 3-chloro-L-alanine. J Biol Chem. 1979, 254 (2): 279-285.
CAS
PubMed
Google Scholar
Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, Hullihen J, Pedersen PL: Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochemical Biophysical Res Commun. 2004, 324 (1): 269-275. 10.1016/j.bbrc.2004.09.047.
Article
CAS
Google Scholar
Tuszynski GP, Cossu G: Differential cytotoxic eflect of gossypol on human melanoma colon carcinoma and other tissue culture cell lines. Cancer Res. 1984, 44: 768-77l.
CAS
PubMed
Google Scholar
Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Zhu F, Ling Y, Griffith BN, Wang S, Yang D: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol. 2003, 66: 93-103. 10.1016/S0006-2952(03)00248-X
Article
CAS
PubMed
Google Scholar
Palanivel R, Velunthakal R, Kowluru A: Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin secreting INS-1 cells. Am J Physiol Endocrinol Metab. 2004, 286: E1032-1041. [PMID: 14970A091], 10.1152/ajpendo.00587.2003
Article
CAS
PubMed
Google Scholar
Don AS, Hogg PJ: Mitochondria as cancer drug targets. Trends in Molecular Medicine. 2004, 10: 372-378. 10.1016/j.molmed.2004.06.005
Article
CAS
PubMed
Google Scholar
Hamada Y, Nakamura J, Naruse K, Komori T, Kato K, Kasuya Y, Nagai R, Horiuchi S, Hotta N: Epalresta, an aldose reductase inhibitor, reduces the levels of Nepsilon-(carboxymethyl) Lysine protein adducts and their precursors in erythrocytesfromdiabetic patients. Diabetes Care. 2000, 23: 1539-44. 10.2337/diacare.23.10.1539
Article
CAS
PubMed
Google Scholar
O'Leary , Diaz E: Phosphoenol-3-bromopyruvate: A mechanism-based inhibitor of phospoenolpyruvate carboxylase from maize. J Bio Chem. 1982, 257 (24): 4603-05.
Google Scholar
Liu J, Peliska JA, O'Leary MH: Synthesis and study of (Z)-3-chlorophosphoenolpyruvate. Arch Biochem Biophy. 1990, 277 (l): 143-148.
Article
CAS
Google Scholar
Siess EA: Stimulation by 3-hydroxybutyrate of pyruvate carboxylation in mitochondria from rat liver. Eur J Biochem. 1985, 152 (l): 131-136.
Article
CAS
PubMed
Google Scholar
Guichard C, Pedruzzi E, Fay M, Marie JC, Braut-Boucher F, Daniel F, Grodet A, Gougerot-Pocidalo MA, Chastre E, Kotelevets L, Lizard G, Vandewalle A, Driss F, Ogier-Denis E: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human carcinoma. Carcinogenesis. 2006, 27 (9): l8l2-27.
Article
Google Scholar
Podesta FE, Plaxton WC: Activation of cytosolic pyruvate kinase by polyethylene glycol. Plant Physiol. 1993, 103: 285-288.
PubMed Central
CAS
PubMed
Google Scholar
Parnaud G, Tache S, Peiffer G, Corpet DE: Polyethylene-glycol suppresses colon cancer and causes dose-dependent regression of azoxymethane-induced aberrantcrypt foci in rats. Cancer Res. 1999, 59 (20): 5143-7.
CAS
PubMed
Google Scholar
Friedrich LV, Dougherty R: Fatal hypoglycemia associated with levofloxacin. Pharmacotherapy. 2004, 24 (12): 1807-12. 10.1592/phco.24.17.1807.52348
Article
PubMed
Google Scholar
Lionetti V, Linke A, Chandler MP, Young ME, Penn MS, Gupte S, d'Agostino C, Hintze TH, Stanley WC, Recchia FA: Carnitine palmitoyl transferase-l inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res. 2005, 66 (33): 423-461.
Google Scholar
Saxty BA, Novelli R, Dolle RE, Kruse LI, Reid DG, Camilleri P, Wells TN: Synthesis and evaluation of (+) and (-)-2, 2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase. Eur J Biochem. l99l, 202 (3): 889-896. 10.1111/j.1432-1033.1991.tb16448.x.
Article
Google Scholar
Casaschi A, Maiyoh GK, Rubio BK, Li RW, Adeli K, Theriault AG: The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells. J Nutr. 2004, 134: 1340-1346.
CAS
PubMed
Google Scholar
Choubey V, Maity P, Guha M, Kumar S, Srivastava K, Puri SK, Bandyopadhyay U: Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammoniumbromide: a possible antimalarial mechanism. Antimicrob Agents Chemother. 2007, 5l (2): 696-706.
Article
Google Scholar
Taylor MM, Macdonald K, Morris AJ, McMaster CR: Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction. FEBS J. 2005, 272 (19): 5056-63. 10.1111/j.1742-4658.2005.04914.x
Article
CAS
PubMed
Google Scholar
Driever PH, Knupfer MM, Cinatl J, Wolff JE: Valproic acid for the treatment of pediatric malignant glioma. Klin Padiatr. 1999, 2ll: 323-328.
Article
Google Scholar
Hijazi Y, Boulieu R: Contribution of CYP3A4, CYPZB6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metabolism and Disposition. 2002, 30: 853-858. 10.1124/dmd.30.7.853
Article
CAS
PubMed
Google Scholar
Lin HL, Kent UM, Hollenberg PF: The grapefruit juice effect is not limited to cytochrome P450(P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5. J Pharmacol Exp Ther. 2005, 313: 154-164.
Article
CAS
PubMed
Google Scholar
Goel A, Mathupala SP, Pedersen PL: Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. J Biol Chem. 2003, 278: 15333-40. 10.1074/jbc.M300608200
Article
CAS
PubMed
Google Scholar
Eliseeva ED, Valkov V, Jung M, Jung MO: Characterization of novel inhibitors of histone acetyltransferases. Mol Cancer Ther. 2007, 6: 2391-8. 10.1158/1535-7163.MCT-07-0159
Article
CAS
PubMed
Google Scholar
Gellerman JL, Anderson WH, Schlenk H: Synthesis of anacardic acids in seeds of Ginkgo Biloba. Biochim Biophys Acta. 1976, 16-21.
Google Scholar
Shukla S, Mishra A, Fu P, Maclenan GT, Resnick MI, Gupta S: Up-regulation of insulin-like growth factor binding protein -3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenografts in athymic nude mice. FASEB J. 2005, 14: 2042-4.
Google Scholar
Nickerson T, Pollak M: Bicalutamide (Casodex) - induced prostate regression involves increased expression of genes encoding insulin-like growth factor binding proteins. Urology. 1999, 54 (6): 1120-5. 10.1016/S0090-4295(99)00421-5
Article
CAS
PubMed
Google Scholar
Murray IA, Perdew GH: Omeprazole stimulates the induction of human insulin - like growth factor binding protein -1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008, 324 (3): 1102-10.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bowles TL, Kim R, Galante J, Parsons CM, Virudachalam S, Kung HJ, Bold RJ: Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. Int J Cancer. 2008, 123 (8): 1950-5. 10.1002/ijc.23723
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung IU, Gandour-Edwaeds R, Chuang FY, Bold RJ, Kung HJ: Arginine deiminase as a novel therapy for prostate cancer induces autophary and caspase-independent apoptosis. Cancer Res. 2009, 69: 700-708. 10.1158/0008-5472.CAN-08-3157
Article
PubMed Central
CAS
PubMed
Google Scholar
Feun L, Savaraj N: Pegylated argininedeiminase: a novel anticancer enzyme agent. Expert Opin Investig Drugs. 2006, 15 (7): 815-822. 10.1517/13543784.15.7.815
Article
PubMed Central
CAS
PubMed
Google Scholar
Thomasset N, Quash GA, Doré JF: The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines. FEBS Lett. 1982, 148 (1): 63-66. 10.1016/0014-5793(82)81243-X
Article
CAS
PubMed
Google Scholar
Chang CI, Liao JC, Kuo L: Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Cancer Res. 2001, 61 (3): 1100-6.
CAS
PubMed
Google Scholar
Jung C, Gonon AT, Sjöquist PO, Lundberg TO, Pernow J: Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 20l0, 5 (1): 147-154.
Article
Google Scholar
Casero RA, Marton LJ: Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev, Drug disc. 2007, 6: 373-390. 10.1038/nrd2243.
Article
CAS
Google Scholar
Watanabe T, Yamatodani A, Maeyama K, Wada H: Pharmacology of alphafluoro methylhistidine, a specific inhibitor of histidine decarboxylase. Trends Pharmacol Sci. 1990, 11 (9): 363-367. 10.1016/0165-6147(90)90181-7
Article
CAS
PubMed
Google Scholar
Milovic V, Stein J, Piiper A, Gerhard R, Zeuzem S, Caspary WF: Characterization of putrescine transport across the intestinal epithelium: study using isolated brush border and basolateral membrane vesicles of the enterocyte. Eur J Clin Invest. 1995, 25 (2): 97-105. 10.1111/j.1365-2362.1995.tb01533.x
Article
CAS
PubMed
Google Scholar
Unterluggauer H, Mazurek S, Lener B, Hütter E, Eigenbrodt E, Zwerschke W, Jansen-Dürr P: Premature senescence of human endothelial cells induced by inhibition of glutaminase. Biogerontology. 2008, 9 (4): 247-259. 10.1007/s10522-008-9134-x
Article
CAS
PubMed
Google Scholar
Goodwin BL, Corbin KD, Pendleton LC, Levy MM, Solomonson LP, Eichler DC: Trogliazone up-regulates vascular endothelial argininosuccinate synthase. Biochem Biophys Res Commun. 2008, 370 (2): 254-258. 10.1016/j.bbrc.2008.03.089
Article
CAS
PubMed
Google Scholar
Gernez A: Le Cancer dynamique et eradication. 1969, 52: Roubaix: printed by Verschave
Google Scholar
Gernez A: Le Cancer, la carcinogénèse mécanisme et prévention. 1974, Editions de La Vie Claire
Google Scholar
Gernez A: Néo-Postulats Biologiques et Pathogéniques. 1975, Editions de La Vie Claire
Google Scholar
Giuliani C, Saji M, Bucci I, Fiore G, Liberatore M, Singer DS, Monaco F, Kohn LD, Napolitano G: Transcriptional regulation of major histocompatibility complex class 1 gene by insulin and IGF-1 in FRTL-5 thyroid cells. J Endocrinol. 2006, 189 (3): 605-615. 10.1677/joe.1.06486
Article
CAS
PubMed
Google Scholar
Rossi P, Lindgren JA, Kullman C, Jondal M: Products of the lipoxygenase pathway in human natural killer cell cytotoxicity. Cell Immunol. 1985, 93 (l): 1-8.
Article
CAS
PubMed
Google Scholar
Miller SC: Echinacea: a miracle herb against aging and cancer? Evidence in vivo mice. Evid Based Complement Alternat Med. 2005, 2 (3): 309-314. 10.1093/ecam/neh118
Article
PubMed Central
PubMed
Google Scholar
Schulte-Löbbert S, Holoubek G, Müller WE, Schubert-Zsilavecz M, Wurglics M: Comparison of the synaptosomal uptake of serotonin by St John's wort products. J Pharm Pharmacol. 2004, 56 (6): 813-818.
Article
PubMed
Google Scholar
Evans DL, Lynch KG, Benton T, Dubé B, Gettes DR, Tustin NB, Lai JP, Metzger D, Douglas SD: Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome. Biol Psychiatry. 2008, 63: 899-905. 10.1016/j.biopsych.2007.08.012
Article
PubMed Central
CAS
PubMed
Google Scholar
Brastianos HC, Vottero E, Patrick BO, Van Soest R, Matainaho T, Mauk AG, Andersen RJ: Exiguamine A, an indoleamine-2, 3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua. J Am Chem Soc. 2006, 128: 16046-7. 10.1021/ja067211+
Article
CAS
PubMed
Google Scholar
Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC: Inhibition of indoleamine2, 3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nature Medicine. 2005, 11 (3): 312-319. 10.1038/nm1196
Article
CAS
PubMed
Google Scholar
Liao CH, Sang S, Ho CT, Lin JK: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. J Cell Biochem. 2005, 96 (1): 155-169. 10.1002/jcb.20540
Article
CAS
PubMed
Google Scholar
Marcu MG, Jung YJ, Lee S, Chung EJ, Lee MJ, Trepel J, Neckers L: Curcumin is an inhibitor of p300 histone acetyltransferase. Med Chem. 2006, 2 (2): 169-174. 10.2174/157340606776056133
Article
CAS
PubMed
Google Scholar
Pollak M: Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008, 8: 915-928. 10.1038/nrc2536
Article
CAS
PubMed
Google Scholar
Sattler UG, Hirschhauser F, Mueller-Klieser WF: Manipulation of glycolysis in malignant tumors: fantasy or therapy?. Curr Med Chem. 2010, 17 (2): 96-108. 10.2174/092986710790112657
Article
CAS
PubMed
Google Scholar
Tennant DA, Duran RV, Gottlieb E: Targeting metabolic transformation for cancer therapy. Nat Rev Cancer. 2010, 10 (4): 267-277. 10.1038/nrc2817
Article
CAS
PubMed
Google Scholar
Tennant DA, Gottlieb E: HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. J Mol Med. 2010, 88 (8): 839-49. 10.1007/s00109-010-0627-0
Article
CAS
PubMed
Google Scholar
Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, Hullihen J, Pedersen PL: Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun. 2004, 324 (1): 269-275. 10.1016/j.bbrc.2004.09.047
Article
CAS
PubMed
Google Scholar
Zhang H, Varin E, Briand M, Allouche S, Heutte N, Schwartz L, Poulain L, Icard P: Novel therapyfor malignant pleural mesothelioma based on anti-energetic effect: an xperimental study using 3-Bromopyruvate on nude mice. Anticancer Res. 2009, 29 (4): 1443-8.
CAS
PubMed
Google Scholar
Schwartz L, Abolhassani M, Guais A, Sanders E, Steyaert JM, Campion F, Israel M: A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results. Oncology reports. 2010, 23: 1407-16.
Article
CAS
PubMed
Google Scholar
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montavalvo A, Ingles S, de Cabo R, Cohen P, Longo VD: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signalling, cancer, and diabetes in humans. Sci Transl Med. 2011, 3: 70ra13-
Article
PubMed Central
PubMed
Google Scholar