Figure 4From: Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatinEleven chemicals that inhibit the FA pathway synergized with cisplatin in the killing of ovarian cancer cells. Isobolograms at the LD50 level obtained in at least 3 independent experiments performed with FA pathway-deficient ovarian cancer cells (2008) and their FA pathway-proficient counterpart (2008 + FANCF) are presented (except of lactacystin, for which the result of only one experiment is shown, because of the high concentration required to achieve 50% killing). Average combination index (CI) is indicated in the upper right corner of each isobologram: a CI ≤ 0.90 indicates synergism. Results are summarized in Table 2Back to article page