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Figure 4 | Molecular Cancer

Figure 4

From: Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin

Figure 4

Eleven chemicals that inhibit the FA pathway synergized with cisplatin in the killing of ovarian cancer cells. Isobolograms at the LD50 level obtained in at least 3 independent experiments performed with FA pathway-deficient ovarian cancer cells (2008) and their FA pathway-proficient counterpart (2008 + FANCF) are presented (except of lactacystin, for which the result of only one experiment is shown, because of the high concentration required to achieve 50% killing). Average combination index (CI) is indicated in the upper right corner of each isobologram: a CI ≤ 0.90 indicates synergism. Results are summarized in Table 2

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