Figure 6
From: RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy
Schematic model for the mechanism of RPN2-mediated CD63/MDR1 glycosylation pathway in breast cancer cells. In breast cancer cells, high expression of RPN2 resulted in increased glycosylation of CD63/MDR1 and enhanced membrane localization of CD63/MDR1, which promoted cancer malignancy. In contrast, inhibition of RPN2 expression reduced glycosylation of CD63/MDR1 and decreased membrane localization, thereby attenuating cancer malignancy in breast cancer cells.