Figure 6
From: RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy
![Figure 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1476-4598-13-134/MediaObjects/12943_2014_Article_1349_Fig6_HTML.jpg)
Schematic model for the mechanism of RPN2-mediated CD63/MDR1 glycosylation pathway in breast cancer cells. In breast cancer cells, high expression of RPN2 resulted in increased glycosylation of CD63/MDR1 and enhanced membrane localization of CD63/MDR1, which promoted cancer malignancy. In contrast, inhibition of RPN2 expression reduced glycosylation of CD63/MDR1 and decreased membrane localization, thereby attenuating cancer malignancy in breast cancer cells.