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Figure 6 | Molecular Cancer

Figure 6

From: SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Figure 6

The SRF-independent/SAP-dependent genes represent a bad prognostic signature for breast cancer patients. Tumors in the 1881-sample breast cancer data set were stratified into three quantiles, low, intermediate and high, based on SRF-dependent/SAP-independent (A) or SRF-independent/SAP-dependent (B) gene expression. (A) Kaplan-Meier survival analysis using distant metastasis free survival (DMFS) as endpoint and 10-year censoring for all tumors (n = 1379; left panels), or in the subgroups of lymph node (LN)-negative (n = 1111; middle panels) and untreated tumors (n = 821; right panels) was performed using the GOBO bioinformatics tool, interrogating the group of SRF-dependent/SAP-independent target genes. P-value is calculated using log-rank test. (B) Kaplan-Meier survival analysis for tumors with expression of SRF-independent/SAP-dependent Mkl1 target genes was performed as in (A). Association with clinical outcome was assessed in the subgroups of ER-positive (n = 856; left panel), Grade 1 (n = 141, middle panel) and Grade 2 (n = 446; right panel) tumors in addition to all tumors and the subgroups used in (A). P-value is calculated using log-rank test.

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Molecular Cancer

ISSN: 1476-4598