Table 1 CK1 interaction partners and substrates
From: Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
Protein | Description | CK1 interaction partners | Known Phospho-rylation sites | Cellular process | Reference |
|---|---|---|---|---|---|
BCL10 | B-cell CLL/lymphoma 10 | α |  | Apoptosis | [8] |
BID | BH3 interacting domain death agonist | α, δ | T59, S64 (α, δ) | Apoptosis | [9] |
FADD | Fas (TNFRSF6)-associated via death domain | α | S194 (α) | Apoptosis | [10] |
E2F1 | E2F transcription factor 1 | α |  | Cell cycle | [11] |
Chk1 | Checkpoint kinase 1 | δ |  | Cell cycle | [12] |
DDX3 | DEAD box RNA helicase | ϵ |  | DNA repair | [13] |
SPRY2 | Sprouty1 | δ, ϵ |  | FGF-signaling | [14] |
GLI1-3 | GLI family zinc finger 1-3 | α, δ, ϵ, γ1, γ2, γ3 |  | Hedgehog signaling | [15] |
ANT2 | Adenine nucleotide translocase 2 | ϵ |  | Mitochondrial function | [16] |
MST1 | Mammalian sterile 20-like kinase 1 | ϵ |  | Hippo signaling | [17] |
NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | α |  | NFκB signaling | [18] |
P65 | NFκB subunit | γ1 | S536 | NFκB signaling | [19] |
MDM2 MDMX (MDM4) | Mouse double minute 2 or 4 homolog | α |  | p53 signaling | [20] |
TP53 | Tumor protein p53 | α, δ, ϵ, γ1, γ2, γ3 | S6, S9 (α); T18 (δ) | p53 signaling | [21] |
Foxo1 | Forkhead box O1 | δ, ϵ, γ1, γ2, γ3 | S322 (α, γ1), S325 (α) | PI3K/AKT signaling | [22] |
RAPGEF2 | Rap guanine nucleotide ex-change factor 2 | α | S1244, S1248 | Ras activation | [23] |
SMAD3 | SMAD family member 3 | γ2, ϵ |  | TGF-beta/Smad signaling | [24] |
APC | Adenomatous polyposis coli | α, δ, ϵ | all ϵ: S1279, S1392, S1504, S1505, S1507, S1510 | Wnt signaling | [25] |
AXIN1 AXIN2 | Axin 1 and 2 | α, δ, ϵ, γ1 |  | Wnt signaling | [4] |
CTNNB1 | Beta-catenin | α, δ, ϵ | S45 (α, δ) | Wnt signaling | [4] |
NFATC3 | Nuclear factor of activated T-cells | α | all α: T204, S207, T210, S211, S215 | Wnt signaling | [26] |
DVL1-3 | Dishevelled, dsh homolog 1-3 | δ, ϵ, γ1 |  | Wnt signaling | [4] |
CSNK1D | Casein kinase 1, delta | ϵ |  | Wnt signaling | [4] |
FZD1 FZD5 | Frizzled homolog 1 or 5 | γ1 |  | Wnt signaling | [27] |
GSK3A GSK3B | Glycogen synthase kinase 3 alpha or beta | γ1 |  | Wnt signaling | [28] |
WNT3A | Wingless-type MMTV integration site family, member 3A | γ1 |  | Wnt signaling | [29] |