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Table 1 CK1 interaction partners and substrates

From: Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

Protein Description CK1 interaction partners Known Phospho-rylation sites Cellular process Reference
BCL10 B-cell CLL/lymphoma 10 α   Apoptosis [8]
BID BH3 interacting domain death agonist α, δ T59, S64 (α, δ) Apoptosis [9]
FADD Fas (TNFRSF6)-associated via death domain α S194 (α) Apoptosis [10]
E2F1 E2F transcription factor 1 α   Cell cycle [11]
Chk1 Checkpoint kinase 1 δ   Cell cycle [12]
DDX3 DEAD box RNA helicase ϵ   DNA repair [13]
SPRY2 Sprouty1 δ, ϵ   FGF-signaling [14]
GLI1-3 GLI family zinc finger 1-3 α, δ, ϵ, γ1, γ2, γ3   Hedgehog signaling [15]
ANT2 Adenine nucleotide translocase 2 ϵ   Mitochondrial function [16]
MST1 Mammalian sterile 20-like kinase 1 ϵ   Hippo signaling [17]
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha α   NFκB signaling [18]
P65 NFκB subunit γ1 S536 NFκB signaling [19]
MDM2 MDMX (MDM4) Mouse double minute 2 or 4 homolog α   p53 signaling [20]
TP53 Tumor protein p53 α, δ, ϵ, γ1, γ2, γ3 S6, S9 (α); T18 (δ) p53 signaling [21]
Foxo1 Forkhead box O1 δ, ϵ, γ1, γ2, γ3 S322 (α, γ1), S325 (α) PI3K/AKT signaling [22]
RAPGEF2 Rap guanine nucleotide ex-change factor 2 α S1244, S1248 Ras activation [23]
SMAD3 SMAD family member 3 γ2, ϵ   TGF-beta/Smad signaling [24]
APC Adenomatous polyposis coli α, δ, ϵ all ϵ: S1279, S1392, S1504, S1505, S1507, S1510 Wnt signaling [25]
AXIN1 AXIN2 Axin 1 and 2 α, δ, ϵ, γ1   Wnt signaling [4]
CTNNB1 Beta-catenin α, δ, ϵ S45 (α, δ) Wnt signaling [4]
NFATC3 Nuclear factor of activated T-cells α all α: T204, S207, T210, S211, S215 Wnt signaling [26]
DVL1-3 Dishevelled, dsh homolog 1-3 δ, ϵ, γ1   Wnt signaling [4]
CSNK1D Casein kinase 1, delta ϵ   Wnt signaling [4]
FZD1 FZD5 Frizzled homolog 1 or 5 γ1   Wnt signaling [27]
GSK3A GSK3B Glycogen synthase kinase 3 alpha or beta γ1   Wnt signaling [28]
WNT3A Wingless-type MMTV integration site family, member 3A γ1   Wnt signaling [29]
  1. CK1 substrates are shown with known phosphorylation sites together with the involved cellular processes of the corresponding proteins. The following programs were used for determination of interaction or phosphorylation: http://string-db.org, http://hprd.org; http://regphos.mbc.nctu.edu.tw, http://www.phosphosite.org. Only proteins validated by biochemical assays are shown.