Table 1 Methylated genes in primary follicular lymphoma samples
From: Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review
Gene | # of Methylated Samples (%) | Method of analysis | Gene function | Reference |
|---|---|---|---|---|
Androgen receptor | 25/26 (96) | MSP | Ligand-dependent transcription factor | [11] |
SHP1 | 32/33 (97) | MSP | Inhibits intracellular effects of surface immunoglobulin binding in B lymphocytes | [14, 15] |
Death-associated protein kinase | 25/29 (86) | MSP | Involved in interferon-γ, tumor necrosis factor-α, and Fas-ligand induced apoptosis | [5, 21] |
p16 | 5/16 (31) | ERP | Cyclin dependent kinase inhibitor | [26, 27] |
p15 | 10/27 (37) | ERP | Cyclin dependent kinase inhibitor | [27, 35] |
p57 | 8/18 (44) | MSP | Cyclin dependent kinase inhibitor | [40] |
GSTP1 | 10/18 (56) | MSP | Detoxify mutagens | [5] |
IL-12 receptor β-2 | 2/2 (100) | MSP | Forms heterodimer with IL-12Rβ1 to form IL-12 receptor | [50] |
Snk/plk2 | 2/4 (50) | MSP | DNA damage response and cell growth arrest | [53] |
GADD45-γ | 1/6 (17) | MSP | DNA damage response and cell growth arrest | [56] |