KEGG pyrimidine metabolism diagram. Gene expression shifts are projected from comparisons of cell line-to-tumor (CL - T), cell line-to-normal (CL - N), and tumor-to-normal (T - N) comparisons averaged over all six tissues. The color red indicates upregulated genes, green indicates downregulated genes and grey indicates the genes that are not on the microarray. Uncolored genes are not in the organism-specific pathway for Homo sapiens. A gene is identified as upregulated (downregulated) if its gene expression value averaged over 6 tissue types were greater (or lesser) in cell lines compared to tumor or normal tissue. Colored genes with white lettering were also identified with SAM in at least two tissues.