Table 2 Differential expression of LASP-1 in various cell types and known regulators and modifiers of LASP-1-expression

bovine

breast epithelium

lactating mammary tissue

>18

cDNA-Microarray

[45]

mouse

prostatic adenocarcinma

Neu (erbB2)-overexpression

3.8

cRNA-Microarray

[71]

RAW264.7 macrophages

treatment with LPS

3.37

cDNA-Microarray

[72]

pluripotent mesenchymal C3H/10T1/2 cells

activation of Sonic Hedgehog signalling cascade

1.9

cDNA-Microarray

[53]

interstitial cells of Cajal

comparison to tunica muscularis

1.89

cDNA-Microarray

[73]

embryonic fibroblasts

overexpression of IGF-receptor

1.6

Northern Blots

[49]

FDB1 myeloic leukaemia cells

GM-CSF

1.5

QRT-PCR

[74]

human

chronic myeloid leukaemia K562 cells

stimulation of cells with haemin

8

cDNA-Microarray

[75]

BT-474 breast cancer cells

LASP1 gene amplification (8×)

≈ 8

Northern Blots

[2]

promyelocytic leukaemia HL60 cells

1'-25'-dihydroxy-cholecalciferole

4.97

cDNA-Microarray

[76]

podocytes

Wilms tumour suppressor 1 mutation

3.3

2D-DIGE

[28]

HEK293 cells

overexpression of HNF4α

2.8

cDNA-Microarray

[77]

30 different commercial and primary breast cancer cell lines

gain on 17q12

>2

cDNA-Microarray

[78]

E-cadherin mutation

Wnt activity

1.89

cDNA-Microarray

[47]

MDA-MB435S breast cancer cells

E-cadherin mutation

1.77

cDNA Microarray

[47]

MCF-7 breast cancer cells

Insulin like growth factor (IGF1)

1.6

cDNA-Microarray

[49]

porcine

primary retinal Müller glia cells

in vitro conditions

6.6

2D-Gel/Mass Spectrometry

[79]

rat

periaqueductal grey cells

reduced exploratory activity in the elevated plus maze

3.41

cDNA-RDA

[80]

phaeocytochromal PC12 cells

NGF induced SH2b1β-activity

3.3

cRNA-Microarray

[44]

alevolar macrophages CRL-2192

pseudohypoxia induced by bismuth

2.1

cDNA-Microarray

[81]

LASP-1 downregulation

species

cell type

stimulus

fold

technique

ref.

mouse

hindbrain

model for smith-lemli-opitz-syndrome

-3.24

cRNA-Microarray

[82]

mammary epithelium

Prolactin receptor knockout

-1.24

cDNA-Microarray

[83]

murine embryonic fibroblasts

oncogenic RAS expression in absence of p53

n.d.

cDNA-Microarray

[84]

human

chondrocytes

proinflammatory cytokine IL-1β

-2.3

cDNA-Microarray

[85]

mulitiple myeloma (MM)

transition from MGUS to MM

-1.91

cDNA-Microarray

[86]