Figure 7

Correlation analyses between LKB1 and LMO4 in pancreatic carcinogenesis. a, Correlation between LKB1 and LMO4 in primary cultured fibroblasts (spearman test, p = 0.037, top) and correlation between LKB1 and LMO4 in cultured cancer cell lines (spearman test, p = 0.39, bottom). b, Expression of LKB1 mRNA levels in microdissected normal ducts, PanIN-1B cells, and IDC cells (top). The bottom and the top edges of the box mark the lower bound and upper bound of the 95% Confidence Interval for the Mean, respectively. The center horizontal line is drawn at the sample mean. The center vertical lines drawn from the boxes extend to the minimum and the maximum. Correlation between LKB1 and LMO4 mRNA levels in non-malignant cells (including normal ducts and PanIN-1B cells, spearman test, p = 0.042, middle), and correlation between LKB1 and LMO4 mRNA levels in IDC cells (spearman test, p = 0.453, bottom). Expression of LMO4 mRNA was normalized to that of 18S rRNA.