Table 5 Genes coding for proangiogenic or antiangiogenic molecules displaying altered expression in LP-1 derivatives (|FC|>3).
From: Cyclin K and cyclin D1b are oncogenic in myeloma cells
Gene | Protein | LP-1D1b vs. cl1 | LP-1K vs. cl1 |
|---|---|---|---|
FGFR3 | Fibroblast growth factor receptor 3 | +5.08* | nm** |
TNFRSF10B | Tumor necrosis factor receptor superfamily member 10 B | +3.52 | nm |
GATA4 | GATA binding protein 4 | +2.15 | nm |
WARS | Tryptophanyl-tRNA synthase | +4.01 | nm |
IGFBP3 | Insulin-like growth factor binding protein 3 | nm | +26.42 |
EPAS1 | Endothelial PAS domain protein 1 | nm | +17.39 |
CXCL12 | CXC chemokine ligand 12 | nm | +17.26 |
SLIT3 | SLIT homolog 3 | nm | +13.44 |
CCL2 | Chemokine ligand 2 | nm | +10.09 |
CXCL16 | CXC chemokine ligand 16 | nm | +6.67 |
F11R | F11 receptor | nm | +5.56 |
RUNX1 | Runt-related transcription factor 1 | nm | +5.13 |
EGFL7 | EGF-like domain multiple 7 | nm | +4.68 |
CTGF | Connective tissue growth factor | nm | +4.60 |
TNFSF13 | Tumor necrosis factor superfamily member 13 | nm | +4.57 |
SERPINB6 | Serpin peptidase inhibitor clade B member 6 | nm | +4.53 |
PDGFB | Platelet-derived growth factor beta | nm | +3.99 |
CXCL3 | CXC chemokine ligand 3 | nm | +3.76 |
SERPINE2 | Serpin peptidase inhibitor clade E member 2 | nm | +3.40 |
SERPINB1 | Serpin peptidase inhibitor clade B member 1 | nm | +3.36 |
IL8 | Interleukin 8 | nm | +3.30 |
MMP13 | Matrix metallopeptidase 13 | nm | +3.12 |
IFNGR1 | Interferon gamma receptor 1 | nm | +3.06 |
HAND2 | Heart and neural crest derivatives | nm | -3.04 |
NRP2 | Neuropilin | nm | -3.25 |
PTPRF | Protein tyrosine phosphatase receptor type F | nm | -4.20 |
RUNX1T1 | Runt-related transcription factor 1 translocated to 1 | nm | -4.79 |
ADM | Adrenomedullin | nm | -6.66 |
ID1 | Inhibitor of DNA binding 1 | nm | -8.32 |
LAMA3 | Laminin alpha 3 | nm | +8.45 |
IFI16 | Interferon gamma-inducible protein 16 | nm | +4.96 |
JAG2 | Jagged 2 | nm | +4.77 |
ZFP36 | Zinc finger protein 36 | nm | +3.60 |
ZFP36L2 | Zinc finger protein 36 C3H type-like 2 | nm | +3.60 |
BMPR1A | Bone morphogenetic protein receptor type 1A | nm | -3.65 |
PTPRM | Protein tyrosine phosphatase receprot type M | +2.11 | +10.38 |
JDB2 | Jun dimerization protein 2 | +3.70 | +3.74 |
IGF2BP1 | Insulin-like growth factor 2 binding protein 1 | -2.52 | -5.70 |
COL9A1 | Collagen type IX alpha 1 | -3.41 | -4.87 |
COL24A1 | Collagen type XXIV alpha 1 | -2.42 | -4.07 |
DAPK1 | Death-associated protein kinase 1 | +2.48 | -3.06 |