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Table 2 Top 100 activated kinases and targeted drugs in myxoid liposarcoma cell lines and primary cultures.

From: Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

 

Intensity

Kinase

Number of hits

Description

Drugs

1

7965,340

CK2

9

Casein kinase 2, alpha 1

4,5,6,7-tetrabromobenzotriazole

2

5932,666

LCK

3

Lymphocyte-specific protein tyrosine kinase

dasatinib

3

5932,666

FYN

2

FYN oncogene related to SRC, FGR, YES

dasatinib

4

4716,473

CAMK2B

5

Calcium/calmodulin-dependent protein kinase II beta

 

5

3998,331

PRKACA

8

Protein kinase, cAMP-dependent, catalytic, alpha

 

6

3922,920

MAPK1

4

Mitogen-activated protein kinase 1 [

 

7

3922,920

KIT

1

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

dasatinib, sunitinib ao

8

3402,973

CSNK1A1

1

Casein kinase 1, alpha 1

 

9

3402,973

CIB

2

Calcium and integrin binding family

 

10

3317,951

GSK3

2

Glycogen synthase kinase 3

 

11

3144,082

LYN

1

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

 

12

3144,082

BTK

1

Bruton agammaglobulinemia tyrosine kinase

 

13

3114,907

PKC

19

Protein kinase C

 

14

3057,647

AKT1

3

V-akt murine thymoma viral oncogene homolog 1

enzastaurin

15

3033,443

PKM2

1

Pyruvate kinase, muscle

 

16

2928,117

CAMK1

1

Calcium/calmodulin-dependent protein kinase I

 

17

2893,922

CHEK1

1

CHK1 checkpoint homolog

 

18

2893,922

CHEK2

2

CHK2 checkpoint homolog

 

19

2893,922

PLK3

2

Polo-like kinase 3

 

20

2890,210

TTN

1

Titin

 

21

2712,053

ABL

2

Abelson murine leukemia viral (v-abl) oncogene homolog

imatinib, temozolomide

22

2596,825

INSR

1

Insulin receptor

lispro, aspart, glargine

23

2596,825

EGFR

2

Epidermal growth factor receptor

cetuximab, canertinib ao

24

2596,825

MET

1

Met proto-oncogene

 

25

2483,173

SRC

6

V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

 

26

2443,714

RPS6

4

Ribosomal protein S6

 

27

2382,003

CK

1

Choline kinase

 

28

2314,823

MAP2K3

1

Mitogen-activated protein kinase kinase 3

 

29

2294,228

GRK1

2

G protein-coupled receptor kinase 1

 

31

2216,637

JAK1

1

Janus kinase 1

 

32

2214,443

MAPKAPK2

1

Mitogen-activated protein kinase-activated protein kinase 2

 

33

2179,345

ALK

1

Anaplastic lymphoma receptor tyrosine kinase

 

34

2052,700

ATM

2

Ataxia telangiectasia mutated

 

35

2040,371

PKN1

2

Protein kinase N1

 

36

1913,813

PDGFRB

1

Platelet-derived growth factor receptor, beta polypeptide

dasatinib, sunitib ao

37

1870,956

CDK2

1

Cyclin-dependent kinase 2

BMS-387032, flavopiridol

38

1849,628

CCRK

1

Cell cycle related kinase

 

39

1806,824

CDC2

1

Cell division cycle 2, G1 to S and G2 to M

flavopiridol

  1. Top list of kinases was based on the intensity of incorporated radioactively labeled phosphorus, corresponding with kinase activity. The number of hits corresponds to the number of substrates to be phosphorylated by a specific kinase, not necessarily associated with kinase activity as substrates were not equally covered by the different kinases.
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Molecular Cancer

ISSN: 1476-4598