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Table 2 Top 100 activated kinases and targeted drugs in myxoid liposarcoma cell lines and primary cultures.

From: Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

  Intensity Kinase Number of hits Description Drugs
1 7965,340 CK2 9 Casein kinase 2, alpha 1 4,5,6,7-tetrabromobenzotriazole
2 5932,666 LCK 3 Lymphocyte-specific protein tyrosine kinase dasatinib
3 5932,666 FYN 2 FYN oncogene related to SRC, FGR, YES dasatinib
4 4716,473 CAMK2B 5 Calcium/calmodulin-dependent protein kinase II beta  
5 3998,331 PRKACA 8 Protein kinase, cAMP-dependent, catalytic, alpha  
6 3922,920 MAPK1 4 Mitogen-activated protein kinase 1 [  
7 3922,920 KIT 1 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog dasatinib, sunitinib ao
8 3402,973 CSNK1A1 1 Casein kinase 1, alpha 1  
9 3402,973 CIB 2 Calcium and integrin binding family  
10 3317,951 GSK3 2 Glycogen synthase kinase 3  
11 3144,082 LYN 1 V-yes-1 Yamaguchi sarcoma viral related oncogene homolog  
12 3144,082 BTK 1 Bruton agammaglobulinemia tyrosine kinase  
13 3114,907 PKC 19 Protein kinase C  
14 3057,647 AKT1 3 V-akt murine thymoma viral oncogene homolog 1 enzastaurin
15 3033,443 PKM2 1 Pyruvate kinase, muscle  
16 2928,117 CAMK1 1 Calcium/calmodulin-dependent protein kinase I  
17 2893,922 CHEK1 1 CHK1 checkpoint homolog  
18 2893,922 CHEK2 2 CHK2 checkpoint homolog  
19 2893,922 PLK3 2 Polo-like kinase 3  
20 2890,210 TTN 1 Titin  
21 2712,053 ABL 2 Abelson murine leukemia viral (v-abl) oncogene homolog imatinib, temozolomide
22 2596,825 INSR 1 Insulin receptor lispro, aspart, glargine
23 2596,825 EGFR 2 Epidermal growth factor receptor cetuximab, canertinib ao
24 2596,825 MET 1 Met proto-oncogene  
25 2483,173 SRC 6 V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog  
26 2443,714 RPS6 4 Ribosomal protein S6  
27 2382,003 CK 1 Choline kinase  
28 2314,823 MAP2K3 1 Mitogen-activated protein kinase kinase 3  
29 2294,228 GRK1 2 G protein-coupled receptor kinase 1  
31 2216,637 JAK1 1 Janus kinase 1  
32 2214,443 MAPKAPK2 1 Mitogen-activated protein kinase-activated protein kinase 2  
33 2179,345 ALK 1 Anaplastic lymphoma receptor tyrosine kinase  
34 2052,700 ATM 2 Ataxia telangiectasia mutated  
35 2040,371 PKN1 2 Protein kinase N1  
36 1913,813 PDGFRB 1 Platelet-derived growth factor receptor, beta polypeptide dasatinib, sunitib ao
37 1870,956 CDK2 1 Cyclin-dependent kinase 2 BMS-387032, flavopiridol
38 1849,628 CCRK 1 Cell cycle related kinase  
39 1806,824 CDC2 1 Cell division cycle 2, G1 to S and G2 to M flavopiridol
  1. Top list of kinases was based on the intensity of incorporated radioactively labeled phosphorus, corresponding with kinase activity. The number of hits corresponds to the number of substrates to be phosphorylated by a specific kinase, not necessarily associated with kinase activity as substrates were not equally covered by the different kinases.