Figure 4
From: Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma
Chemotherapy-induced expression of CHD5 in 12 high risk NB tumors. (A) CHD5 immunoreactivity pre- and post-chemotherapy (400x); (B) Kaplan-Meier analysis for OS was performed using the mean between pre-treatment and post-treatment gene expression levels as cut-off to divide tumors which reactivate CHD5 and tumors that maintain low expression levels; (C) CHD5 transcript levels quantified by qRT-PCR: CHD5 expression levels (Black) at diagnosis, (Grey) post-chemotherapy. Fetal brain CHD5 expression represents normal neural tissue values.