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Table 2 Univariate and multivariate Cox regression analyses PVT-1 for DFS or OS of patients in study cohort (n = 80)

From: Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16

Variables DFS OS
  HR 95% CI p value HR 95% CI p value
Univariate analysis       
Age (<50 years vs. >50 years) 0.830 0.448-1.536 0.552 0.854 0.462-1.581 0.616
Gender (male vs. female) 0.716 0.378-1.354 0.304 0.686 0.362-1.299 0.247
Location (Distal vs. Middle + Proximal) 0.711 0.383-1.322 0.281 0.668 0.359-1.241 0.201
Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated) 1.204 0.642-2.257 0.562 1.198 0.639-2.246 0.572
Invasion depth (T1 + T2 vs. T3 + T4) 0.629 0.370-1.069 0.087 0.863 0.466-1.597 0.639
TNM stage (I + II vs. III + IV) 0.377 0.198-0.720 0.003* 0.396 0.209-0.750 0.004*
Lymphatic metastasis (Yes vs. No.) 0.917 0.674-1.247 0.581 0.920 0.677-1.251 0.596
Regional lymph nodes (PN2+ PN3 vs. PN0+ PN1) 1.717 0.901-3.271 0.192 1.668 0.878-3.169 0.118
Distant metastasis (No vs. Yes) 0.255 0.073-0.892 0.032* 0.191 0.054-0.679 0.011*
Expression of PVT1 (High vs. Low) 2.691 1.418-5.109 0.002* 2.612 1.381-4.942 0.003*
Multivariate analysis       
TNM stage (I + II vs. III + IV) 0.457 0.233-0.897 0.023* 0.496 0.254-0.970 0.040*
Lymphatic metastasis (No vs. Yes) NA    NA   
Regional lymph nodes (PN0+ PN1 vs. PN2+ PN3) NA    NA   
Distant metastasis (No vs. Yes) 0.525 0.145-1.899 0.326 0.371 0.101-1.361 0.135
Expression of PVT1 (High vs. Low) 2.216 1.130-4.345 0.021* 2.092 1.068-4.096 0.031*
  1. *P<0.05.