Table 2 Univariate and multivariate Cox regression analyses PVT-1 for DFS or OS of patients in study cohort (n = 80)

Univariate analysis

Age (<50 years vs. >50 years)

0.830

0.448-1.536

0.552

0.854

0.462-1.581

0.616

Gender (male vs. female)

0.716

0.378-1.354

0.304

0.686

0.362-1.299

0.247

Location (Distal vs. Middle + Proximal)

0.711

0.383-1.322

0.281

0.668

0.359-1.241

0.201

Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated)

1.204

0.642-2.257

0.562

1.198

0.639-2.246

0.572

Invasion depth (T1 + T2 vs. T3 + T4)

0.629

0.370-1.069

0.087

0.863

0.466-1.597

0.639

TNM stage (I + II vs. III + IV)

0.377

0.198-0.720

0.003*

0.396

0.209-0.750

0.004*

Lymphatic metastasis (Yes vs. No.)

0.917

0.674-1.247

0.581

0.920

0.677-1.251

0.596

Regional lymph nodes (PN2+ PN3 vs. PN0+ PN1)

1.717

0.901-3.271

0.192

1.668

0.878-3.169

0.118

Distant metastasis (No vs. Yes)

0.255

0.073-0.892

0.032*

0.191

0.054-0.679

0.011*

Expression of PVT1 (High vs. Low)

2.691

1.418-5.109

0.002*

2.612

1.381-4.942

0.003*

Multivariate analysis

TNM stage (I + II vs. III + IV)

0.457

0.233-0.897

0.023*

0.496

0.254-0.970

0.040*

Lymphatic metastasis (No vs. Yes)

NA

NA

Regional lymph nodes (PN0+ PN1 vs. PN2+ PN3)

NA

NA

Distant metastasis (No vs. Yes)

0.525

0.145-1.899

0.326

0.371

0.101-1.361

0.135

Expression of PVT1 (High vs. Low)

2.216

1.130-4.345

0.021*

2.092

1.068-4.096

0.031*