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Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

Erratum

After publication of this study [1], we found out that we unfortunately sent two figures in duplicate. They are Fig. 4b NT and Fig. 6c NT [1]. It is important to emphasize that the results shown in the graphs are correct since they represent the mean of three independent biological assays, each of them made in technical triplicates. The photographs are only representative figures of three biological assays.

Fig. 4
figure1

PI3-K signaling pathway is involved in anoikis resistance phenotype conferred by Timp1. The MaGFP and MaT1S cell lines were treated overnight with PI3-K inhibitors, Wortmannin (a) or LY294002 (b), and their clonogenic capability was evaluated. c Melan-a melanocytes stably transfected with GFP (control transfection, MaGFP) and Timp1 (MaT1S) were maintained in suspension for 1, 3, 5 and 24 hours. The Akt activation was assessed by Western blotting. *p < 0.05, **p < 0.01, ****p < 0.0001

Fig. 6
figure2

PI3-K inhibition renders melanoma cells anoikis sensitive. The 4C11- and 4C11+ melanoma cell lines were maintained in suspension for 96 hours in the presence of Wortmannin (a and b, respectively) or LY294002 (c and d, respectively). After 96 hours, suspended cells were plated and after 5 days clonogenic capacity was analyzed. 4C11-: non-metastatic melanoma cells; 4C11+: metastatic melanoma cells; NT: non-treated; Wn: Wortmannin; LY: LY294002. *p < 0.05, **p < 0.01, ***p < 0.001

Reference

  1. 1.

    Mariana T, Fabiana HM M, Peres GB, Débora CP S, Jasiulionis MG. Timp1 interacts with beta-1integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Molecular Cancer. 2013;12:22.

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Correspondence to Miriam G. Jasiulionis.

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The authors declare that they have no competing interests.

Authors’ contributions

Conceived and designed the experiments: MT, FHMM, MGJ. Performed the experiments: MT, GBP. Analyzed the data: MT, FHMM, GBP, MGJ. Contributed reagents/materials/analysis: MT, FHMM, GBP, DCPS, MGJ. Wrote the paper: MT, FHMM, MGJ. All authors read and approved the final manuscript.

The online version of the original article can be found under doi:10.1186/1476-4598-12-22.

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Toricelli, M., Melo, F.H.M., Peres, G.B. et al. Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Mol Cancer 14, 161 (2015). https://doi.org/10.1186/s12943-015-0405-2

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