Open Access

Erratum to: ‘Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs’

  • Jodel D. Pearson1,
  • Jingxi Zhang1,
  • Zuoqiao Wu1,
  • Kayla D. Thew1,
  • Katelynn J. Rowe1,
  • Julinor T. C. Bacani2 and
  • Robert J. Ingham1Email author
Molecular Cancer201615:19

https://doi.org/10.1186/s12943-016-0499-1

Received: 9 February 2016

Accepted: 9 February 2016

Published: 1 March 2016

The original article was published in Molecular Cancer 2014 13:199

Unfortunately, the original version of this article [1] contained an error. A figure was mislabelled. In Figs. 5c and d the Doxorubicin (Doxo) concentrations should be in μM. Here is most recent version of the figure with it correctly labelled.
Fig. 5

From: Expression of granzyme B sensitizes ALK + ALCL tumour cells to apoptosis-inducing drugs. GzB knock-down reduces the sensitivity of ALK + ALCL cell lines to doxorubicin-induced apoptosis. SUP-M2 (a) or SR (b) cells expressing either control or GzB targeting shRNA were left untreated (untr.) or were treated with indicated concentrations of doxorubicin (Doxo) for 12 h at 37 °C. Cells were then lysed and lysates were probed with an anti-PARP antibody. The arrow indicates cleaved PARP. The anti-β-actin blot demonstrates equivalent protein loading. The percent cleaved PARP (% cleaved PARP) was determined by densitometry and represents the percentage of cleaved PARP as a fraction of total PARP. Molecular mass standards are indicated to the left of the western blots. SUP-M2 (c) or SR (d) cells expressing either control or GzB shRNA were left untreated (DMSO) or were treated with the indicated concentrations of doxorubicin (doxo) for 12 h at 37 °C. DNA fragmentation was then examined by TUNEL staining and results were expressed as the percentage of TUNEL-positive cells. The results shown represent the mean and standard deviation of 4 independent experiments. p values comparing cells expressing GzB shRNA to cells expressing control shRNA were obtained by performing paired, one-tailed t-tests. *p < 0.05, §p < 0.01, #p < 0.005, δp < 0.001

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Katz Group Centre for Pharmacy and Health Research, University of Alberta
(2)
Department of Laboratory Medicine and Pathology, University of Alberta

Reference

  1. Pearson JD, Zhang J, Wu Z, Thew KD, Rowe KJ, Bacani JTC, Ingham RJ. Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs. Molecular Cancer. 2014;13:199.Google Scholar

Copyright

© Pearson et al. 2016

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