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Table 1 Key Histone Methyltransferases in EMT

From: Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

HMT Histone Promoter
KDM6B H3K27m3 SNAI1
MMSET H3K36m2 TWIST
LSD1 H3K4m2 CDH1
Suv39H1 H3K9m3 CDH1
SET8 H4K20m1 CDH1
CDH2
G9a H3K9m1/2 CDH1
  1. KDM6B demethylates H3K27 at the SNAI1 promoter. MMSET can di- or trimethylate H3K36 at the TWIST promoter. LSD1 methylates H3K4m2 on CDH1. Suv39H1 can trimethylate H3K9 on the CDH1 promoter. SET8 methylates H4K20 on the CDH1 and CDH2 promoters. G9a is responsible for mono and dimethylation of H3K9