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Table 1 Key Histone Methyltransferases in EMT

From: Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

HMT

Histone

Promoter

KDM6B

H3K27m3

SNAI1

MMSET

H3K36m2

TWIST

LSD1

H3K4m2

CDH1

Suv39H1

H3K9m3

CDH1

SET8

H4K20m1

CDH1

CDH2

G9a

H3K9m1/2

CDH1

  1. KDM6B demethylates H3K27 at the SNAI1 promoter. MMSET can di- or trimethylate H3K36 at the TWIST promoter. LSD1 methylates H3K4m2 on CDH1. Suv39H1 can trimethylate H3K9 on the CDH1 promoter. SET8 methylates H4K20 on the CDH1 and CDH2 promoters. G9a is responsible for mono and dimethylation of H3K9
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Molecular Cancer

ISSN: 1476-4598