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Table 2 Univariate survival analysis of 168 patients with HCC

From: Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

Variable n Overall survival P value
2-year 5-year
CTSB expression     0.001
   Positive 90 42.5 % 19.3 %  
   Negative 78 62.8 % 43.4 %  
Gender     0.518
   Male 110 57.9 % 33.4 %  
   Female 58 60.3 % 39.6 %  
Age (years)     0.053
   <50 123 61.2 % 40.9 %  
   ≥50 45 54.1 % 35.4 %  
Tumor size (cm)a     0.001
   <5 131 68.2 % 47.6 %  
   ≥5 37 49.8 % 27.2 %  
Serum HBsAg     0.088
   Positive 147 54.3 % 36.4 %  
   Negative 21 62.3 % 43.1 %  
Serum AFP (ng/ml)     0.001
   <25 50 70.3 % 51.3 %  
   ≥25 118 52.6 % 33.3 %  
Cirrhosis     0.031
   Presence 145 52.9 % 23.3 %  
   Absence 23 63.7 % 43.6 %  
UICC stage     0.001
   I + II 100 75.2 % 49.8 %  
   III + IV 68 50.1 % 24.5 %  
Metastasis/Recurrence     0.000
   Yes 133 43.4 % 23.3 %  
   No 35 67.2 % 40.7 %  
Edmondson grade     0.005
   Low (I/II) 82 66.9 % 42.8 %  
   High (III/IV) 86 48.3 % 27.1 %  
  1. a:The largest dimension of the tumor specimen