Table 3 Comparison of different types of carriers for RNAi molecules

Viral vectors

Integrated into the host chromosome

Suitable for splinter cells and the cells that are difficult to transfect; can transfect targeting cells naturally and efficiently

1. Improve the effectiveness

2. Improve the specificity

3. Lower toxicity

Lipids

Conjugate or complexing

High drug entrapment efficiency; adjustable continuous release behavior and good serum stability; ability to protect the medicine from degradation; no immunogenicity

Polymers

Combined with the skeleton phosphate or connected to the adapter body

Low transfection efficiency

Bacteria

Specific antibodies

Non-toxicity, lack of side effects, can be manipulated