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Table 1 mRNAs showing Fhit-dependent changes in ribosome loading

From: Impact of FHIT loss on the translation of cancer-associated mRNAs

Symbol

Gene ID

Log2 D1/E1

Coding region

 CDKN2C

NM_001262

3.47

 IGSF9

NM_020789

3.42

 ATG16L2

NM_033388

3.39

 TP53I3

NM_004881

2.18

 MECP2

NM_004992

1.48

 CSRP2

NM_001321

1.31

 EEF2

NM_001961

−0.81

 GDA

NM_001242505

−1.31

 IFIT1

NM_001548

−2.37

 LRRC73

NM_001012974

−4.39

5’-UTR

 ACSL1

NM_001995

3.69

 TROVE2

NM_004600

3.47

 ADAM9

NM_003816

1.51

 HIST1H2AD

NM_021065

1.30

 H2AFZ

NM_002106

0.72

 RACK1

NM_006098

−0.88

 RPL37A

NM_000998

−2.01

  1. The Average Ribosome Density (ARD) for Ponasterone A-treated E1 and D1 cells was determined using RiboDiff and only those transcripts with an adjusted p value <0.05 were considered further. Column 3 shows the log2 induction ratio + Fhit(D1)/ -Fhit (E1). The upper panel lists mRNAs with changes in ribosomes bound to coding regions. The lower panel lists mRNAs with changes in ribosomes bound to the 5’-UTR using a cutoff of 25 nucleotides upstream of the annotated start codon
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Molecular Cancer

ISSN: 1476-4598