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Table 3 Targets of Fhit-mediated changes in ribosome occupancy

From: Impact of FHIT loss on the translation of cancer-associated mRNAs

Gene Function Changes in ribosome occupancy with Fhit induction
ACSL1 Acyl-CoA synthetase, functions in lipid metabolism by converting long chain fatty acids into their CoA esters Increased 5’-UTR
ATG16L2 Autophagy Related 16 Like 2, paralog of ATG16L1, which functions in a complex needed for autophagy Increased CDS
ADAM9 A Disintegrin And Metalloproteinase Domain 9, involved in cell-cell interactions, cell-matrix interactions Increased 5’-UTR
CALR Calreticulin, a major Ca(2+)-binding (storage) protein Decreased 5’-UTR, CDS unchanged
CDKN2C Cyclin Dependent Kinase Inhibitor 2C, a member of the INK4 family of cyclin-dependent kinase inhibitors that regulate cyclin-dependent kinases Increased CDS
CLPTM1 Cleft Lip And Palate Associated Transmembrane Protein 1, a paralog of CLPTM1, has a role in susceptibility to cisplatin Increased 5’-UTR, CDS unchanged
CREBL2 cAMP Responsive Element Binding Protein Like 2, transcription factor associated with lung cancers Decreased 5’-UTR, increased CDS
CSRP2 Cysteine And Glycine Rich Protein 2, a member of the CSRP family encoding LIM domain proteins involved in cellular differentiation Increased CDS
DCAF5 DDB1 And CUL4 Associated Factor 5, a ubiquitin ligase that regulates cell proliferation, survival, DNA repair, and genomic integrity Increased 5’-UTR and CDS
EEF2 Eukaryotic Translation Elongation Factor 2, GTP-binding translation factor that facilitates movement of tRNA-bound peptides from the ribosome A site to the P site. Decreased CDS
FASN Fatty Acid Synthase, catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA. Also an mRNA-binding protein. Increased 5’-UTR, CDS unchanged
FBLN1 Fibulin 1, a secreted glycoprotein that is incorporated into the extracellular matrix Decreased 5’-UTR, CDS unchanged
GDA Guanine Deaminase Decreased CDS
HINT2 Histidine Triad Nucleotide Binding Protein 2, a member of the superfamily of histidine triad proteins, functions in mitochondrial cell death signaling Increased 5’-UTR, CDS unchanged
HIST1H2AD Histone Cluster 1 H2A Family Member D Increased 5’-UTR
H2AFZ H2A Histone Family Member Z, regulates epithelial-mesenchymal transition, evidence for a role in repressing lncRNA Increased 5’-UTR
IFIT1 Interferon Induced Protein With Tetratricopeptide Repeats 1, antiviral protein targeting RNAs with 5′-triphosphate ends Decreased CDS
IGSF9 Immunoglobulin Superfamily Member 9, molecule involved in cell-cell interaction Increased CDS
KPNB1 Karyopherin Subunit Beta 1, subunit of the importin alpha complex that binds the nuclear localization signal, functions in importing proteins into the nucleus Increased 5’-UTR, CDS unchanged
LRRC73 Leucine Rich Repeat Containing 73, no known function Decreased CDS
MECP2 Methyl-CpG Binding Protein 2, mediates transcriptional silencing by binding methyl CpG in DNA, mutations result in Rett syndrome, neurological Increased CDS
RACK1 Receptor For Activated C Kinase 1, component of the 40S ribosome subunit, involved in signaling between protein kinase pathways and translation Decreased 5’-UTR
RPL37A Ribosomal Protein L37A, constituent of the large ribosome subunit Decreased 5’-UTR
SERTAD3 SERTA Domain Containing 3, a transcriptional coactivator Increased 5’-UTR and CDS
TBC1D7 Subunit of the tuberous sclerosis TSC1-TSC2 complex Increased 5’-UTR and CDS
TP53I3 Tumor Protein P53 Inducible Protein 3, an oxidoreductase that is induced by TP53 Increased CDS
TIAM1 T-cell Lymphoma Invasion And Metastasis 1, encodes a RAC1-specific guanine nucleotide exchange factor Increased 5’-UTR and CDS
TROVE2 TROVE Domain Family Member 2, binds misfolded ncRNAs including Y RNAs Increased 5’-UTR
ZCCHC3 Zinc finger protein of unknown function, interacts with a large number of proteins, including ELAV1, LIN28B, PAIP1, RACK1, NANOG Increased 5’-UTR and CDS
ZNF552 Zinc Finger Protein 552, unknown function Decreased 5’-UTR, increased CDS
  1. This table lists all of the mRNAs (genes) for which changes in Fhit expression alter ribosome binding of the CDS, ribosome binding of the 5’-UTR, or the ratio of ribosomes bound to the 5’-UTR versus coding region (CDS)