Table 3 Targets of Fhit-mediated changes in ribosome occupancy
From: Impact of FHIT loss on the translation of cancer-associated mRNAs
Gene | Function | Changes in ribosome occupancy with Fhit induction |
|---|---|---|
ACSL1 | Acyl-CoA synthetase, functions in lipid metabolism by converting long chain fatty acids into their CoA esters | Increased 5’-UTR |
ATG16L2 | Autophagy Related 16 Like 2, paralog of ATG16L1, which functions in a complex needed for autophagy | Increased CDS |
ADAM9 | A Disintegrin And Metalloproteinase Domain 9, involved in cell-cell interactions, cell-matrix interactions | Increased 5’-UTR |
CALR | Calreticulin, a major Ca(2+)-binding (storage) protein | Decreased 5’-UTR, CDS unchanged |
CDKN2C | Cyclin Dependent Kinase Inhibitor 2C, a member of the INK4 family of cyclin-dependent kinase inhibitors that regulate cyclin-dependent kinases | Increased CDS |
CLPTM1 | Cleft Lip And Palate Associated Transmembrane Protein 1, a paralog of CLPTM1, has a role in susceptibility to cisplatin | Increased 5’-UTR, CDS unchanged |
CREBL2 | cAMP Responsive Element Binding Protein Like 2, transcription factor associated with lung cancers | Decreased 5’-UTR, increased CDS |
CSRP2 | Cysteine And Glycine Rich Protein 2, a member of the CSRP family encoding LIM domain proteins involved in cellular differentiation | Increased CDS |
DCAF5 | DDB1 And CUL4 Associated Factor 5, a ubiquitin ligase that regulates cell proliferation, survival, DNA repair, and genomic integrity | Increased 5’-UTR and CDS |
EEF2 | Eukaryotic Translation Elongation Factor 2, GTP-binding translation factor that facilitates movement of tRNA-bound peptides from the ribosome A site to the P site. | Decreased CDS |
FASN | Fatty Acid Synthase, catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA. Also an mRNA-binding protein. | Increased 5’-UTR, CDS unchanged |
FBLN1 | Fibulin 1, a secreted glycoprotein that is incorporated into the extracellular matrix | Decreased 5’-UTR, CDS unchanged |
GDA | Guanine Deaminase | Decreased CDS |
HINT2 | Histidine Triad Nucleotide Binding Protein 2, a member of the superfamily of histidine triad proteins, functions in mitochondrial cell death signaling | Increased 5’-UTR, CDS unchanged |
HIST1H2AD | Histone Cluster 1 H2A Family Member D | Increased 5’-UTR |
H2AFZ | H2A Histone Family Member Z, regulates epithelial-mesenchymal transition, evidence for a role in repressing lncRNA | Increased 5’-UTR |
IFIT1 | Interferon Induced Protein With Tetratricopeptide Repeats 1, antiviral protein targeting RNAs with 5′-triphosphate ends | Decreased CDS |
IGSF9 | Immunoglobulin Superfamily Member 9, molecule involved in cell-cell interaction | Increased CDS |
KPNB1 | Karyopherin Subunit Beta 1, subunit of the importin alpha complex that binds the nuclear localization signal, functions in importing proteins into the nucleus | Increased 5’-UTR, CDS unchanged |
LRRC73 | Leucine Rich Repeat Containing 73, no known function | Decreased CDS |
MECP2 | Methyl-CpG Binding Protein 2, mediates transcriptional silencing by binding methyl CpG in DNA, mutations result in Rett syndrome, neurological | Increased CDS |
RACK1 | Receptor For Activated C Kinase 1, component of the 40S ribosome subunit, involved in signaling between protein kinase pathways and translation | Decreased 5’-UTR |
RPL37A | Ribosomal Protein L37A, constituent of the large ribosome subunit | Decreased 5’-UTR |
SERTAD3 | SERTA Domain Containing 3, a transcriptional coactivator | Increased 5’-UTR and CDS |
TBC1D7 | Subunit of the tuberous sclerosis TSC1-TSC2 complex | Increased 5’-UTR and CDS |
TP53I3 | Tumor Protein P53 Inducible Protein 3, an oxidoreductase that is induced by TP53 | Increased CDS |
TIAM1 | T-cell Lymphoma Invasion And Metastasis 1, encodes a RAC1-specific guanine nucleotide exchange factor | Increased 5’-UTR and CDS |
TROVE2 | TROVE Domain Family Member 2, binds misfolded ncRNAs including Y RNAs | Increased 5’-UTR |
ZCCHC3 | Zinc finger protein of unknown function, interacts with a large number of proteins, including ELAV1, LIN28B, PAIP1, RACK1, NANOG | Increased 5’-UTR and CDS |
ZNF552 | Zinc Finger Protein 552, unknown function | Decreased 5’-UTR, increased CDS |