Table 1 In vivo studies of natural products against hematological malignancies

HSS(Haishengsu)

Nude mice

450,900,1800 mg/kg bw, intravenous

↓Bcr-Abl

[213]

Triptolide

Nu/nu BALB/c mice

0.15 mg/kg Bw, subcutaneous

↓Bcr-Abl

[214]

curcumin

Balb/c mice

40 mg/kg bw, intraperitonial

↓c-ABL

[216]

Berbamine(BBM)

Balb/c

60 mg/kg bw, intravenously

↓p-gp protein

[220]

4-Chlorobenzoyl berbamine(BBD9)

NU−/−

15 and 30 mg/kg BW,

↓P-BCR-ABL

[223]

Tetrandrine citrate

Nu−/−

100 mg/kg BW, orally

↓BCR-ABL

[225]

homoharringtonine

BABL/c mice

0.5–1 mg/kg BW, intraperitonial

↓Bcr-Abl

[186]

Oroxylin A

SCID

80MG/KG BW, intravenously

↓STAT3,p-gp

[227]

chlorogenic acid

Nude mice

25-150 mg/kg bw, intraperitonial

↓Bcr-Abl

[228]

Celastrol

Nu/nu BalB/c Mice

1 mg/kg BW, intraperitonial

↓Bcr-Abl

[229]

Pristimerin

nu/nu BALB/c mice

1 mg/kg Bw, intratumoral

↓Bcr-Abl

[230]

Herbimycin A

Balb/c nude mice

15 μg,intraperitonial

↓abl

[232]