Fig. 2
From: Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
m6A modification functions as a ‘dual-edged sword’ in tumor progression. In AML, aberrant FTO, METTL14 and METTL3 lead to aberrant expression of the ASB2, RARA, MYC, MYB, BCL2, SP1 and PTEN genes through m6A modification, ultimately promoting tumorigenesis. In GSCs, aberrant METTL3, METTL14 and ALKBH5 lead to the aberrant expression of ADAM19 and FOXM1 through m6A modifications, ultimately promoting tumorigenesis. In HCC, aberrant METTL3 and METTL14 lead to the aberrant expression of SOCS2 and miR126 through m6A modifications, ultimately promoting tumorigenesis. In BCSCs, aberrant METTL3 leads to the aberrant expression of KLF4, NANOG and HBXIP through m6A modifications, ultimately promoting tumorigenesis. In cervical cancer, aberrant FTO leads to the aberrant expression of β-catenin