Table 1 m⁶A chemical modifications affect physiological function

Spermatogenesis

Plzf, Dnmt3b Id4 and Sohlh2

Deletion of m⁶A results in the dysregulation of spermatogenesis

[39]

T cell homeostasis

SOCS1, SOCS3 and CISH

Decreased m⁶A modification inhibits naive T cell proliferation and differentiation but maintains cell survival

[40]

Drosophila sex determination

Sxl

YT521-B reads the m⁶A modification of Sxl to promote Sxl alternative splicing, which determines female physiognomy

[38]

Heat shock response

Hsp105

Under heat shock stress, m⁶A is preferentially deposited at the 5’UTR of new stress-inducible transcripts, such as Hsp105 (HSPH1), and enhances cap-independent translation initiation

[28]

Somatic cell reprogramming and pluripotency of ESCs

Nanog, Sox2, Klf4 and c-Myc

High m⁶A modification levels accelerate mRNA degradation of these genes, which damages ESC self-renewal and somatic cell reprogramming

[37]