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Fig. 2 | Molecular Cancer

Fig. 2

From: N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

Fig. 2

Mechanism of m6A methylation m6A-RNA methylation is regulated by its “writer”, “eraser” and “reader”, the writer refers to the m6A-methylase complex, mainly including METTL3, METTL14, METTL16 and WTAP. The eraser is an m6A-demethylase complex, including FTO and ALKBH5. The reader is a protein that binds to m6A and includes proteins containing the YTH domain (YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2), which involving splicing, export, translation, RNA decay

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Molecular Cancer

ISSN: 1476-4598