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Correction to: Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals

The Original Article was published on 12 November 2018

Correction to: Mol Cancer 17, 157 (2018)

https://doi.org/10.1186/s12943-018-0906-x

Following publication of the original article [1], a minor error was identified in the images presented in Fig. 1; specifically:

Fig. 1F: incorrect image used for representative image of invasive cells induced by transfection of miR-452-5p in OSRC-2 with treatment of 10 μM Sunitinib (top left image); the image has been corrected.

The corrected figure is given here. The correction does not have any effect on the results or conclusions of the paper.

Fig. 1
figure 1

Sunitinib abrogates RCC cell invasion and metastasis via depressing miR-452-5p. a Presented are heatmap of the most differentially expressed miRNAs in peripheral blood under Sunitinib treatment (GSE32099) and between tumor tissue and pair-matched normal tissues(GSE37989). b The above analysis showed 10 miRNAs were significantly differentially expressed both in GSE32099 and GSE37989. c qRT-PCR assays for miR-452-5p expression with 0, 5 and 10 μM Sunitinib treatment in OSRC-2 and SW839 cells. d-e Representative micrographs of wound-healing assay and decrease in wound width was induced by transfection of miR-452-5p in OSRC-2 and SW839 cells versus miR-NC cells with treatment of 10 μM Sunitinib. f-g Representative images and number of invasive cells per high-power field was induced by transfection of miR-452-5p in OSRC-2 and SW839 cells versus miR-NC cells with treatment of 10 μM Sunitinib. h Orthotopic xenograft animal models were generated using miR-452-5p or miR-NC in OSRC-2 cells and mice treated with 10 μM Sunitinib. Presented are representative images (left) of abdominal metastasis viewed by IVIS system in each group 4 weeks after the orthotopic xenograft transplantation (n=8) and Quantitation of metastasis nodules shown at right. i Incidence of metastasis in orthotopic xenografts after 4 weeks. j TCGA cohort analysis of the differentially expressed levels of miR-452-5p in RCC tumor samples and pair-matched normal tissues. Each dot represents one sample. k Comparison of miR-452-5p expression in 20 paired RCC tumor tissues and adjacent normal tissues via qRT-PCR. l Relative miR-452-5p expression levels in RCC samples are presented as fold change=2(∆Ct normal-∆Ct tumor) of tumor versus matched normal tissues, 85% of which was upregulated in tumor tissues than adjacent normal tissues. m miR-452-5p expression in a series of RCC cell lines (SW839, A498, SN12-PM6 and OSRC-2) and human normal renal tubular epithelial cell line HK-2. n ROC analysis to assess the specificity and sensitivity of miR-452-5p to differentiate between RCC and normal tissues. o Kaplan–Meier analyses of the correlations between miR-452-5p expression level and overall survival of 806 patients with RCC through TCGA analysis. The median expression level was used as the cutoff. Data shown are mean±S.D. *p<0.05, **p<0.01

Reference

  1. Zhai W, Li S, Zhang J, et al. Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals. Mol Cancer. 2018;17:157. https://doi.org/10.1186/s12943-018-0906-x.

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Correspondence to Wei Zhai, Wei Xue or Yunfei Xu.

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Zhai, W., Li, S., Zhang, J. et al. Correction to: Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals. Mol Cancer 21, 96 (2022). https://doi.org/10.1186/s12943-022-01568-y

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  • DOI: https://doi.org/10.1186/s12943-022-01568-y