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Correction: CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-IRNA-editing

The Original Article was published on 09 March 2021

Correction: Mol Cancer 20, 51 (2021)

https://doi.org/10.1186/s12943-021-01333-7

In our BMC Research publication in Molecular Cancer entitled ‘CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing ’[1], we misplaced two images in Fig. 2C and Fig.S3D. These errors inadvertently happened during the stage of our figure assembly with photoshop software. The corrected version of Fig. 2 and Fig.S3 has been provided.

Fig 2
figure 1

CircNEIL3 promotes the proliferation, migration and invasion of PDAC cells in vitro. a. RT-qPCR analysis of circNEIL3 and NEIL3 mRNA expression in CFPAC-1 and MiaPaca-2 cells transfected with a lentivirus and circNEIL3 plasmid. b. The growth curves of cells were evaluated by CCK-8 assays after knocking down and overexpressing circNEIL3 in CFPAC-1 and MiaPaca-2 cells. c-d. Colony formation assays were performed to evaluate cell proliferation. e-f. EdU assays of PDAC cells was performed to evaluate cell proliferation. The samples were imaged at 200× magnification. Scale bar = 50 μm. g-h. Transwell assays were performed to assess the migration and invasion abilities of PDAC cells. The samples were imaged at 100× magnification. Scale bar = 100 μm. i-j. Cell migration was assessed using a wound healing assay. The samples were imaged at 100× magnification. Scale bar = 100 μm. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

The correction does not affect the conclusion or discussion of this article.

Reference

  1. Shen P, Yang T, Chen Q, et al. CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing. Mol Cancer. 2021;20:51. https://doi.org/10.1186/s12943-021-01333-7.

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Correspondence to Zipeng Lu or Kuirong Jiang.

Supplementary Information

Additional file 1: Figure S3

. ADAR1 downregulation reverses the oncogenic phenotype induced by circNEIL3 overexpression. a-i. CCK-8, colony formation, EdU, transwell and wound healing assay results showed that transfection with the ADAR1 shRNA inhibited the proliferation, migration, and invasion abilities of MiaPaca-2 cells, which was reversed after cotransfection with the circNEIL3 plasmid. The EdU samples were imaged at 200× magnification. Scale bar = 50 μm. The transwell and hound healing samples were imaged at 100× magnification. Scale bar = 100 μm. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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Shen, P., Yang, T., Chen, Q. et al. Correction: CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-IRNA-editing. Mol Cancer 21, 165 (2022). https://doi.org/10.1186/s12943-022-01636-3

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  • DOI: https://doi.org/10.1186/s12943-022-01636-3