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Correction: Comprehensive review of CRISPR‑based gene editing: mechanisms, challenges, and applications in cancer therapy

The Original Article was published on 09 January 2024

Correction: Mol Cancer 23, 9 (2024)

Following publication of the original article [1], it has come to the author's attention that this article cites their work in an incorrect fashion and at least the related part of the paper raises some concern about the integrity of the reported information.

In Table 3 on clinical trials of CRISPR-based therapy of the manuscript, the authors cite our study (Ref 202 in the article, and claim they demonstrated HPRT1-KO in cancer cells as a treatment strategy. Unfortunately, this statement does not reflect our study. They demonstrated for the first time that non-viral knock-in of CD19-specific CAR into primary human T cells is possible and effective with non-viral dsDNA templates (e.g. related to Fig. 11 of the Molecular Cancer article). This study was completely pre-clinical and had no relation to HPRT1.

After this perplexing finding, the corresponding author took some time to check other references of Table 3 and discovered that other references (such as References 201, 198, 197 that he checked) were also wrong. Glancing at other references in Table 3, it seems the authors cited predominantly review articles instead of original articles and at least some of the content was completely misaligned to the topic (e.g. Ref 198 cites a review on transplantation and GvhD; no relation to cancer therapy). Some of the related content is also non-sensical, suggesting either inexperience by the person preparing the table or potentially the use of a flawed AI tool. The correct Table 3 is given below.

Table 3 Clinical trials of CRISPR-based cancer therapy


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Correspondence to Mohammad Chehelgerdi.

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Chehelgerdi, M., Chehelgerdi, M., Khorramian‑Ghahfarokhi, M. et al. Correction: Comprehensive review of CRISPR‑based gene editing: mechanisms, challenges, and applications in cancer therapy. Mol Cancer 23, 43 (2024).

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