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  1. Insertional mutagenesis screens have been used with great success to identify oncogenes and tumor suppressor genes. Typically, these screens use gammaretroviruses (γRV) or transposons as insertional mutagens. ...

    Authors: Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows and Grant D Trobridge
    Citation: Molecular Cancer 2014 13:120
    Content type: Research Published on:

  2. Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon ar...

    Authors: Kelong Ma, Xiaorong Pan, Pingsheng Fan, Yinghua He, Jun Gu, Wei Wang, Tengyue Zhang, Zonghai Li and Xiaoying Luo
    Citation: Molecular Cancer 2014 13:118
    Content type: Research Published on:

  3. Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of Sfrp1 expression is observed in breast cancer. The molecular mechanisms by which obesity con...

    Authors: Kelly J Gauger, Lotfi M Bassa, Elizabeth M Henchey, Josephine Wyman, Jennifer Ser-Dolansky, Akihiko Shimono and Sallie S Schneider
    Citation: Molecular Cancer 2014 13:117
    Content type: Short communication Published on:

  4. The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have pr...

    Authors: Ingvild Haaland, Jill A Opsahl, Frode S Berven, Håkon Reikvam, Hanne K Fredly, Ragnhild Haugse, Bernd Thiede, Emmet McCormack, Sonia Lain, Øystein Bruserud and Bjørn Tore Gjertsen
    Citation: Molecular Cancer 2014 13:116
    Content type: Research Published on:

  6. We investigated whether combinations of serum cytokines, used with logistic disease predictor models, could facilitate the detection of pancreatic ductal adenocarcinoma (PDAC).

    Authors: Victoria E Shaw, Brian Lane, Claire Jenkinson, Trevor Cox, William Greenhalf, Christopher M Halloran, Joseph Tang, Robert Sutton, John P Neoptolemos and Eithne Costello
    Citation: Molecular Cancer 2014 13:114
    Content type: Research Published on:

  7. Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emerg...

    Authors: Zuzana Pernicová, Eva Slabáková, Radek Fedr, Šárka Šimečková, Josef Jaroš, Tereza Suchánková, Jan Bouchal, Gvantsa Kharaishvili, Milan Král, Alois Kozubík and Karel Souček
    Citation: Molecular Cancer 2014 13:113
    Content type: Research Published on:

  8. Transforming Growth Factor beta (TGF-β) acts as a tumor suppressor early in carcinogenesis but turns into tumor promoter in later disease stages. In fact, TGF-β is a known inducer of integrin expression by tum...

    Authors: Elizabeth Salvo, Saray Garasa, Javier Dotor, Xabier Morales, Rafael Peláez, Peter Altevogt and Ana Rouzaut
    Citation: Molecular Cancer 2014 13:112
    Content type: Research Published on:

  9. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that acts as a prognostic marker for several human malignancies. In this study, we investigated the clinical significance of CIP2A and it...

    Authors: Na Liu, Qing-Mei He, Jie-Wei Chen, Ying-Qin Li, Ya-Fei Xu, Xian-Yue Ren, Ying Sun, Hai-Qiang Mai, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng and Jun Ma
    Citation: Molecular Cancer 2014 13:111
    Content type: Research Published on:

  10. The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 an...

    Authors: Kangsheng Tu, Wei Yang, Chao Li, Xin Zheng, Zhongtang Lu, Cheng Guo, Yingmin Yao and Qingguang Liu
    Citation: Molecular Cancer 2014 13:110
    Content type: Research Published on:

  11. Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still ...

    Authors: Xin Xu, Jian Wu, Shiqi Li, Zhenghui Hu, Xianglai Xu, Yi Zhu, Zhen Liang, Xiao Wang, Yiwei Lin, Yeqing Mao, Hong Chen, Jindan Luo, Ben Liu, Xiangyi Zheng and Liping Xie
    Citation: Molecular Cancer 2014 13:109
    Content type: Research Published on:

  12. DUSP3 phosphatase, also known as V accinia-H 1 R elated (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP...

    Authors: Mathieu Amand, Charlotte Erpicum, Khalid Bajou, Fabio Cerignoli, Silvia Blacher, Maud Martin, Franck Dequiedt, Pierre Drion, Pratibha Singh, Tinatin Zurashvili, Maud Vandereyken, Lucia Musumeci, Tomas Mustelin, Michel Moutschen, Christine Gilles, Agnes Noel…
    Citation: Molecular Cancer 2014 13:108
    Content type: Research Published on:

  13. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, has a dual role in mitosis and in apoptosis. It is abundantly expressed in every human tumor, compared with normal tissues. During mitosis Su...

    Authors: Ralf Wiedemuth, Barbara Klink, Katrin Töpfer, Evelin Schröck, Gabriele Schackert, Masaaki Tatsuka and Achim Temme
    Citation: Molecular Cancer 2014 13:107
    Content type: Research Published on:

  14. Acylglycerol kinase (AGK) is reported to be overexpressed in multiple cancers. The clinical significance and biological role of AGK in breast cancer, however, remain to be established.

    Authors: Xi Wang, Chuyong Lin, Xiaohui Zhao, Aibin Liu, Jinrong Zhu, Xinghua Li and Libing Song
    Citation: Molecular Cancer 2014 13:106
    Content type: Research Published on:

  16. Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (sno...

    Authors: Kaiissar Mannoor, Jun Shen, Jipei Liao, Zhenqiu Liu and Feng Jiang
    Citation: Molecular Cancer 2014 13:104
    Content type: Research Published on:

  17. Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in vivo studies have demonstrated the therapeutic effects of inhibiti...

    Authors: Nathaniel Weygant, Dongfeng Qu, William L Berry, Randal May, Parthasarathy Chandrakesan, Daniel B Owen, Sripathi M Sureban, Naushad Ali, Ralf Janknecht and Courtney W Houchen
    Citation: Molecular Cancer 2014 13:103
    Content type: Research Published on:

  18. Homeobox B9 (HOXB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as one of important transcriptional factors related to angiogenesis. This...

    Authors: Yoshinori Hoshino, Tetsu Hayashida, Akira Hirata, Hidena Takahashi, Naokazu Chiba, Mitsuyo Ohmura, Masatoshi Wakui, Hiromitsu Jinno, Hirotoshi Hasegawa, Shyamala Maheswaran, Makoto Suematsu and Yuko Kitagawa
    Citation: Molecular Cancer 2014 13:102
    Content type: Research Published on:

  19. Over 90% of cancer-related deaths in clear cell renal cell carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy o...

    Authors: Hala Girgis, Olena Masui, Nicole MA White, Andreas Scorilas, Fabio Rotondo, Annetta Seivwright, Manal Gabril, Emily R Filter, Andrew HA Girgis, Georg A Bjarnason, Michael AS Jewett, Andrew Evans, Sahar Al-Haddad, KW Michael Siu and George M Yousef
    Citation: Molecular Cancer 2014 13:101
    Content type: Research Published on:

  20. Elevated MELK expression is featured in multiple tumors and correlated with tumorigenesis and tumor development. This study is aimed to investigate the mechanisms of MELK-mediated development of gastric cancer.

    Authors: Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu and Bingya Liu
    Citation: Molecular Cancer 2014 13:100
    Content type: Research Published on:

  21. Vasohibin-2 (VASH2) has been identified as an endogenous and vascular endothelial growth factor (VEGF)-independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to d...

    Authors: Shuji Kitahara, Yasuhiro Suzuki, Masae Morishima, Asuka Yoshii, Sachiko Kikuta, Kazuhiko Shimizu, Shunichi Morikawa, Yasufumi Sato and Taichi Ezaki
    Citation: Molecular Cancer 2014 13:99
    Content type: Research Published on:

  22. Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the an...

    Authors: Bin Wang, Zhenhong Ni, Xufang Dai, Liyan Qin, Xinzhe Li, Liang Xu, Jiqin Lian and Fengtian He
    Citation: Molecular Cancer 2014 13:98
    Content type: Research Published on:

  23. We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with the malignant phenotype.

    Authors: Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, Mohamed Kamel Hassan, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka and Noriaki Sakuragi
    Citation: Molecular Cancer 2014 13:97
    Content type: Research Published on:

    The Erratum to this article has been published in Molecular Cancer 2014 13:140

  24. Ras guanine nucleotide exchange factors (RasGEFs) mediate the activation of the Ras signaling pathway that is over activated in many human cancers. The RasGRP3, an activator of H-Ras and R-Ras protein exerts o...

    Authors: Zsuzsanna Nagy, Ilona Kovács, Miklós Török, Dezső Tóth, György Vereb, Krisztina Buzás, István Juhász, Peter M Blumberg, Tamás Bíró and Gabriella Czifra
    Citation: Molecular Cancer 2014 13:96
    Content type: Research Published on:

  25. Grb2 (Growth factor receptor-bound protein 2) is a key adaptor protein in maintaining the ERK activity via linking Sos1 (Son of sevenless homolog 1) or other proteins to activated RTKs, such as EGFR. Currently, l...

    Authors: Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu and Jian Huang
    Citation: Molecular Cancer 2014 13:95
    Content type: Research Published on:

  26. It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipula...

    Authors: Yan Wang, Ziliang Wang, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang, Zhen Zhang and Gong Yang
    Citation: Molecular Cancer 2014 13:94
    Content type: Research Published on:

  27. Osteosarcomas are the most common primary malignant tumors of bone, showing complex chromosomal rearrangements with multiple gains and losses. A frequent deletion within the chromosomal region 3q13.31 has been...

    Authors: Tale Barøy, Stine H Kresse, Magne Skårn, Marianne Stabell, Russell Castro, Silje Lauvrak, Antonio Llombart-Bosch, Ola Myklebost and Leonardo A Meza-Zepeda
    Citation: Molecular Cancer 2014 13:93
    Content type: Research Published on:

  28. Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of HOTAIR in gastr...

    Authors: Xiang-hua Liu, Ming Sun, Feng-qi Nie, Ying-bin Ge, Er-bao Zhang, Dan-dan Yin, Rong Kong, Rui Xia, Kai-hua Lu, Jin-hai Li, Wei De, Ke-ming Wang and Zhao-xia Wang
    Citation: Molecular Cancer 2014 13:92
    Content type: Research Published on:

  29. The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of HIF-mediated transcription has potential in the treatm...

    Authors: Kelie M Reece, Emily D Richardson, Kristina M Cook, Tessa J Campbell, Stephen T Pisle, Alesia J Holly, David J Venzon, David J Liewehr, Cindy H Chau, Douglas K Price and William D Figg
    Citation: Molecular Cancer 2014 13:91
    Content type: Research Published on:

  31. TFAP2B is a member of the AP2 transcription factor family, which orchestrates a variety of cell processes. However, the roles of TFAP2B in regulating carcinogenesis remain largely unknown. Here, we investigate...

    Authors: Lingyi Fu, Ke Shi, Jingshu Wang, Wangbing Chen, Dingbo Shi, Yun Tian, Wei Guo, Wendan Yu, Xiangsheng Xiao, Tiebang Kang, Shusen Wang, Wenlin Huang and Wuguo Deng
    Citation: Molecular Cancer 2014 13:89
    Content type: Research Published on:

  32. Wnt proteins are important for developmental processes and certain diseases. WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the progression of malignant melanoma. High ex...

    Authors: Elin J Ekström, Caroline Bergenfelz, Verena von Bülow, Filiz Serifler, Eric Carlemalm, Göran Jönsson, Tommy Andersson and Karin Leandersson
    Citation: Molecular Cancer 2014 13:88
    Content type: Research Published on:

  33. The Polo-like Kinase 1 (PLK1) protein regulates cell cycle progression and is overexpressed in many malignant tissues. Overexpression is associated with poor prognosis in several cancer entities, whereby expre...

    Authors: Neval Akdeli, Kathrin Riemann, Jana Westphal, Jochen Hess, Winfried Siffert and Hagen S Bachmann
    Citation: Molecular Cancer 2014 13:87
    Content type: Research Published on:

  34. Given the emerging role of microRNA in tumor disease progression, we investigated the association between microRNA expression, liver metastasis and prognosis of colorectal cancer.

    Authors: Dengbo Ji, Zhiguo Chen, Ming Li, Tiancheng Zhan, Yunfeng Yao, Zhiqian Zhang, Jianzhong Xi, Li Yan and Jin Gu
    Citation: Molecular Cancer 2014 13:86
    Content type: Research Published on:

  35. Stimulation of CD40 can augment anti-cancer T cell immune responses by triggering effective activation and maturation of antigen-presenting cells (APCs). Although CD40 agonists have clinical activity in humans...

    Authors: Kim L Brunekreeft, Corinna Strohm, Marloes J Gooden, Anna A Rybczynska, Hans W Nijman, Götz U Grigoleit, Wijnand Helfrich, Edwin Bremer, Daniela Siegmund, Harald Wajant and Marco de Bruyn
    Citation: Molecular Cancer 2014 13:85
    Content type: Research Published on:

  36. E2F1 is the gatekeeper of the cell cycle controlling an analogous balance between proliferation and cell death. E2F1 expression is elevated in advanced prostate cancer. However, it is still unclear that the ro...

    Authors: Zijia Ren, Wenyao Kang, Lihua Wang, Baoliang Sun, Jiajia Ma, Chaogu Zheng, Jie Sun, Zhigang Tian, Xiaoyi Yang and Weihua Xiao
    Citation: Molecular Cancer 2014 13:84
    Content type: Research Published on:

  37. The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway c...

    Authors: Amanda Lassen, Mohammad Atefi, Lidia Robert, Deborah JL Wong, Michael Cerniglia, Begonya Comin-Anduix and Antoni Ribas
    Citation: Molecular Cancer 2014 13:83
    Content type: Research Published on:

  38. Gallbladder carcinoma (GBC) is highly lethal, and effective treatment will require synergistic anti-tumor management. The study is aimed at investigating the oncolytic value of myxoma virus (MYXV) infection ag...

    Authors: Mingzhe Weng, Wei Gong, Mingzhe Ma, Bingfeng Chu, Yiyu Qin, Mingdi Zhang, Xueqing Lun, Grant McFadden, Peter Forsyth, Yong Yang and Zhiwei Quan
    Citation: Molecular Cancer 2014 13:82
    Content type: Research Published on:

  39. The molecular mechanisms responsible for angiogenesis and abnormal expression of angiogenic factors in gastric cancer, including vascular endothelial growth factor (VEGF), remain unclear. The histone demethyla...

    Authors: Lupeng Li, Lixiang Wang, Ping Song, Xue Geng, Xiuming Liang, Minran Zhou, Yangyang Wang, Chunyan Chen, Jihui Jia and Jiping Zeng
    Citation: Molecular Cancer 2014 13:81
    Content type: Research Published on:

  40. While microRNAs (miRNAs) are extensively studied in post-transcriptional regulation of gene expressions in many biological processes, cellular miRNA-mediated regulation of viral genes remains unclear. In parti...

    Authors: Hyun Min Jung, Brittany L Phillips and Edward KL Chan
    Citation: Molecular Cancer 2014 13:80
    Content type: Research Published on:

  41. Acute myeloid leukaemia (AML) is characterised by the halt in maturation of myeloid progenitor cells, combined with uncontrolled proliferation and abnormal survival, leading to the accumulation of immature bla...

    Authors: Catalina A Palma, Dima Al Sheikha, Teck Khai Lim, Adam Bryant, Thi Thanh Vu, Vivek Jayaswal and David D F Ma
    Citation: Molecular Cancer 2014 13:79
    Content type: Research Published on:

  43. M3 and M1 subtype muscarinic receptors are co-expressed in normal and neoplastic intestinal epithelial cells. In mice, ablating Chrm3, the gene encoding M3R, robustly attenuates intestinal tumor formation. Here w...

    Authors: Kunrong Cheng, Guofeng Xie, Sandeep Khurana, Jonathon Heath, Cinthia B Drachenberg, Jennifer Timmons, Nirish Shah and Jean-Pierre Raufman
    Citation: Molecular Cancer 2014 13:77
    Content type: Research Published on:

  44. Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and t...

    Authors: Su Dong, Jing Zhao, Jianxin Wei, Rachel K Bowser, Andrew Khoo, Zhonghui Liu, James D Luketich, Arjun Pennathur, Haichun Ma and Yutong Zhao
    Citation: Molecular Cancer 2014 13:76
    Content type: Research Published on:

  45. Porphyrin TMPyP4 (P4) and its C14H28-alkyl derivative (C14) are G-quadruplex binders and singlet oxygen (1O2) generators. In contrast, TMPyP2 (P2) produces 1O2 but it is not a G-quadruplex binder. As their photos...

    Authors: Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Emilia Della Pietra, Susanna Cogoi and Luigi E Xodo
    Citation: Molecular Cancer 2014 13:75
    Content type: Research Published on:

  46. PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in pr...

    Authors: Lide Alaña, Marta Sesé, Verónica Cánovas, Yolanda Punyal, Yolanda Fernández, Ibane Abasolo, Inés de Torres, Cristina Ruiz, Lluís Espinosa, Anna Bigas, Santiago Ramón y Cajal, Pedro L Fernández, Florenci Serras, Montserrat Corominas, Timothy M Thomson and Rosanna Paciucci
    Citation: Molecular Cancer 2014 13:74
    Content type: Research Published on:

  47. More than 50% of cancer patients are recommended to receive radiotherapy. Recommendations are based mainly on clinical and pathological factors and not intrinsic tumour radio-sensitivity. Use of radiotherapy a...

    Authors: Fiona E Langlands, David Dodwell, Andrew M Hanby, Kieran Horgan, Rebecca A Millican-Slater, Valerie Speirs, Eldo T Verghese, Laura Smith and Thomas A Hughes
    Citation: Molecular Cancer 2014 13:73
    Content type: Research Published on:

  48. Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with signifi...

    Authors: Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Ilango Balakrishnan, Brian Cristiano, Andrew M Donson, Adrian M Dubuc, Michael D Taylor, Nicholas K Foreman, Philip Reigan and Rajeev Vibhakar
    Citation: Molecular Cancer 2014 13:72
    Content type: Research Published on:

  49. While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of...

    Authors: Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown and Lorraine O’Driscoll
    Citation: Molecular Cancer 2014 13:71
    Content type: Research Published on:

  50. Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment (TR) is known to induce autophagy. H...

    Authors: Kamini Singh, Arishya Sharma, Maria C Mir, Judith A Drazba, Warren D Heston, Cristina Magi-Galluzzi, Donna Hansel, Brian P Rubin, Eric A Klein and Alexandru Almasan
    Citation: Molecular Cancer 2014 13:70
    Content type: Research Published on:
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Molecular Cancer

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